Data/hora: 22/06/2024 01:15:18

Biblioteca(s): 	Embrapa Agrossilvipastoril.	
Tipo da produção científica: 	Artigo em Periódico Indexado	
Circulação/Nível: 	A - 3	
Data corrente: 	27/02/2024	
Data da última atualização: 	27/02/2024	
Autoria: 	APOLINÁRIO, L. F.; SILVA, A. T.; ROSA, A. P.; OLIVEIRA, C. da S.; LIRA, C.; GUERRA, J. P. C. dos S.; FRIEDRICH, J. F.; ROSA, L. Q.; CHELEGAO, R.; BOTELHO, S. de C. C.; SINHORIN, V. D. G.; OLIVEIRA, J. C. de; VELLOSO, N. A.	
Afiliação: 	LILIAN FIORAVANSO APOLINÁRIO, UNIVERSIDADE FEDERAL DE MATO GROSSO; AMANDA TAIS SILVA, UNIVERSIDADE FEDERAL DE MATO GROSSO; ANDRIELLI POMPERMAYER ROSA, UNIVERSIDADE FEDERAL DE MATO GROSSO; CLEBER DA SILVA OLIVEIRA, UNIVERSIDADE FEDERAL DE MATO GROSSO; CLEBERSON LIRA, UNIVERSIDADE FEDERAL DE MATO GROSSO; JOÃO PEDRO COSTA DOS SANTOS GUERRA, UNIVERSIDADE FEDERAL DE MATO GROSSO; JÚLIA FURTADO FRIEDRICH, UNIVERSIDADE FEDERAL DE MATO GROSSO; LETÍCIA QUEIROZ ROSA, UNIVERSIDADE FEDERAL DE MATO GROSSO; RODRIGO CHELEGAO, CPAMT; SILVIA DE CARVALHO CAMPOS BOTELHO, CPAMT; VALÉRIA DORNELLES GINDRI SINHORIN, UNIVERSIDADE FEDERAL DE MATO GROSSO; JÚLIO CEZAR DE OLIVEIRA, UNIVERSIDADE FEDERAL DE MATO GROSSO; NÁDIA ALÉSSIO VELLOSO, UNIVERSIDADE FEDERAL DE MATO GROSSO.	
Título: 	Supplementation of the maternal diet with Brazil nut (Bertholletia excelsa H.B.K.) prevents cognitive impairment in the offspring of obese mothers.	
Ano de publicação: 	2024	
Fonte/Imprenta: 	Journal of Developmental Origins of Health and Disease, 2024.	
ISSN: 	2040-1744	
DOI: 	https://doi.org/10.1017/S2040174424000023	
Idioma: 	Inglês	
Notas: 	online first	
Conteúdo: 	Abstract: Maternal obesity may trigger long-term neurodevelopmental disorders in offspring. Considering the benefits of the Brazil nut (Bertholletia excelsa H.B.K.), a rich source of nutrients such as selenium, this study aimed to evaluate its effect on the behavior of obese rat offspring and its relationship with oxidative stress. From 60 days of age until weaning, female Wistar rats were fed a high-fat diet (mHF) or an HF diet supplemented with 5% Brazil nut (mHF/BN), while control mothers (mCTL) were fed a standard diet or a standard diet supplemented with 5% Brazil nut (mBN). Male pups received a standard diet throughout life and, at 30 and 90 days old, were subjected to behavioral tasks to evaluate anxiety and cognition. Biochemical evaluations were performed at 90 days of age. No alterations were observed in the anxiety behavior of the offspring. However, the offspring of the mHF group (oHF) exhibited impaired short-term memory at 30 and 90 days of age and impaired long-term memory at 30 days. Short-term memory impairment was prevented by Brazil nuts in young rats (30 days). While the serum selenium concentration was reduced in the oHF group, the serum catalase concentration was reduced in all groups, without changes in lipid peroxidation or protein carbonylation. Brazil nut maternal diet supplementation prevented short- and long-term cognitive impairment in the offspring, which may be related to the selenium levels.	
Thesagro: 	Bertholletia Excelsa; Castanha; Castanha do Para.	
Thesaurus Nal: 	Brazil nuts; Memory; Neurodevelopment; Obesity; Oxidative stress.	
Categoria do assunto: 	Q Alimentos e Nutrição Humana	
Registro original: 	Embrapa Agrossilvipastoril (CPAMT)	
Exemplares: 	CPAMT - (2033-1) - UPC - AP - DD -  -  -  - DIS