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 | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
25/09/2023 |
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Data da última atualização: |
25/09/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GRIZZO, A.; SANTOS, D. M. dos; COSTA, V. P. V. da; LOPES, R. G.; INADA, N. M.; CORREA, D. S.; CAMPANA-FILHO, S. P. |
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Afiliação: |
Sao Carlos Institute of Chemistry/University of Sao Paulo; Nanotechnology National Laboratory for Agriculture (LNNA); Center for Exact Sciences and Technology, Federal University of Sao Carlos (UFSCar); Sao Carlos Institute of Physics/University of Sao Paulo; Sao Carlos Institute of Physics/University of Sao Paulo; DANIEL SOUZA CORREA, CNPDIA; CAMPANA-FILHO, S. P., Sao Carlos Institute of Chemistry/University of Sao Paulo. |
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Título: |
Multifunctional bilayer membranes composed of poly(lactic acid), beta-chitin whiskers and silver nanoparticles for wound dressing applications |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
International Journal of Biological Macromolecules, v. 251, 126314, 2023. |
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ISSN: |
0141-8130 |
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DOI: |
https://doi.org/10.1016/j.ijbiomac.2023.126314 |
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Idioma: |
Inglês |
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Conteúdo: |
Nanomaterial-based wound dressings have been extensively studied for the treatment of both minor and lifethreatening tissue injuries. These wound dressings must possess several crucial characteristics, such as tissue compatibility, non-toxicity, appropriate biodegradability to facilitate wound healing, effective antibacterial activity to prevent infection, and adequate physical and mechanical strength to withstand repetitive dynamic forces that could potentially disrupt the healing process. Nevertheless, the development of nanostructured wound dressings that incorporate various functional micro- and nanomaterials in distinct architectures, each serving specific purposes, presents significant challenges. In this study, we successfully developed a novel multifunctional wound dressing based on poly(lactic acid) (PLA) fibrous membranes produced by solution-blow spinning (SBS) and electrospinning. The PLA-based membranes underwent surface modifications aimed at tailoring their properties for utilization as effective wound dressing platforms. Initially, beta-chitin whiskers were deposited onto the membrane surface through filtration, imparting hydrophilic character. Afterward, silver nanoparticles (AgNPs) were incorporated onto the beta-chitin layer using a spray deposition method, resulting in platforms with antimicrobial properties against both Staphylococcus aureus and Escherichia coli. Cytotoxicity studies demonstrated the biocompatibility of the membranes with the neonatal human dermal fibroblast (HDFn) cell line. Moreover, bilayer membranes exhibited a high surface area and porosity (> 80%), remarkable stability in aqueous media, and favorable mechanical properties, making them promising candidates for application as multifunctional wound dressings. MenosNanomaterial-based wound dressings have been extensively studied for the treatment of both minor and lifethreatening tissue injuries. These wound dressings must possess several crucial characteristics, such as tissue compatibility, non-toxicity, appropriate biodegradability to facilitate wound healing, effective antibacterial activity to prevent infection, and adequate physical and mechanical strength to withstand repetitive dynamic forces that could potentially disrupt the healing process. Nevertheless, the development of nanostructured wound dressings that incorporate various functional micro- and nanomaterials in distinct architectures, each serving specific purposes, presents significant challenges. In this study, we successfully developed a novel multifunctional wound dressing based on poly(lactic acid) (PLA) fibrous membranes produced by solution-blow spinning (SBS) and electrospinning. The PLA-based membranes underwent surface modifications aimed at tailoring their properties for utilization as effective wound dressing platforms. Initially, beta-chitin whiskers were deposited onto the membrane surface through filtration, imparting hydrophilic character. Afterward, silver nanoparticles (AgNPs) were incorporated onto the beta-chitin layer using a spray deposition method, resulting in platforms with antimicrobial properties against both Staphylococcus aureus and Escherichia coli. Cytotoxicity studies demonstrated the biocompatibility of the membranes with the neonatal hu... Mostrar Tudo |
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Palavras-Chave: |
Beta-chitin whiskers; Biocompatible material; Electrospun nanofibers; Natural polymer; Solution blow spinning; Wound dressing. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02745naa a2200289 a 4500
001 2156857
005 2023-09-25
008 2023 bl uuuu u00u1 u #d
022 $a0141-8130
024 7 $ahttps://doi.org/10.1016/j.ijbiomac.2023.126314$2DOI
100 1 $aGRIZZO, A.
