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| Registros recuperados : 73 | |
| 61. |  | SANTOS, C. M. dos; NEVES, M. R. M. das; BRITO, R. L. L. de; SOUSA, R. T. de; SOUSA, M. M. de; NASCIMENTO, M. T. dos S. C. do; CAVALCANTE, A. C. R.; VIEIRA, L. da S. Efeito do tipo de parto sobre o perfil parasitológico de ovelhas da raça Morada Nova no período de lactação. In: CONGRESSO NORDESTINO DE PRODUÇÃO ANIMAL, 7.; SIMPÓSIO NORDESTINO DE ALIMENTAÇÃO DE RUMINANTES, 13., 2012, Maceió. Anais... Maceió: Sociedade Nordestina de Produção Animal, 2012. 3 f. 1 CD-ROM.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 62. | | SIDER, L. H.; VERAS, A. K. A.; OLIVEIRA, A. N. de; BRITO, R. L. L. de; ANDRIOLI, A.; RAVAZZOLO, A. P.; TEIXEIRA, M. F. da S.; PINHEIRO, R. R. Detecção de RNA genômico do vírus da artrite-encefalite caprina (CAEV) por amplificação do gene estrutural gag em amostras sangüíneas e de líquido sinovial após injúria tecidual. In: SIMPÓSIO INTERNACIONAL SOBRE CAPRINOS E OVINOS DE CORTE, 4.; FEIRA NACIONAL DO AGRONEGÓCIO DA CAPRINO-OVINOCULTURA DE CORTE, 3., 2009, João Pessoa. Anais... João Pessoa: EMEPA-PB, 2009. 3 f. 1 CD-ROM.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 63. | | OLIVEIRA, L. S.; PEREIRA, L. G. R.; AZEVEDO, J. A. G.; PEDREIRA, M. dos S.; LOURES, D. R. S.; BOMFIM, M. A. D.; BARREIROS, D. C.; BRITO, R. L. L. de. Caracterização nutricional de silagens do coproduto da pupunha. Revista Brasileira de Saúde e Produção Animal, v. 11, n. 2, p. 426-439, abr./jun. 2010.| Biblioteca(s): Embrapa Caprinos e Ovinos; Embrapa Gado de Leite. |
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| 64. | | BRITO, R. L. L. de; INÁCIO, S. V.; OLIVEIRA, D. A. dos S.; NAKAMURA, A. A.; SOUSA, M. M. de; NEVES, M. R. M. das; SANTOS, C. M. dos; MEIRELES, M. V.; VIEIRA, L. da S.; BRESCIANI, K. D. S. Caracterização molecular de Cryptosporidium spp. em caprinos jovens de propriedades rurais de Quixadá, Ceará. In: CONGRESSO BRASILEIRO DE PARASITOLOGIA VETERINÁRIA, 18., 2014, Gramado. Fronteiras da parasitologia: anais. Gramado: Colégio Brasileiro de Parasitologia Veterinária, 2014.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 65. | | SANTOS, S. F. dos; CÂNDIDO, M. J. D.; PINHEIRO, R. R.; BRITO, R. L. L. de; OLIVEIRA, L. S.; FONTELES, N. L. de; PEREIRA, L. P. da S.; GOME, G. M. F.; BOMFIM, M. A. D. Effect of the castor bean hulls in dairy goat diets on hematologic profile and hepatic and renal functions. In: INTERNATIONAL CONFERENCE ON GOATS, 10., 2010, Recife. Technological development and associative attempts to a sustainable small livestock production: annals. Little Rock: IGA, 2010. 1 CD-ROM.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 66. | | SIDER, L. H.; VERAS, A. K. A.; OLIVEIRA, A. N. de; BRITO, R. L. L. de; ANDRIOLI, A.; PINHEIRO, R. R.; RAVAZZOLO, A. P.; TEIXEIRA, M. F. da S. Diagnóstico do vírus da artrite-encefalite caprina por RT-Nested PCD. In: SIMPÓSIO EMBRAPA LABEX DE SANIDADE ANIMAL, 1., 2009, Campo Grande, MS. [Resumos...]. Campo Grande, MS: Embrapa Gado de Corte, 2009. 1 CD-ROM.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 67. | | CHAPAVAL, L.; AGUIAR, V. M. P.; VIANA, G. A.; SOUZA, A. P. B. de; MORORÓ, A. M.; MIRANDA, K. P. de; MAGALHÃES, D. C. T.; PINHEIRO, R. R.; BRITO, R. L. L. de. Controle dos casos de mastite e da Artrite Encefalite Caprina com a utilização de boas práticas agropecuárias: uso de procedimentos operacionais e instruções de trabalho no setor leiteiro da Embrapa Caprinos e Ovinos. Sobral: Embrapa Caprinos e Ovinos, 2009. 20 p. (Embrapa Caprinos e Ovinos. Documentos, 86).| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 68. | | ÁVILA, A. A.; ABREU, D. A. de; BRITO, I. F. de; SOUZA, K. C. de; SANTOS, V. W. S. dos; BRITO, R. L. L. de; ANDRIOLI, A.; PINHEIRO, R. R. Influência da artrite encefalite caprina sobre o escore corporal e peso de reprodutores caprinos. In: ENCONTRO DE INICIAÇÃO CIENTÍFICA DA UNIVERSIDADE ESTADUAL VALE DO ACARAÚ, 7., 2010, Sobral. Iniciação para o semiárido: [Resumos]. Sobral: Universidade Estadual Vale do Acaraú, 2010. 1 CD ROM.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 69. | | ELOY, A. M. X.; AGUIAR, F. C. de; PINHEIRO, R. R.; SILVA, N. M. M.; BRITO, R. L. L. de; ARAUJO, A. M. de; BRITO, I. F. de; FURTADO, J. R. Influência dos períodos, seco e chuvoso, sobre os parâmetros clínicos em caprinos das raças Canindé e Moxotó. Revista Brasileira de Medicina Veterinária, v. 33, n. 4, p. 246-252, out./dez. 2011.