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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
24/11/2004 |
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Data da última atualização: |
02/10/2023 |
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Autoria: |
TACHIBANA, S.; ARAKI, K.; OHYA, S.; YOSHIDA, S. |
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Título: |
Isolation and structure of dynorphin, an opioid peptide, from porcine duodenum. |
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Ano de publicação: |
1982 |
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Fonte/Imprenta: |
Nature, v. 295, p. 339-340, Jan. 1982. |
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DOI: |
doi:10.1038/295339a0 |
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Idioma: |
Inglês |
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Conteúdo: |
The presence of endogenous ligands of opiate receptors in gastrointestinal organs has been demonstrated by both bioassay and immunoassay but so far no ligand has been precisely identified. We report here the purification from porcine duodenum of an opioid peptide whose structure coincides with that of the pituitary opioid, dynorphin1. Only the N-terminal tridecapeptide of pituitary dynorphin has been published; we have now determined the complete sequence of duodenal dynorphin, and measured its content in the duodenum by radioimmunoassay2. We report here that the complete heptadecapeptide has almost the same potency as dynorphin1?13 in two bioassays. |
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Palavras-Chave: |
Bioquimica molecular; Carboxypeptidases A; Dynorphins; Opioide; Peptide Fragments; Radioimmunossay. |
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Thesaurus Nal: |
Amino acid sequences; Endorphins; Swine; Trypsin. |
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Categoria do assunto: |
K Ciência Florestal e Produtos de Origem Vegetal |
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Marc: |
LEADER 01443naa a2200289 a 4500
001 1515662
005 2023-10-02
008 1982 bl uuuu u00u1 u #d
024 7 $adoi:10.1038/295339a0$2DOI
100 1 $aTACHIBANA, S.
245 $aIsolation and structure of dynorphin, an opioid peptide, from porcine duodenum.$h[electronic resource]
260 $c1982
520 $aThe presence of endogenous ligands of opiate receptors in gastrointestinal organs has been demonstrated by both bioassay and immunoassay but so far no ligand has been precisely identified. We report here the purification from porcine duodenum of an opioid peptide whose structure coincides with that of the pituitary opioid, dynorphin1. Only the N-terminal tridecapeptide of pituitary dynorphin has been published; we have now determined the complete sequence of duodenal dynorphin, and measured its content in the duodenum by radioimmunoassay2. We report here that the complete heptadecapeptide has almost the same potency as dynorphin1?13 in two bioassays.
650 $aAmino acid sequences
650 $aEndorphins
650 $aSwine
650 $aTrypsin
653 $aBioquimica molecular
653 $aCarboxypeptidases A
653 $aDynorphins
653 $aOpioide
653 $aPeptide Fragments
653 $aRadioimmunossay
700 1 $aARAKI, K.
700 1 $aOHYA, S.
700 1 $aYOSHIDA, S.
773 $tNature$gv. 295, p. 339-340, Jan. 1982.
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Embrapa Caprinos e Ovinos (CNPC) |
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| 1. |  | SOUSA, T. P de; MARQUES, D. K. S.; VITORINO, C de A.; FARIA, K. de C.; BRAGA, G. da S. F.; FERREIRA, D. C.; VENERE, P. C. Cytogenetic and molecular data support the occurrence of three Gymnotus Species (Gymnotiformes: Gymnotidae) used as live bait in Corumbá, Brazil: implications for conservation and management of professional fishing. Zebrafish, v. 14, n. 2, p. 177-186, 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
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