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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
10/03/2023 |
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Data da última atualização: |
28/11/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GUEDES, M. D. V.; MARQUES, M. S.; BERLITZ, S. J.; FACURE, M. H. M.; CORREA, D. S.; STEFFENS, C.; CONTRI, R. V.; KÜLKAMP-GUERRREIRO, I. C. |
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Afiliação: |
MARINA D. V. GUEDES, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL; MORGANA S. MARQUES, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL; SIMONE J. BERLITZ, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL; MURILO H. M. FACURE, UNIVERSIDADE FEDERAL DE SÃO CARLOS; DANIEL SOUZA CORREA, CNPDIA; CLARICE STEFFENS, UNIVERSIDADE REGIONAL INTEGRADA DO ALTO URUGUAI E MISSÕES; RENATA V. CONTRI, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL; IRENE C. KÜLKAMP-GUERREIRO, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL. |
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Título: |
Lamivudine and Zidovudine-Loaded Nanostructures: Green Chemistry Preparation for Pediatric Oral Administration. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Nanomaterials, v. 13, 770, 2023. |
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Páginas: |
1 - 18 |
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DOI: |
https://doi.org/10.3390/nano13040770 |
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Idioma: |
Inglês |
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Conteúdo: |
Here, we report on the development of lipid-based nanostructures containing zidovudine (1 mg/mL) and lamivudine (0.5 mg/mL) for oral administration in the pediatric population, eliminating the use of organic solvents, which is in accordance with green chemistry principles. The formulations were obtained by ultrasonication using monoolein (MN) or phytantriol (PN), which presented narrow size distributions with similar mean particle sizes (~150 nm) determined by laser diffraction. The zeta potential and the pH values of the formulations were around −4.0 mV and 6.0, respectively. MN presented a slightly higher incorporation rate compared to PN. Nanoemulsions were obtained when using monoolein, while cubosomes were obtained when using phytantriol, as confirmed by Small-Angle X-ray Scattering. The formulations enabled drug release control and protection against acid degradation. The drug incorporation was effective and the analyses using an electronic tongue indicated a difference in palatability between the nanotechnological samples in comparison with the drug solutions. In conclusion, PN was considered to have the strongest potential as a novel oral formulation for pediatric HIV treatment |
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Palavras-Chave: |
Cubosomes; Nanoemulsion. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01966naa a2200253 a 4500
001 2152254
005 2024-11-28
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3390/nano13040770$2DOI
100 1 $aGUEDES, M. D. V.
245 $aLamivudine and Zidovudine-Loaded Nanostructures$bGreen Chemistry Preparation for Pediatric Oral Administration.$h[electronic resource]
260 $c2023
300 $a1 - 18
520 $aHere, we report on the development of lipid-based nanostructures containing zidovudine (1 mg/mL) and lamivudine (0.5 mg/mL) for oral administration in the pediatric population, eliminating the use of organic solvents, which is in accordance with green chemistry principles. The formulations were obtained by ultrasonication using monoolein (MN) or phytantriol (PN), which presented narrow size distributions with similar mean particle sizes (~150 nm) determined by laser diffraction. The zeta potential and the pH values of the formulations were around −4.0 mV and 6.0, respectively. MN presented a slightly higher incorporation rate compared to PN. Nanoemulsions were obtained when using monoolein, while cubosomes were obtained when using phytantriol, as confirmed by Small-Angle X-ray Scattering. The formulations enabled drug release control and protection against acid degradation. The drug incorporation was effective and the analyses using an electronic tongue indicated a difference in palatability between the nanotechnological samples in comparison with the drug solutions. In conclusion, PN was considered to have the strongest potential as a novel oral formulation for pediatric HIV treatment
653 $aCubosomes
653 $aNanoemulsion
700 1 $aMARQUES, M. S.
700 1 $aBERLITZ, S. J.
700 1 $aFACURE, M. H. M.
700 1 $aCORREA, D. S.
700 1 $aSTEFFENS, C.
700 1 $aCONTRI, R. V.
700 1 $aKÜLKAMP-GUERRREIRO, I. C.
773 $tNanomaterials$gv. 13, 770, 2023.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
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