Data/hora: 03/06/2024 08:11:05

Biblioteca(s): | Embrapa Caprinos e Ovinos.
Tipo da produção científica: | Artigo em Periódico Indexado
Circulação/Nível: | A - 1
Data corrente: | 04/10/2011
Data da última atualização: | 23/09/2019
Autoria: | BRINGHENTI, I.; SCHULTZA, A.; RACHIDA, T.; BOMFIM, M. A. D.; MANDARIM-DE-LACERDA, C. A.; AGUILA, M. B.
Afiliação: | Isabele Bringhenti, Laboratory of Morphometry, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, RJ.; Alini Schultza; Tamiris Rachida; MARCO AURELIO DELMONDES BOMFIM, CNPC; Carlos A. Mandarim-de-Lacerda; Marcia B. Aguila.
Título: | An early fish oil-enriched diet reverses biochemical, liver and adipose tissue alterations in male offspring from maternal protein restriction in mice.
Ano de publicação: | 2011
Fonte/Imprenta: | The Journal of Nutritional Biochemistry, v. 22, n. 11, p. 1009-1014, Nov. 2011.
Idioma: | Inglês
Conteúdo: | Fetal programming is linked to adulthood metabolic and chronic diseases. We hypothesized that early fish oil (FO) intake would revert the programming responses in adult offspring. Pregnant mice were fed either standard chow (SC) or a low-protein diet (LP) throughout pregnancy/lactation. At weaning, the following groups were formed: SC and SC-FO, LP and LP-FO, which were fed SC or SC+FO, respectively. The LP offspring are predisposed to becoming fat, hypercholesterolemic and hyperglycemic. In addition, during adulthood, they become hypertensive with hepatic steatosis and have a high level of sterol regulatory element binding protein (SREBP-1). However, LP offspring that were fed an FO-enriched diet have decreased body mass (BM) gain and lower final BM. In addition, with this diet, these mice have improved lipid metabolism with a decrease in total cholesterol (TC) and triacylglyceride (TG) levels, reduced fat pad masses and reduced adipocyte size. Furthermore, these LP offspring show reduced liver structural damage of alanine aminotransferase (ALT), liver steatosis with low SREBP-1 protein expression and high peroxisome proliferator activity receptor-alpha expression, and improvement of blood pressure (BP) and tumor necrosis factor (TNF)-alpha level. Early fish oil intake has beneficial effects on the programming responses that control body fat pad, glucose and lipid metabolism, and liver and adipose tissue structure in adult programmed offspring.
Palavras-Chave: | Fígado gorduroso; Fish oil; Hipertensão; Óleo de peixe; Protein restriction; Resistência a insulina; Restrição proteíca.
Thesagro: | Obesidade.
Thesaurus Nal: | Fatty liver; Hypertension; Insulin resistance; Obesity.
Categoria do assunto: | --
Registro original: | Embrapa Caprinos e Ovinos (CNPC)
Exemplares: | CNPC - (24655-1) - UPC - AP - DD -  -  -  - DIS