Data/hora: 23/09/2024 18:35:38

Biblioteca(s): 	Embrapa Soja.	
Data corrente: 	15/02/2012	
Data da última atualização: 	05/08/2017	
Autoria: 	CARRARA, V. da S.; AMADO, C. B.; MELO, J. O. de; MANDARINO, J. M. G.; CORTEZ, D. A. G.	
Afiliação: 	VANESSA DA SILVA CARRARA, UEM; CIOMAR BERSANI AMADO, UEM; JULIANA OLIVEIRA DE MELO, UEM; JOSE MARCOS GONTIJO MANDARINO, CNPSO; DIÓGENES APARÍCIO GARCIA CORTEZ, UEM.	
Título: 	Evaluation of soybean methanol fraction on acute inflammation.	
Ano de publicação: 	2011	
Fonte/Imprenta: 	Journal of Medicinal Food, v. 14, n. 12, p. 1570-1575, 2011.	
DOI: 	10.1089/jmf.2010.0320	
Idioma: 	Inglês	
Conteúdo: 	Soybeans have been of interest of researchers because of the presence of isoflavones, a subclass of flavonoids, which have demonstrated anti-inflammatory activity. The aim of this study was investigate the anti-inflammatory activity of the methanol fraction from soybean, which contains mainly isoflavone glucosides and malonylglucosides. The anti-inflammatory activity of the methanol fraction from soybean was studied using croton oil?induced mouse ear edema and carrageenan-induced pleurisy models. The methanol fraction inhibited the ear edema in a dose-dependent manner: 0.625 mg/kg by 44.23% (P < .05), 1.25 mg/kg by 60.68% (P < .01), and 2.5 mg/kg by 65.68% (P < .01). Myeloperoxidase enzyme activity was reduced at the dose of 2.5 mg/kg (64.79%, P < .05). No effects were seen on carrageenan-induced pleurisy at different doses of the methanol fraction (100 or 400 mg/kg). These results demonstrated that the methanol fraction containing conjugated isoflavones showed topical anti-inflammatory activity. There was no acute toxicity in Swiss mice after oral administration of the fraction, at doses of 1,000, 2,000, 3,000, and 4,000 mg/kg.	
Thesagro: 	Antiinflamatório; Soja.	
Thesaurus Nal: 	Acute toxicity; Anti-inflammatory activity; Isoflavones; Soybeans.	
Categoria do assunto: 	F Plantas e Produtos de Origem Vegetal	
Registro original: 	Embrapa Soja (CNPSO)	
Exemplares: 	CNPSO - (32752-1) - UPC - AP - PP - 12055 -  - 12055 - DIS