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Registro Completo |
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Biblioteca(s): |
Embrapa Pantanal. |
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Data corrente: |
04/08/1995 |
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Data da última atualização: |
04/08/1995 |
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Autoria: |
GREGG, P.; DINEEN, J. K.; ROTHWELL, T. L. W.; KELLY, J. D. |
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Título: |
The effect of age on the response of sheep to vaccination with irradiated Trichostrongylus colubriformis larvae. |
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Ano de publicação: |
1978 |
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Fonte/Imprenta: |
Veterinary Parasitology, v.4, p.35-48, 1978. |
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Idioma: |
Inglês |
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Conteúdo: |
Vaccination with irradiated Trichostrongylus colubriformis larvae produced a high level of immunity, as judged by faecal egg counts and worm burdens following challenge with normal larvae, in nine of ten sheep aged 10 months. In lambs aged 3 months, vaccination
was less effective. Some lambs developed partial immunity, but others did not respond. Serum levels of antibodies to T. colubriformis acetylcholinesterase reflected the extent of antigenic exposure rather than the degree of immunity acquired, and there was no evidence that the unresponsiveness of the lambs was due to a deficiency in antibody production. Unresponsiveness was not associated with the numbers of circulating lymphocytes, monocytes or granulocytes, or with the numbers of mast cells, eosinophils
and neutrophils at the site of infection. However, there were many globule leucocytes in the intestinal mucosa of adult sheep which were resistant to challenge infection. On the other hand, few of these cells were found in vaccinated lambs which generally gave a poor response to challenge. |
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Palavras-Chave: |
Parasita; Parasite; Vaccine. |
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Thesagro: |
Carneiro; Imunidade; Larva; Vacina. |
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Thesaurus Nal: |
immunity; larvae; sheep; Trichostrongylus colubriformis. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01820naa a2200289 a 4500
001 1785297
005 1995-08-04
008 1978 bl --- 0-- u #d
100 1 $aGREGG, P.
245 $aThe effect of age on the response of sheep to vaccination with irradiated Trichostrongylus colubriformis larvae.
260 $c1978
520 $aVaccination with irradiated Trichostrongylus colubriformis larvae produced a high level of immunity, as judged by faecal egg counts and worm burdens following challenge with normal larvae, in nine of ten sheep aged 10 months. In lambs aged 3 months, vaccination was less effective. Some lambs developed partial immunity, but others did not respond. Serum levels of antibodies to T. colubriformis acetylcholinesterase reflected the extent of antigenic exposure rather than the degree of immunity acquired, and there was no evidence that the unresponsiveness of the lambs was due to a deficiency in antibody production. Unresponsiveness was not associated with the numbers of circulating lymphocytes, monocytes or granulocytes, or with the numbers of mast cells, eosinophils and neutrophils at the site of infection. However, there were many globule leucocytes in the intestinal mucosa of adult sheep which were resistant to challenge infection. On the other hand, few of these cells were found in vaccinated lambs which generally gave a poor response to challenge.
650 $aimmunity
650 $alarvae
650 $asheep
650 $aTrichostrongylus colubriformis
650 $aCarneiro
650 $aImunidade
650 $aLarva
650 $aVacina
653 $aParasita
653 $aParasite
653 $aVaccine
700 1 $aDINEEN, J. K.
700 1 $aROTHWELL, T. L. W.
700 1 $aKELLY, J. D.
773 $tVeterinary Parasitology$gv.4, p.35-48, 1978.
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Embrapa Pantanal (CPAP) |
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