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| Registros recuperados : 16 | |
| 1. |  | AZEVEDO, C. F.; RESENDE, M. D. V. de; SILVA, F. F. e; LOPES, P. S.; GUIMARÃES, S. E. F. Regressão via componentes independentes aplicada à seleção genômica para características de carcaça em suínos. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 48, n. 6, p. 619-626, jun. 2013.| Biblioteca(s): Embrapa Florestas; Embrapa Unidades Centrais. |
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| 2. | | COSTA, E. V.; DINIZ, D. B.; VERONEZE, R.; RESENDE, M. D. V. de; AZEVEDO, C. F.; GUIMARÃES, S. E. F.; SILVA, F. F.; LOPES, P. S. Estimating additive and dominance variances for complex traits in pigs combining genomic and pedigree information. Genetics and Molecular Research, v. 14, n. 2, p. 6303-6311, June 2015.| Biblioteca(s): Embrapa Florestas. |
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| 3. | | PINHEIRO, V. R.; SILVA, F. F. e; GUIMARÃES, S. E. F.; RESENDE, M. D. V. de; LOPES, P. S.; CRUZ, C. D.; AZEVEDO, C. F. Mapeamento de QTL para características de crescimento de suínos por meio de modelos de regressão aleatória. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 48, n. 2, p. 190-196, fev. 2013.| Biblioteca(s): Embrapa Florestas; Embrapa Unidades Centrais. |
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| 4. | | VERARDO, L. L.; SILVA, F. F.; VARONA, L.; RESENDE, M. D. V. de; BASTIAANSEN, J. W. M.; LOPES, P. S.; GUIMARÃES, S. E. F. Bayesian GWAS and network analysis revealed new candidate genes for number of teats in pigs. Journal of Applied Genetics, v. 56, n. 1, p. 123-132, Feb. 2015.| Biblioteca(s): Embrapa Florestas. |
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| 5. | | AZEVEDO, C. F.; NASCIMENTO, M.; SILVA, F. F.; RESENDE, M. D. V. de; LOPES, P. S.; GUIMARÃES, S. E. F.; GLÓRIA, L. S. Comparison of dimensionality reduction methods to predict genomic breeding values for carcass traits in pigs. Genetics and Molecular Research, Ribeirão Preto, v. 14, n. 4, p. 12217-12227, 2015.| Biblioteca(s): Embrapa Florestas. |
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| 6. | | AZEVEDO, C. F.; SILVA, F. F. e; RESENDE, M. D. V. de; PETERNELLI, L. A.; GUIMARÃES, S. E. F.; LOPES, P. S. Quadrados mínimos parciais uni e multivariado aplicados na seleção genômica para características de carcaça em suínos. Ciência Rural, Santa Maria, RS, v. 43, n. 9, p. 1642-1649, set. 2013.| Biblioteca(s): Embrapa Florestas. |
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| 7. | | SANTOS, V. S.; MARTINS FILHO, S.; RESENDE, M. D. V. de; AZEVEDO, C. F.; LOPES, P. S.; GUIMARÃES, S. E. F.; SILVA, F. F. Genomic prediction for additive and dominance effects of censored traits in pigs. Genetics and Molecular Research, v. 15, n. 4, gmr15048764, Oct. 2016.| Biblioteca(s): Embrapa Florestas. |
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| 8. | | SANTOS, V. S.; MARTINS FILHO, S.; RESENDE, M. D. V. de; AZEVEDO, C. F.; LOPES, P. S.; GUIMARAES, S. E. F.; GLORIA, L. S.; SILVA, F. F. Genomic selection for slaughter age in pigs using the Cox frailty model. Genetics and Molecular Research, Ribeirão Preto, v. 14, n. 4, p. 12616-12627, 2015.| Biblioteca(s): Embrapa Florestas. |
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| 9. | | SILVA, F. F.; ROCHA, G. S.; RESENDE, M. D. V. de; GUIMARÃES, S. E. F.; PETERNELLI, L. A.; DUARTE, D. A. S.; AZEVEDO, C. Seleção genômica ampla para curvas de crescimento. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 65, n. 5, p. 1519-1526, 2013.| Biblioteca(s): Embrapa Florestas. |
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| 10. | | SILVA, F. F. e; ZAMBRANO, M. F. B.; VARONA, L.; GLÓRIA, L. S.; LOPES, P. S.; SILVA, M. V. G. B.; ARBEX, W. A.; LÁZARO, S. F.; RESENDE, M. D. V. de; GUIMARÃES, S. E. F. Genome association study through nonlinear mixed models revealed new candidate genes for pig growth curves. Scientia Agricola, v. 74, n. 1, 2017. 7 P.| Biblioteca(s): Embrapa Florestas; Embrapa Gado de Leite. |