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 70. | | SOUZA, T. S. de; PINHEIRO, R. R.; LIMA, C. C. V. de; BRITO, R. L. L. de; AZEVEDO, D. A. A. de; DIAS, R. P.; SANTOS, V. W. S. dos; ANDRIOLI, A.; COSTA, J. N. Sheep infection by caprine lentivirus. Revista Brasileira de Saúde e Produção Animal, v. 19, n. 3, p. 268-276, jul./set. 2018.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 71. | | ANDRIOLI, A.; ABREU, D. A. de; PINHEIRO, R. R.; SIDER, L. H.; RODRIGUES, A. de S.; BRITO, R. L. L. de; SOUZA, K. C. de; SANTOS, V. W. S. dos. Técnica de Western Blot para detecção de anticorpos antivírus da Artrite Encefalite Caprina no plasma seminal. Sobral: Embrapa Caprinos e Ovinos, 2012. (Embrapa Caprinos e Ovinos. Comunicado Técnico, 130). Metodologia científica.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 72. | | SOUZA, K. C. de; PINHEIRO, R. R.; SANTOS, D. O.; BRITO, R. L. L. de; RODRIGUES, A. de S.; SIDER, L. H.; PAULA, N. R. O.; AVILAB, A. A.; CARDOSO, J. de F. S.; ANDRIOLI, A. Transmission of the caprine arthritis-encephalitis virus through artificial insemination. Small Ruminant Research, v. 109, n. 2/3, p. 193-198, Jan. 2013.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 73. | | SANTOS, C. M. dos; BRITO, R. L. L. de; SOUSA, R. T. de; SOUSA, M. M. de; FERNANDES, F. E. P.; CAVALCANTE, A. C. R.; VIEIRA, L. da S. Valores de volume globular e proteína plasmática total em cordeiros no período de amamentação. In: CONGRESSO NORDESTINO DE PRODUÇÃO ANIMAL, 7.; SIMPÓSIO NORDESTINO DE ALIMENTAÇÃO DE RUMINANTES, 13., 2012, Maceió. Anais... Maceió: Sociedade Nordestina de Produção Animal, 2012. 3 f. 1 CD-ROM.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| Registros recuperados : 73 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Alimentos e Territórios. Para informações adicionais entre em contato com mara.petrocchi@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Alimentos e Territórios. |
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Data corrente: |
17/11/2023 |
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Data da última atualização: |
17/11/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
SANTOS, F. A.; VIANA, A. F. S. C.; NUNES, P. I. G.; PORTELA, B. Y. M.; ALVES, A. P. N. N.; VIANA, D. DE A.; CARVALHO, K. R.; PEREIRA, R. de C. A.; RIBEIRO, P. R. V.; ALVES FILHO, E. G.; BRITO, E. S. de; SILVEIRA, E. R.; CANUTO, K. M. |
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Afiliação: |
FLÁVIA ALMEIDA SANTOS, Federal University of Ceará; ANA FLÁVIA SERAINE CUSTÓDIO VIANA, Federal University of Ceará; PAULO IURY GOMES NUNES, Federal University of Ceará; BENEDITO YAGO MACHADO PORTELA, Federal University of Ceará; ANA PAULA NEGREIROS NUNES ALVES, Federal University of Ceará; DANIEL DE ARAÚJO VIANA, Christhus University Center; KALINE RODRIGUES CARVALHO, Federal University of Ceara; RITA DE CASSIA ALVES PEREIRA, CNPAT; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; ELENILSON GODOY ALVES-FILHO; EDY SOUSA DE BRITO, CNAT; EDILBERTO ROCHA SILVEIRA, Federal University of Ceará; KIRLEY MARQUES CANUTO, CNPAT. |
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Título: |
UPLC-QTOF-MS/MS-based metabolomic approach and gastroprotective effect of two chemotypes of Egletes viscosa (L.) less. against ethanol-induced gastric ulcer in mice. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Journal of Ethnopharmacology, 116348, june 2023. |
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DOI: |
https://doi.org/10.1016/j.jep.2023.116348 |
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Idioma: |
Inglês |
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Conteúdo: |