245 $aMultifunctional bilayer membranes composed of poly(lactic acid), beta-chitin whiskers and silver nanoparticles for wound dressing applications$h[electronic resource]
260 $c2023
520 $aNanomaterial-based wound dressings have been extensively studied for the treatment of both minor and lifethreatening tissue injuries. These wound dressings must possess several crucial characteristics, such as tissue compatibility, non-toxicity, appropriate biodegradability to facilitate wound healing, effective antibacterial activity to prevent infection, and adequate physical and mechanical strength to withstand repetitive dynamic forces that could potentially disrupt the healing process. Nevertheless, the development of nanostructured wound dressings that incorporate various functional micro- and nanomaterials in distinct architectures, each serving specific purposes, presents significant challenges. In this study, we successfully developed a novel multifunctional wound dressing based on poly(lactic acid) (PLA) fibrous membranes produced by solution-blow spinning (SBS) and electrospinning. The PLA-based membranes underwent surface modifications aimed at tailoring their properties for utilization as effective wound dressing platforms. Initially, beta-chitin whiskers were deposited onto the membrane surface through filtration, imparting hydrophilic character. Afterward, silver nanoparticles (AgNPs) were incorporated onto the beta-chitin layer using a spray deposition method, resulting in platforms with antimicrobial properties against both Staphylococcus aureus and Escherichia coli. Cytotoxicity studies demonstrated the biocompatibility of the membranes with the neonatal human dermal fibroblast (HDFn) cell line. Moreover, bilayer membranes exhibited a high surface area and porosity (> 80%), remarkable stability in aqueous media, and favorable mechanical properties, making them promising candidates for application as multifunctional wound dressings.
653 $aBeta-chitin whiskers
653 $aBiocompatible material
653 $aElectrospun nanofibers
653 $aNatural polymer
653 $aSolution blow spinning
653 $aWound dressing
700 1 $aSANTOS, D. M. dos
700 1 $aCOSTA, V. P. V. da
700 1 $aLOPES, R. G.
700 1 $aINADA, N. M.
700 1 $aCORREA, D. S.
700 1 $aCAMPANA-FILHO, S. P.
773 $tInternational Journal of Biological Macromolecules$gv. 251, 126314, 2023.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
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Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sul. |
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Data corrente: |
15/02/2012 |
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Data da última atualização: |
15/02/2012 |
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Tipo da produção científica: |
Comunicado Técnico/Recomendações Técnicas |
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Autoria: |
SILVA, G. M. da; MONTARDO, D. P.; MACHADO, L. J.; ZANCHIN, J. T.; LOPES, B. A.; PERONI, N. D.; MOTTA, J. C. S.; COSTA, P. U. N. da; UHDE, L. T.; MAIXNER, A. R. |
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Afiliação: |
GUSTAVO MARTINS DA SILVA, CPPSUL; DANIEL PORTELLA MONTARDO, CPPSUL; Lediomar José Machado, EMATER/RS-ASCAR; Joacir Tonin Zanchin, EMATER/RS-ASCAR; Bento Augusto Lopes, EMATER/RS-ASCAR; Neimar Damian Peroni, EMATER/RS-ASCAR; José Claudio Secchi Motta, EMATER/RS-ASCAR; Pedro Urubatan Neto da Costa, EMATER/RS-ASCAR; Leonir Terezinha Uhde, UNIJUÍ; Adriano Rudi Maixner, UNIJUÍ. |
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Título: |
Pastagem de Tifton 85 consorciado com forrageiras de inverno. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Bagé: Embrapa Pecuária Sul, 2011. |
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Páginas: |
8 p. |
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Série: |
(Embrapa Pecuária Sul. Comunicado técnico, 79). |
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Idioma: |
Português |
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Conteúdo: |
Experimento e Avaliações em Unidades de Produção; Manejo da Pastagem e Método de Semeadura de Forrageiras de Inverno; Época e Densidade de Semeadura; Produção da Pastagem Consorciada; Espécies de Inverno para o Consórcio. |
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Thesagro: |
Planta forrageira. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/54182/1/CO-79.pdf
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Marc: |
LEADER 00954nam a2200253 a 4500
001 1915675
005 2012-02-15
008 2011 bl uuuu u0uu1 u #d
100 1 $aSILVA, G. M. da
245 $aPastagem de Tifton 85 consorciado com forrageiras de inverno.$h[electronic resource]
260 $aBagé: Embrapa Pecuária Sul$c2011
300 $a8 p.
490 $a(Embrapa Pecuária Sul. Comunicado técnico, 79).
520 $aExperimento e Avaliações em Unidades de Produção; Manejo da Pastagem e Método de Semeadura de Forrageiras de Inverno; Época e Densidade de Semeadura; Produção da Pastagem Consorciada; Espécies de Inverno para o Consórcio.
650 $aPlanta forrageira
700 1 $aMONTARDO, D. P.
700 1 $aMACHADO, L. J.
700 1 $aZANCHIN, J. T.
700 1 $aLOPES, B. A.
700 1 $aPERONI, N. D.
700 1 $aMOTTA, J. C. S.
700 1 $aCOSTA, P. U. N. da
700 1 $aUHDE, L. T.
700 1 $aMAIXNER, A. R.
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