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| 11. | | DUARTE, D. A. S.; FORTES, M. R. S.; DUARTE, M. de S.; GUIMARÃES, S. E. F.; VERARDO, L. L.; VERONEZE, R.; RIBEIRO, A. M. F.; LOPES, P. S.; RESENDE, M. D. V. de; SILVA, F. F. e. Genome-wide association studies, meta-analyses and derived gene network for meat quality and carcass traits in pigs. Animal Production Science, v. 58, n. 6, p. 1100-1008, May 2018.| Biblioteca(s): Embrapa Florestas. |
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| 12. | | SILVA, F. F.; JEREZ, E. A. Z.; RESENDE, M. D. V. de; VIANA, J. M. S.; AZEVEDO, C. F.; LOPES, P. S.; NASCIMENTO, M.; LIMA, R. O. de; GUIMARÃES, S. E. F. Bayesian model combining linkage and linkage disequilibrium analysis for low density-based genomic selection in animal breeding. Journal of Applied Animal Research, v. 46, n. 1, p. 873-878, 2018.| Biblioteca(s): Embrapa Florestas. |
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| 13. | | SILVA, F. F. e; RESENDE, M. D. V. de; ROCHA, G. S.; DUARTE, D. A. S.; LOPES, P. S.; BRUSTOLIN, O. J. B.; THUS, S.; VIANA, J. M. S.; GUIMARÃES, S. E. F. Genomic growth curves of an outbred pig population. Genetics and Molecular Biology, v. 36, n. 4, p. 520-527, 2013.| Biblioteca(s): Embrapa Florestas. |
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| 14. | | BARROSO, L. M. A.; NASCIMENTO, M.; NASCIMENTO, A. C. C.; SILVA, F. F.; SERÃO, N. V. L.; CRUZ, C. D.; RESENDE, M. D. V. de; SILVA, F. L.; AZEVEDO, C. F.; LOPES, P. S.; GUIMARÃES, S. E. F. Regularized quantile regression for SNP marker estimation of pig growth curves. Journal of Animal Science and Biotechnology, v. 8, n. 59, 2017. 9 p.| Biblioteca(s): Embrapa Florestas. |
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| 15. | | AZEVEDO, C. F.; SILVA, F. F.; RESENDE, M. D. V. de; LOPES, M. S.; DUIJVESTEINJN, N.; GUIMARÃES, S. E. F.; LOPES, P. S.; KELLY, M. J.; VIANA, J. M. S.; KNOL, E. F. Supervised independent component analysis as an alternative method for genomic selection in pigs. Journal of Animal Breeding and Genetics, v. 131, p. 452-461, 2014.| Biblioteca(s): Embrapa Florestas. |
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| 16. | | TEIXEIRA, F. R. F.; NASCIMENTO, M.; NASCIMENTO, A. C. C.; SILVA, F. F. e; CRUZ, C. D.; AZEVEDO, C. F.; PAIXÃO, D. M.; BARROSO, L. M. A.; VERARDO, L. L.; RESENDE, M. D. V. de; GUIMARÃES, S. E. F.; LOPES, P. S. Factor analysis applied to genome prediction for high-dimensional phenotypes in pigs. Genetics and Molecular Research, v. 15, n. 2, 2016. 10 p.| Biblioteca(s): Embrapa Florestas. |
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| Registros recuperados : 16 | |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
09/01/2020 |
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Data da última atualização: |
06/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
OTTO, P. I.; GUIMARÃES, S. E. F.; VERARDO, L. L.; AZEVEDO, A. L. S.; VANDENPLAS, J.; SEVILLANO, C. A.; MARQUES, D. B. D.; PIRES, M. de F. A.; FREITAS, C. de; VERNEQUE, R. da S.; MARTINS, M. F.; PANETTO, J. C. do C.; CARVALHO, W. A.; GOBO, D. O. R.; SILVA, M. V. G. B.; MACHADO, M. A. |
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Afiliação: |
ANA LUISA SOUSA AZEVEDO, CNPGL; MARIA DE FATIMA AVILA PIRES, CNPGL; CELIO DE FREITAS, CNPGL; RUI DA SILVA VERNEQUE, CNPGL; MARTA FONSECA MARTINS, CNPGL; JOAO CLAUDIO DO CARMO PANETTO, CNPGL; WANESSA ARAUJO CARVALHO, CNPGL; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; MARCO ANTONIO MACHADO, CNPGL. |
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Título: |
Genome-wide association studies for heat stress response in Bos taurus × Bos indicus crossbred cattle. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Journal of Dairy Science, v. 102, n. 9, p. 8148-8158, 2019. |
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DOI: |
https://doi.org/10.3168/jds.2018-15305 |
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Idioma: |
Inglês |
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Conteúdo: |
