Data/hora: 23/06/2024 20:08:08

Biblioteca(s): | Embrapa Agricultura Digital.
Data corrente: | 22/12/2009
Data da última atualização: | 15/01/2020
Autoria: | VIEIRA, F. D.; AGOSTINHO, G. C.; REGITANO, L. C. A.; YAMAGISHI, M. E. B.
Afiliação: | FABIO DANILO VIEIRA, CNPTIA; GILBERTO CESAR AGOSTINHO, CPPSE; LUCIANA CORREIA ALMEIDA REGITANO, CPPSE; MICHEL EDUARDO BELEZA YAMAGISHI, CNPTIA.
Título: | Database modeling and web interface system: on-line genomic association studies.
Ano de publicação: | 2009
Fonte/Imprenta: | In: INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 5., 2009, Angra dos Reis. Abstracts book... Angra dos Reis: ABBCB, 2009.
Páginas: | Não paginado.
Idioma: | Inglês
Notas: | X-Meeting 2009.
Conteúdo: | Animal selection is an important phase of any animal breeding program. However, if the selection is not based on easily observable (or measurable) traits, then selection is much tricker. One alternative is to use Marker Assisted Selection (MAS), where genetic markers are positively associated with the desired traits (Duran et al., 2009). MAS has been powered by the advent of large scale SNP genotyping technologies which produces thousands (even millions) of markers in a single chip. However, this huge number of genetic markers brings new challenges to the international scientfic community such as database modeling and the development of association analysis tools capable of dealing with greatly increased volume of information (LaFramboise, 2009). Although no format files are widely accepted as standard and the major commercial SNP chip companies (Affymatrix, Illumina) release their results through flat files, some important whole genome association analysis freeware softwares adopt .PED and .MAP format files as input. In this work, we present a database model and a Web parser system that reads flat files (Illumina, Affymetrix) and generates corresponding .PED and .MAP format files. Furthermore, through the Web interface it is possible to run PLINK (Purcell et al., 2007) routines such as some statistical and association analysis. Noteworthy that the database model was designed in order to speed up all the tasks and turn possible to run online any of the implemented routines.
Palavras-Chave: | Bioinformática; Marcadores genéticos; Marker Assisted Selection (MAS); Modelagem de dados; Sistema de interface web.
Thesaurus Nal: | Bioinformatics; Genetic markers; Models.
Categoria do assunto: | X Pesquisa, Tecnologia e Engenharia
Registro original: | Embrapa Agricultura Digital (CNPTIA)

Exemplares:

CNPTIA - (14371-1) - UPC - RA - PP -  -  - 2009.00168 - DES
CNPTIA - (14371-2) - UPC - RA - DD -  -  -  - DIS