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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
25/03/2024 |
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Data da última atualização: |
26/06/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CARVALHO, W. A.; GASPAR, E. B.; DOMINGUES, R.; REGITANO, L. C. de A.; CARDOSO, F. F. |
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Afiliação: |
WANESSA ARAUJO CARVALHO, CNPGL; EMANUELLE BALDO GASPAR, CNPGL; ROBERT DOMINGUES, CNPGL; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; FERNANDO FLORES CARDOSO, CPPSUL. |
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Título: |
Genetic factors underlying host resistance to Rhipicephalus microplus tick infestation in Braford cattle: a systems biology perspective. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Mammalian Genome, v. 35, p. 186-200, 2024. |
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DOI: |
https://doi.org/10.1007/s00335-024-10030-x |
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Idioma: |
Inglês |
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Conteúdo: |
Approximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates to improve the accuracy of genomic predictions for tick resistance in Braford cattle. MenosApproximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates ... Mostrar Tudo |
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Thesagro: |
Bovino; Carrapato; Doença Animal; Parasitismo; Resistência. |
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Thesaurus Nal: |
Amber disease; Parasitism; Ticks. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02420naa a2200277 a 4500
001 2163111
005 2024-06-26
008 2024 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s00335-024-10030-x$2DOI
100 1 $aCARVALHO, W. A.
245 $aGenetic factors underlying host resistance to Rhipicephalus microplus tick infestation in Braford cattle$ba systems biology perspective.$h[electronic resource]
260 $c2024
520 $aApproximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates to improve the accuracy of genomic predictions for tick resistance in Braford cattle.
650 $aAmber disease
650 $aParasitism
650 $aTicks
650 $aBovino
650 $aCarrapato
650 $aDoença Animal
650 $aParasitismo
650 $aResistência
700 1 $aGASPAR, E. B.
700 1 $aDOMINGUES, R.
700 1 $aREGITANO, L. C. de A.
700 1 $aCARDOSO, F. F.
773 $tMammalian Genome$gv. 35, p. 186-200, 2024.
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| 4. |  | MORAIS, S. L. de; SILVEIRA, M. C. T. da. Características morfogênicas correlacionadas com a produção de forragem de Paspalum regnellii submetido a diferentes alturas. In: JORNADA DE PÓS-GRADUAÇÃO E PESQUISA, 11.; MOSTRA DE INICIAÇÃO CIENTÍFICA, 11.; MOSTRA DE INICIAÇÃO CIENTÍFICA JÚNIOR, 9., 2013, Sant'Ana do Livramento. Anais... Bagé: Ediurcamp, 2013. 1 pen drive. CONGREGA. João Carlos Pinto Oliveira, Gabriel Streck Bortolin, Maurício Marini Kopp, Marcos Jun Iti Yokoo, Juliano Lino Ferreira.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 14. | | ULRICH, A. M.; MALCORRA, M. P.; FAGUNDES, B. F.; SILVEIRA, M. C. T. da; TRENTIN, G. Eficiência do uso da água na cultura do azevém (Lolium multiflorum). In: CONGRESSO DE INICIAÇÃO CIENTÍFICA, 27.; SEMANA INTEGRADA DE ENSINO, PESQUISA E EXTENSÃO, 4., 2018, Pelotas. Anais eletrônicos... Pelotas: UFPel, 2018. CIC.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 15. | | MALCORRA, M. P.; FAGUNDES, B. F.; ULRICH, A. M.; SILVEIRA, M. C. T. da; TRENTIN, G. Eficiência do uso da água na cultura do capim sudão (Sorghum sudanense) entre os cortes. In: CONGRESSO DE INICIAÇÃO CIENTÍFICA, 27.; SEMANA INTEGRADA DE ENSINO, PESQUISA E EXTENSÃO, 4., 2018, Pelotas. Anais eletrônicos... Pelotas: UFPel, 2018. CIC.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 16. | | LEMOS, J. M.; MORAIS, S. L.; SILVEIRA, M. C. T. da; KOPP, M. M.; TRENTIN, G. Eficiência no uso da água do Paspalum rignelli. In: JORNADA DE PÓS-GRADUAÇÃO E PESQUISA, 12.; MOSTRA DE INICIAÇÃO CIENTÍFICA, 12.; MOSTRA DE INICIAÇÃO CIENTÍFICA JÚNIOR, 10.; MOSTRA INTERNACIONAL DE FOTOGRAFIA, 2., 2014, Bagé. Anais... Bagé: Ediurcamp, 2014. CONGREGA.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| Registros recuperados : 154 | |
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