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Registro Completo |
Biblioteca(s): |
Embrapa Instrumentação. |
Data corrente: |
05/07/2023 |
Data da última atualização: |
15/01/2024 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
TEODORO, K. B. R.; ALVARENGA, A. D.; OLIVEIRA, L. F. R.; CHAGAS, P. A. M.; LOPES. R. G.; ANDRE, R. S.; MERCANTE, L. A.; ALVES, F.; STRINGASCI, M. D.; BUZZA, H. H.; INADA, N. M.; CORREA, D. S. |
Afiliação: |
DANIEL SOUZA CORREA, CNPDIA. |
Título: |
Fast Fabrication of Multifunctional PCL/Curcumin Nanofibrous Membranes for Wound Dressings. |
Ano de publicação: |
2023 |
Fonte/Imprenta: |
ACS Applied Bio Materials, v. 6, 2023. |
Páginas: |
2325–2337 |
DOI: |
https://doi.org/10.1021/acsabm.3c00177 |
Idioma: |
Inglês |
Conteúdo: |
herapeutic intervention to skin wounds requires covering the affected area with wound dressings. Interdisciplinary efforts have focused on the development of smart bandages that can perform multiple functions. In this direction, here, we designed a low cost (U$0.012 per cm2 ) multifunctional therapeutic wound dressing fabricated by loading curcumin (CC) into poly(ϵ-caprolactone) (PCL) nanofibers using solution blow spinning (SBS). The freestanding PCL/CC bandages were characterized by distinct physicochemical approaches and were successful in performing varied functions, including controlled release of CC, colorimetric indication of the wound conditions, barrier against microorganisms, being biocompatible, and providing a photosensitive platform for antimicrobial photodynamic therapy (aPDT). The chemical nature of PCL and CC and the interactions between these components allowed CC to be released for 192 h (ca. 8 days), which could be correlated with the Korsmeyer−Peppas model, with a burst release suitable to treat the inflammatory phase. Due to the CC keto−enol tautomerism, an optical indication of the healing status could be obtained using PCL/CC, which occurred immediately, ranging between red/orange and yellow shades. The effect against pathogenic microorganisms evaluated by agar disc-diffusion, affected skin wound simulation (ex vivo), and microbial penetration tests demonstrated the ability to block and inhibit microbial permeation in different environments. The biocompatibilities of PCL and PCL/CC were verified by in vitro cytotoxicity study, which demonstrated that cell viabilities average above 94 and 96% for human dermal fibroblasts. In addition, the proposed bandage responded to aPDT applied to an in vivo assay, showing that, when irritated, PCL/CC was able to reduce the bacteria present on the real wound of mice. In summary, our findings demonstrate that using PCL and CC to produce nonwovens by the SBS technique offers potential for the rapid fabrication of biocompatible and multifunctional wound dressings, paving the way for large-scale production and utilization of such dressings in the treatment of skin wounds. Menosherapeutic intervention to skin wounds requires covering the affected area with wound dressings. Interdisciplinary efforts have focused on the development of smart bandages that can perform multiple functions. In this direction, here, we designed a low cost (U$0.012 per cm2 ) multifunctional therapeutic wound dressing fabricated by loading curcumin (CC) into poly(ϵ-caprolactone) (PCL) nanofibers using solution blow spinning (SBS). The freestanding PCL/CC bandages were characterized by distinct physicochemical approaches and were successful in performing varied functions, including controlled release of CC, colorimetric indication of the wound conditions, barrier against microorganisms, being biocompatible, and providing a photosensitive platform for antimicrobial photodynamic therapy (aPDT). The chemical nature of PCL and CC and the interactions between these components allowed CC to be released for 192 h (ca. 8 days), which could be correlated with the Korsmeyer−Peppas model, with a burst release suitable to treat the inflammatory phase. Due to the CC keto−enol tautomerism, an optical indication of the healing status could be obtained using PCL/CC, which occurred immediately, ranging between red/orange and yellow shades. The effect against pathogenic microorganisms evaluated by agar disc-diffusion, affected skin wound simulation (ex vivo), and microbial penetration tests demonstrated the ability to block and inhibit microbial permeation in different enviro... Mostrar Tudo |
Palavras-Chave: |
Natural dye; Optical sensor; Photodynamic therapy; Solution blow spinning; Wound dressing. |
Categoria do assunto: |
-- |
Marc: |