Ethnopharmacological relevance: Egletes viscosa (L.) (macela) is a native wild herb that can be found in different states of northeastern Brazil. The infusions of its flower buds are traditionally used for the treatment of gastrointestinal disorders. E. viscosa possesses two chemotypes (named A and B), distinguishable by the composition of the essential oil from the flower buds. Although there are previous studies of the gastroprotective effect of the isolated constituents of E. viscosa, its infusions have not been investigated yet. Aim of the study: The present study aimed to evaluate and compare the chemical composition and the gastroprotective effect of flower bud infusions of E. viscosa from chemotype A (EVCA) and chemotype B (EVCB). Materials and methods: Sixteen infusions were brewed with flower buds according to the traditional preparation mode and were analyzed through a UPLC-QTOF-MS/MS based metabolomic approach for determination of their metabolic fingerprints and quantification of bioactive compounds. Afterward, these data were analyzed by chemometric methods (OPLS-DA) for discrimination of the two chemotypes. Additionally, infusions of EVCA and EVCB (50, 100 and 200 mg/kg, p.o.) were evaluated on gastric ulcers induced by absolute ethanol (96%, 0.2 mL, p.o.) in mice. To elucidate the gastroprotective mechanisms, the effect of EVCA and EVCB on gastric acid secretion and gastric wall mucus was determined and the role of TRPV1 channels, prostaglandins, nitric oxide and KATP channels were assessed. Moreover, the oxidative stress-related parameters and the histological aspects of the stomach tissue were analyzed. Results: The chemotypes can be discriminated from each other using UPLC-QTOF-MS/MS chemical fingerprints. Both chemotypes presented similar chemical compositions, consisting basically of caffeic acid derivatives, flavonoids and diterpenes. The quantification of bioactive compounds demonstrated that chemotype A possesses more ternatin, tanabalin and centipedic than chemotype B. EVCA and EVCB (50, 100 and 200 mg/kg, p.o.) significantly decreased the severity of ethanol-induced gastric lesions, as shown by a reduction in histological alterations and leucocyte infiltration in gastric tissue. The gastroprotective mechanism of both infusions involves an antioxidant effect, maintenance of gastric mucus and reduction gastric secretion. Stimulation of endogenous prostaglandins and nitric oxide release, activation of TRPV1 channels, and KATP channels are also involved in the gastroprotection of the infusions. Conclusion: The gastroprotective effect of EVCA and EVCB was equivalent and mediated through antioxidant and antisecretory actions, including the activation of TRPV1 receptors, stimulation of endogenous prostaglandins and nitric oxide, and opening of KATP channels. The presence of caffeic acid derivatives, flavonoids and diterpenes in both infusions is involved in mediating this protective effect. Our findings support the traditional use of infusions of E. viscosa for gastric disorders regardless of the chemotype. MenosEthnopharmacological relevance: Egletes viscosa (L.) (macela) is a native wild herb that can be found in different states of northeastern Brazil. The infusions of its flower buds are traditionally used for the treatment of gastrointestinal disorders. E. viscosa possesses two chemotypes (named A and B), distinguishable by the composition of the essential oil from the flower buds. Although there are previous studies of the gastroprotective effect of the isolated constituents of E. viscosa, its infusions have not been investigated yet. Aim of the study: The present study aimed to evaluate and compare the chemical composition and the gastroprotective effect of flower bud infusions of E. viscosa from chemotype A (EVCA) and chemotype B (EVCB). Materials and methods: Sixteen infusions were brewed with flower buds according to the traditional preparation mode and were analyzed through a UPLC-QTOF-MS/MS based metabolomic approach for determination of their metabolic fingerprints and quantification of bioactive compounds. Afterward, these data were analyzed by chemometric methods (OPLS-DA) for discrimination of the two chemotypes. Additionally, infusions of EVCA and EVCB (50, 100 and 200 mg/kg, p.o.) were evaluated on gastric ulcers induced by absolute ethanol (96%, 0.2 mL, p.o.) in mice. To elucidate the gastroprotective mechanisms, the effect of EVCA and EVCB on gastric acid secretion and gastric wall mucus was determined and the role of TRPV1 channels, prostaglandins, nitric oxide ... Mostrar Tudo |
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Palavras-Chave: |
Diterpenes; Egletes viscosa; Gastric ulcer. |
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Thesaurus NAL: |
Flavonoids; Phenolic acids. |
|
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
|
Marc: |
LEADER 04150naa a2200337 a 4500
001 2158523
005 2023-11-17
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.jep.2023.116348$2DOI
100 1 $aSANTOS, F. A.