Heat stress is an important issue in the global dairy industry. In tropical areas, an alternative to overcome heat stress is the use of crossbred animals or synthetic breeds, such as the Girolando. In this study, we performed a genome-wide association study (GWAS) and post-GWAS analyses for heat stress in an experimental Gir × Holstein F2 population. Rectal temperature (RT) was measured in heat-stressed F2 animals, and the variation between 2 consecutive RT measurements (ΔRT) was used as the dependent variable. Illumina BovineSNP50v1 BeadChip (Illumina Inc., San Diego, CA) and single-SNP approach were used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene-transcription factor (TF) networks, generated from enriched TF. The breed origin of marker alleles in the F2 population was assigned using the breed of origin of alleles (BOA) approach. Heritability and repeatability estimates (± standard error) for ΔRT were 0.13 ± 0.08 and 0.29 ± 0.06, respectively. Association analysis revealed 6 SNP significantly associated with ΔRT. Genes involved with biological processes in response to heat stress effects (LIF, OSM, TXNRD2, and DGCR8) were identified as putative candidate genes. After performing the BOA approach, the 10% of F2 animals with the lowest breeding values for ΔRT were classified as low-ΔRT, and the 10% with the highest breeding values for ΔRT were classified as high-ΔRT. On average, 49.4% of low-ΔRT animals had 2 alleles from the Holstein breed (HH), and 39% had both alleles from the Gir breed (GG). In high-ΔRT animals, the average proportion of animals for HH and GG were 1.4 and 50.2%, respectively. This study allowed the identification of candidate genes for ΔRT in Gir × Holstein crossbred animals. According to the BOA approach, Holstein breed alleles could be associated with better response to heat stress effects, which could be explained by the fact that Holstein animals are more affected by heat stress than Gir animals and thus require a genetic architecture to defend the body from the deleterious effects of heat stress. Future studies can provide further knowledge to uncover the genetic architecture underlying heat stress in crossbred cattle. MenosHeat stress is an important issue in the global dairy industry. In tropical areas, an alternative to overcome heat stress is the use of crossbred animals or synthetic breeds, such as the Girolando. In this study, we performed a genome-wide association study (GWAS) and post-GWAS analyses for heat stress in an experimental Gir × Holstein F2 population. Rectal temperature (RT) was measured in heat-stressed F2 animals, and the variation between 2 consecutive RT measurements (ΔRT) was used as the dependent variable. Illumina BovineSNP50v1 BeadChip (Illumina Inc., San Diego, CA) and single-SNP approach were used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene-transcription factor (TF) networks, generated from enriched TF. The breed origin of marker alleles in the F2 population was assigned using the breed of origin of alleles (BOA) approach. Heritability and repeatability estimates (± standard error) for ΔRT were 0.13 ± 0.08 and 0.29 ± 0.06, respectively. Association analysis revealed 6 SNP significantly associated with ΔRT. Genes involved with biological processes in response to heat stress effects (LIF, OSM, TXNRD2, and DGCR8) were identified as putative candidate genes. After performing the BOA approach, the 10% of F2 animals with the lowest breeding values for ΔRT were classified as low-ΔRT, and the 10% with the highest breeding values for ΔRT were classified as high-ΔRT. On average, 49.4% of low-ΔR... Mostrar Tudo |
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Palavras-Chave: |
Crossbred cattle; Gene network; Post-GWAS analyses. |
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Thesaurus NAL: |
Heat stress. |
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Categoria do assunto: |
-- |
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Marc: |
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001 2118465
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008 2019 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3168/jds.2018-15305$2DOI
100 1 $aOTTO, P. I.