LEADER 03154naa a2200337 a 4500 001 2154815 005 2024-01-15 008 2023 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1021/acsabm.3c00177$2DOI 100 1 $aTEODORO, K. B. R. 245 $aFast Fabrication of Multifunctional PCL/Curcumin Nanofibrous Membranes for Wound Dressings.$h[electronic resource] 260 $c2023 300 $a2325–2337 520 $aherapeutic intervention to skin wounds requires covering the affected area with wound dressings. Interdisciplinary efforts have focused on the development of smart bandages that can perform multiple functions. In this direction, here, we designed a low cost (U$0.012 per cm2 ) multifunctional therapeutic wound dressing fabricated by loading curcumin (CC) into poly(ϵ-caprolactone) (PCL) nanofibers using solution blow spinning (SBS). The freestanding PCL/CC bandages were characterized by distinct physicochemical approaches and were successful in performing varied functions, including controlled release of CC, colorimetric indication of the wound conditions, barrier against microorganisms, being biocompatible, and providing a photosensitive platform for antimicrobial photodynamic therapy (aPDT). The chemical nature of PCL and CC and the interactions between these components allowed CC to be released for 192 h (ca. 8 days), which could be correlated with the Korsmeyer−Peppas model, with a burst release suitable to treat the inflammatory phase. Due to the CC keto−enol tautomerism, an optical indication of the healing status could be obtained using PCL/CC, which occurred immediately, ranging between red/orange and yellow shades. The effect against pathogenic microorganisms evaluated by agar disc-diffusion, affected skin wound simulation (ex vivo), and microbial penetration tests demonstrated the ability to block and inhibit microbial permeation in different environments. The biocompatibilities of PCL and PCL/CC were verified by in vitro cytotoxicity study, which demonstrated that cell viabilities average above 94 and 96% for human dermal fibroblasts. In addition, the proposed bandage responded to aPDT applied to an in vivo assay, showing that, when irritated, PCL/CC was able to reduce the bacteria present on the real wound of mice. In summary, our findings demonstrate that using PCL and CC to produce nonwovens by the SBS technique offers potential for the rapid fabrication of biocompatible and multifunctional wound dressings, paving the way for large-scale production and utilization of such dressings in the treatment of skin wounds. 653 $aNatural dye 653 $aOptical sensor 653 $aPhotodynamic therapy 653 $aSolution blow spinning 653 $aWound dressing 700 1 $aALVARENGA, A. D. 700 1 $aOLIVEIRA, L. F. R. 700 1 $aCHAGAS, P. A. M. 700 1 $aLOPES. R. G. 700 1 $aANDRE, R. S. 700 1 $aMERCANTE, L. A. 700 1 $aALVES, F. 700 1 $aSTRINGASCI, M. D. 700 1 $aBUZZA, H. H. 700 1 $aINADA, N. M. 700 1 $aCORREA, D. S. 773 $tACS Applied Bio Materials$gv. 6, 2023.
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Embrapa Instrumentação (CNPDIA) |
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Registro Completo
Biblioteca(s): |
Embrapa Semiárido. |
Data corrente: |
12/02/1996 |
Data da última atualização: |
06/06/2022 |
Tipo da produção científica: |
Folder/Folheto/Cartilha |
Autoria: |
PEDROSA, J. F.; FARIA, C. M. B. de. |
Afiliação: |
CLEMENTINO MARCOS BATISTA DE FARIA, CPATSA. |
Título: |
Cultura do melao. |
Ano de publicação: |
1995 |
Fonte/Imprenta: |
Petrolina: EMBRAPA-CPATSA, 1995. |
Páginas: |
30 p. |
Idioma: |
Português |
Notas: |
Apostila do Curso de Atualizacao Tecnica para Engenheiros Agronomos do Banco do Brasil, Petrolina, 1995. Nao publicado. |
Conteúdo: |
Importancia; Origem e botanica; Exigencia climatica; Cultivares; O solo e seu preparo; Plantio; Tratos culturais; Disturbios fisiologicos; Colheita, Classificacao, embalagem e comercializacao. |
Palavras-Chave: |
Cucurbit; Cultivar; Cultivation; Cultivo; Eldorado 300; Gold mine; Horticultural; Melon; Muskmelon; Production; Valenciano amarelo; Yellow king. |
Thesagro: |
Adubação; Cucumis Melo; Irrigação; Melão; Poda; Produção Vegetal; Solo; Taxonomia. |
Thesaurus NAL: |
botany. |
Categoria do assunto: |
-- F Plantas e Produtos de Origem Vegetal |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/137270/1/ID-7747.pdf
|
Marc: |
LEADER 01195nam a2200397 a 4500 001 1132786 005 2022-06-06 008 1995 bl uuuu u0uu1 u #d 100 1 $aPEDROSA, J. F. 245 $aCultura do melao. 260 $aPetrolina: EMBRAPA-CPATSA$c1995 300 $a30 p. 500 $aApostila do Curso de Atualizacao Tecnica para Engenheiros Agronomos do Banco do Brasil, Petrolina, 1995. Nao publicado. 520 $aImportancia; Origem e botanica; Exigencia climatica; Cultivares; O solo e seu preparo; Plantio; Tratos culturais; Disturbios fisiologicos; Colheita, Classificacao, embalagem e comercializacao. 650 $abotany 650 $aAdubação 650 $aCucumis Melo 650 $aIrrigação 650 $aMelão 650 $aPoda 650 $aProdução Vegetal 650 $aSolo 650 $aTaxonomia 653 $aCucurbit 653 $aCultivar 653 $aCultivation 653 $aCultivo 653 $aEldorado 300 653 $aGold mine 653 $aHorticultural 653 $aMelon 653 $aMuskmelon 653 $aProduction 653 $aValenciano amarelo 653 $aYellow king 700 1 $aFARIA, C. M. B. de
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