245 $aUPLC-QTOF-MS/MS-based metabolomic approach and gastroprotective effect of two chemotypes of Egletes viscosa (L.) less. against ethanol-induced gastric ulcer in mice.$h[electronic resource]
260 $c2023
520 $aEthnopharmacological relevance: Egletes viscosa (L.) (macela) is a native wild herb that can be found in different states of northeastern Brazil. The infusions of its flower buds are traditionally used for the treatment of gastrointestinal disorders. E. viscosa possesses two chemotypes (named A and B), distinguishable by the composition of the essential oil from the flower buds. Although there are previous studies of the gastroprotective effect of the isolated constituents of E. viscosa, its infusions have not been investigated yet. Aim of the study: The present study aimed to evaluate and compare the chemical composition and the gastroprotective effect of flower bud infusions of E. viscosa from chemotype A (EVCA) and chemotype B (EVCB). Materials and methods: Sixteen infusions were brewed with flower buds according to the traditional preparation mode and were analyzed through a UPLC-QTOF-MS/MS based metabolomic approach for determination of their metabolic fingerprints and quantification of bioactive compounds. Afterward, these data were analyzed by chemometric methods (OPLS-DA) for discrimination of the two chemotypes. Additionally, infusions of EVCA and EVCB (50, 100 and 200 mg/kg, p.o.) were evaluated on gastric ulcers induced by absolute ethanol (96%, 0.2 mL, p.o.) in mice. To elucidate the gastroprotective mechanisms, the effect of EVCA and EVCB on gastric acid secretion and gastric wall mucus was determined and the role of TRPV1 channels, prostaglandins, nitric oxide and KATP channels were assessed. Moreover, the oxidative stress-related parameters and the histological aspects of the stomach tissue were analyzed. Results: The chemotypes can be discriminated from each other using UPLC-QTOF-MS/MS chemical fingerprints. Both chemotypes presented similar chemical compositions, consisting basically of caffeic acid derivatives, flavonoids and diterpenes. The quantification of bioactive compounds demonstrated that chemotype A possesses more ternatin, tanabalin and centipedic than chemotype B. EVCA and EVCB (50, 100 and 200 mg/kg, p.o.) significantly decreased the severity of ethanol-induced gastric lesions, as shown by a reduction in histological alterations and leucocyte infiltration in gastric tissue. The gastroprotective mechanism of both infusions involves an antioxidant effect, maintenance of gastric mucus and reduction gastric secretion. Stimulation of endogenous prostaglandins and nitric oxide release, activation of TRPV1 channels, and KATP channels are also involved in the gastroprotection of the infusions. Conclusion: The gastroprotective effect of EVCA and EVCB was equivalent and mediated through antioxidant and antisecretory actions, including the activation of TRPV1 receptors, stimulation of endogenous prostaglandins and nitric oxide, and opening of KATP channels. The presence of caffeic acid derivatives, flavonoids and diterpenes in both infusions is involved in mediating this protective effect. Our findings support the traditional use of infusions of E. viscosa for gastric disorders regardless of the chemotype.
650 $aFlavonoids
650 $aPhenolic acids
653 $aDiterpenes
653 $aEgletes viscosa
653 $aGastric ulcer
700 1 $aVIANA, A. F. S. C.
700 1 $aNUNES, P. I. G.
700 1 $aPORTELA, B. Y. M.
700 1 $aALVES, A. P. N. N.
700 1 $aVIANA, D. DE A.
700 1 $aCARVALHO, K. R.
700 1 $aPEREIRA, R. de C. A.
700 1 $aRIBEIRO, P. R. V.
700 1 $aALVES FILHO, E. G.
700 1 $aBRITO, E. S. de
700 1 $aSILVEIRA, E. R.
700 1 $aCANUTO, K. M.
773 $tJournal of Ethnopharmacology, 116348, june 2023.
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