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Registro Completo |
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
11/09/2023 |
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Data da última atualização: |
11/09/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
JUNQUEIRA, D. M.; TOCHETTO, C.; ANDERSON, T. K.; GAVA, D.; HAACH, V.; CANTAO, M. E.; BAKER, A. L. V.; SCHAEFER, R. |
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Afiliação: |
DENNIS MALETICH JUNQUEIRA, Universidade Federal de Santa Maria; CAROLINE TOCHETTO; TAVIS K. ANDERSON, Virus and Prion Research Unit/USDA; DANIELLE GAVA, CNPSA; VANESSA HAACH, Universidade Federal do Rio Grande do Sul; MAURICIO EGIDIO CANTAO, CNPSA; AMY L. VINCENT BAKER, Virus and Prion Research Unit/USDA; REJANE SCHAEFER, CNPSA. |
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Título: |
Human-to-swine introductions and onward transmission of 2009 H1N1 pandemic influenza viruses in Brazil. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Frontiers in Microbiology, v. 14, article 1243567, 2023. |
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DOI: |
https://doi.org/10.3389/fmicb.2023.1243567 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Introduction: Once established in the human population, the 2009 H1N1 pandemic virus (H1N1pdm09) was repeatedly introduced into swine populations globally with subsequent onward transmission among pigs. Methods: To identify and characterize human-to-swine H1N1pdm09 introductions in Brazil, we conducted a large-scale phylogenetic analysis of 4,141 H1pdm09 hemagglutinin (HA) and 3,227 N1pdm09 neuraminidase (NA) gene sequences isolated globally from humans and swine between 2009 and 2022. Results: Phylodynamic analysis revealed that during the period between 2009 and 2011, there was a rapid transmission of the H1N1pdm09 virus from humans to swine in Brazil. Multiple introductions of the virus were observed, but most of them resulted in self-limited infections in swine, with limited onward transmission. Only a few sustained transmission clusters were identified during this period. After 2012, there was a reduction in the number of human-to-swine H1N1pdm09 transmissions in Brazil. Discussion: The virus underwent continuous antigenic drift, and a balance was established between swine-to-swine transmission and extinction, with minimal sustained onward transmission from humans to swine. These results emphasize the dynamic interplay between human-to-swine transmission, antigenic drift, and the establishment of swine-to-swine transmission in shaping the evolution and persistence of H1N1pdm09 in swine populations. |
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Palavras-Chave: |
H1N1; Spillover. |
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Thesagro: |
Contaminação; Suíno. |
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Thesaurus Nal: |
Brazil; Influenza A virus; Spreaders; Swine. |
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Categoria do assunto: |
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Marc: |
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Registro original: |
Embrapa Suínos e Aves (CNPSA) |
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