245 $aGenome-wide association studies for heat stress response in Bos taurus × Bos indicus crossbred cattle.$h[electronic resource]
260 $c2019
520 $aHeat stress is an important issue in the global dairy industry. In tropical areas, an alternative to overcome heat stress is the use of crossbred animals or synthetic breeds, such as the Girolando. In this study, we performed a genome-wide association study (GWAS) and post-GWAS analyses for heat stress in an experimental Gir × Holstein F2 population. Rectal temperature (RT) was measured in heat-stressed F2 animals, and the variation between 2 consecutive RT measurements (ΔRT) was used as the dependent variable. Illumina BovineSNP50v1 BeadChip (Illumina Inc., San Diego, CA) and single-SNP approach were used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene-transcription factor (TF) networks, generated from enriched TF. The breed origin of marker alleles in the F2 population was assigned using the breed of origin of alleles (BOA) approach. Heritability and repeatability estimates (± standard error) for ΔRT were 0.13 ± 0.08 and 0.29 ± 0.06, respectively. Association analysis revealed 6 SNP significantly associated with ΔRT. Genes involved with biological processes in response to heat stress effects (LIF, OSM, TXNRD2, and DGCR8) were identified as putative candidate genes. After performing the BOA approach, the 10% of F2 animals with the lowest breeding values for ΔRT were classified as low-ΔRT, and the 10% with the highest breeding values for ΔRT were classified as high-ΔRT. On average, 49.4% of low-ΔRT animals had 2 alleles from the Holstein breed (HH), and 39% had both alleles from the Gir breed (GG). In high-ΔRT animals, the average proportion of animals for HH and GG were 1.4 and 50.2%, respectively. This study allowed the identification of candidate genes for ΔRT in Gir × Holstein crossbred animals. According to the BOA approach, Holstein breed alleles could be associated with better response to heat stress effects, which could be explained by the fact that Holstein animals are more affected by heat stress than Gir animals and thus require a genetic architecture to defend the body from the deleterious effects of heat stress. Future studies can provide further knowledge to uncover the genetic architecture underlying heat stress in crossbred cattle.
650 $aHeat stress
653 $aCrossbred cattle
653 $aGene network
653 $aPost-GWAS analyses
700 1 $aGUIMARÃES, S. E. F.
700 1 $aVERARDO, L. L.
700 1 $aAZEVEDO, A. L. S.
700 1 $aVANDENPLAS, J.
700 1 $aSEVILLANO, C. A.
700 1 $aMARQUES, D. B. D.
700 1 $aPIRES, M. de F. A.
700 1 $aFREITAS, C. de
700 1 $aVERNEQUE, R. da S.
700 1 $aMARTINS, M. F.
700 1 $aPANETTO, J. C. do C.
700 1 $aCARVALHO, W. A.
700 1 $aGOBO, D. O. R.
700 1 $aSILVA, M. V. G. B.
700 1 $aMACHADO, M. A.
773 $tJournal of Dairy Science$gv. 102, n. 9, p. 8148-8158, 2019.
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