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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
22/05/2025 |
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Data da última atualização: |
22/05/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SOUSA, A. L. M. de; PINHEIRO, R. R.; ARAÚJO, J. F.; PEIXOTO, R. M.; LIMA, A. M. C.; MORAIS, S. M. de; SOUZA, S. C. R.; AMARAL, G. P.; TEIXEIRA, M. F. da S.; ANDRIOLI, A. |
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Afiliação: |
ANA LÍDIA MADEIRA DE SOUSA, LUCIANO FEIJAO FACULTY; RAYMUNDO RIZALDO PINHEIRO, CNPC; JUSCILÂNIA FURTADO ARAÚJO, FACULDADE IEDUCARE FIED; RENATO MESQUITA PEIXOTO, CENTRO UNIVERSITÁRIO VALE DO SALGADO; ANA MILENA CÉSAR LIMA, REGIONAL SCIENTIFIC DEVELOPMENT SCHOLARSHIP OF NATIONAL SCIENTIFIC AND TECHNOLOGICAL DEVELOPMENT COUNCIL; SELENE MAIA DE MORAIS, STATE UNIVERSITY OF CEARÁ; SAMARA CRISTINA ROCHA SOUZA, UNIVERSITY OF HELSINKI; GABRIEL PAULA AMARAL, STATE UNIVERSITY VALE DO ACARAÚ; MARIA FÁTIMA DA SILVA TEIXEIRA, STATE UNIVERSITY OF CEARA; ALICE ANDRIOLI PINHEIRO, CNPC. |
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Título: |
Antiviral activity of Azadirachta indica A. Juss and Melia azedarach extracts during the replication cycle of small ruminant lentiviruses. |
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Ano de publicação: |
2025 |
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Fonte/Imprenta: |
Brazilian Journal of Microbiology, Apr. 2025. |
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DOI: |
10.1007/s42770-025-01659-0 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: This study aimed to evaluate the in vitro antiviral activity of ethanolic extracts from Azadirachta indica and Melia azedarach during the replication cycle of the CAEV-Cork and MVV-K1514 strains, both part of the small ruminant lentivirus (SRLV) group, in ovine third eyelid (OTE) cells. The crude extracts (CE), along with the ethyl acetate (EAF) and methanol (MF) organic fractions from these plants, were tested in treatments applied before, during, and after viral inoculation of the CAEV-Cork and MVV-K1514 strains in separate OTE cell cultures. Following these treatments, the most effective results were subjected to viral titration analysis. The findings indicate that the EAF of A. indica and M. azedarach may have reduced the viral titer of the CAEV-Cork strain by 316-fold after inoculation and by 1.995-fold when applied concomitantly with inoculation, respectively. For the MVV-K1514 strain, the EAF of A. indica achieved a 1,000-fold inhibition when applied simultaneously with viral inoculation. These results suggest that extracts from Meliaceae plants influenced all phases of the SRLV replication cycle, significantly inhibiting the activity of both viral strains, although complete viral elimination was not achieved. |
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Palavras-Chave: |
Caprine lentivirus; Crude extracts; Lentivirose; SRLV; Viral replication. |
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Thesagro: |
Azadirachta Indica; Caprino; Cinamomo; Extrato Vegetal; Fitoterapia; Melia Azedarach; Nim; Óleo Essencial; Ovino; Planta Medicinal. |
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Thesaurus Nal: |
Antiretroviral properties; Goat diseases; Goats; Lentivirus; Medicinal plants; Ovine lentivirus; Phytotherapy; Plant extracts; Sheep diseases. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02726naa a2200529 a 4500
001 2175876
005 2025-05-22
008 2025 bl uuuu u00u1 u #d
024 7 $a10.1007/s42770-025-01659-0$2DOI
100 1 $aSOUSA, A. L. M. de
245 $aAntiviral activity of Azadirachta indica A. Juss and Melia azedarach extracts during the replication cycle of small ruminant lentiviruses.$h[electronic resource]
260 $c2025
520 $aAbstract: This study aimed to evaluate the in vitro antiviral activity of ethanolic extracts from Azadirachta indica and Melia azedarach during the replication cycle of the CAEV-Cork and MVV-K1514 strains, both part of the small ruminant lentivirus (SRLV) group, in ovine third eyelid (OTE) cells. The crude extracts (CE), along with the ethyl acetate (EAF) and methanol (MF) organic fractions from these plants, were tested in treatments applied before, during, and after viral inoculation of the CAEV-Cork and MVV-K1514 strains in separate OTE cell cultures. Following these treatments, the most effective results were subjected to viral titration analysis. The findings indicate that the EAF of A. indica and M. azedarach may have reduced the viral titer of the CAEV-Cork strain by 316-fold after inoculation and by 1.995-fold when applied concomitantly with inoculation, respectively. For the MVV-K1514 strain, the EAF of A. indica achieved a 1,000-fold inhibition when applied simultaneously with viral inoculation. These results suggest that extracts from Meliaceae plants influenced all phases of the SRLV replication cycle, significantly inhibiting the activity of both viral strains, although complete viral elimination was not achieved.
650 $aAntiretroviral properties
650 $aGoat diseases
650 $aGoats
650 $aLentivirus
650 $aMedicinal plants
650 $aOvine lentivirus
650 $aPhytotherapy
650 $aPlant extracts
650 $aSheep diseases
650 $aAzadirachta Indica
650 $aCaprino
650 $aCinamomo
650 $aExtrato Vegetal
650 $aFitoterapia
650 $aMelia Azedarach
650 $aNim
650 $aÓleo Essencial
650 $aOvino
650 $aPlanta Medicinal
653 $aCaprine lentivirus
653 $aCrude extracts
653 $aLentivirose
653 $aSRLV
653 $aViral replication
700 1 $aPINHEIRO, R. R.
700 1 $aARAÚJO, J. F.
700 1 $aPEIXOTO, R. M.
700 1 $aLIMA, A. M. C.
700 1 $aMORAIS, S. M. de
700 1 $aSOUZA, S. C. R.
700 1 $aAMARAL, G. P.
700 1 $aTEIXEIRA, M. F. da S.
700 1 $aANDRIOLI, A.
773 $tBrazilian Journal of Microbiology, Apr. 2025.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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