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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sul; Embrapa Pesca e Aquicultura. |
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Data corrente: |
16/02/2016 |
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Data da última atualização: |
16/02/2016 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BENAVIDES, M. V.; SONSTEGARD, T. S.; KEMP, S.; MUGAMBI, J. M.; GIBSON, J. P.; BAKER, R. L.; HANOTTE, O.; MARSHALL, K.; VAN TASSELL, C. |
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Afiliação: |
MAGDA VIEIRA BENAVIDES, CNPASA; TAD S. SONSTEGARD, USDA; STEPHEN KEMP, ILRI; JOHN M. MUGAMBI, KENYA AGRICULTURAL RESEARCH INSTITUTE; JOHN P. GIBSON, UNIVERSITY OF NEW ENGLAND; ROBERT LEYDEN BAKER, WAIKATO, NEW ZEALAND; OLIVIER HANOTTE, UNIVERSITY OF NOTTINGHAM; KAREN MARSHALL, ILRI; CURTIS VAN TASSELL, USDA. |
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Título: |
Identification of novel loci associated with gastrointestinal parasite resistance in a Red Maasai x Dorper backcross population. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
Plos One, v. 10, n. 4, e0122797, Apr. 2015. |
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DOI: |
10.1371/journal.pone.0122797 |
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Idioma: |
Inglês |
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Conteúdo: |
Gastrointestinal (GI) parasitic infection is the main health constraint for small ruminant production, causing loss of weight and/or death. Red Maasai sheep have adapted to a tropical environment where extreme parasite exposure is a constant, especially with highly pathogenic Haemonchus contortus. This breed has been reported to be resistant to gastrointestinal parasite infection, hence it is considered an invaluable resource to study associations between host genetics and resistance. The aim of this study was to identify polymorphisms strongly associated with host resistance in a double backcross population derived from Red Maasai and Dorper sheep using a SNP-based GWAS analysis. The animals that were genotyped represented the most resistant and susceptible individuals based on the tails of phenotypic distribution (10% each) for average faecal egg counts (AVFEC). AVFEC, packed cell volume (AVPCV), and live weight (AVLWT) were adjusted for fixed effects and co-variables, and an association analysis was run using EMMAX. Revised significance levels were calculated using 100,000 permutation tests. The top five significant SNP markers with - log10 p-values >3.794 were observed on five different chromosomes for AVFEC, and BLUPPf90/PostGSf90 results confirmed EMMAX significant regions for this trait. One of these regions included a cluster of significant SNP on chromosome (Chr) 6 not in linkage disequilibrium to each other. This genomic location contains annotated genes involved in cytokine signalling, haemostasis and mucus biosynthesis. Only one association detected on Chr 7 was significant for both AVPCV and AVLWT. The results generated here reveal candidate immune variants for genes involved in differential response to infection and provide additional SNP marker information that has potential to aid selection of resistance to gastrointestinal parasites in sheep of a similar genetic background to the double backcross population. MenosGastrointestinal (GI) parasitic infection is the main health constraint for small ruminant production, causing loss of weight and/or death. Red Maasai sheep have adapted to a tropical environment where extreme parasite exposure is a constant, especially with highly pathogenic Haemonchus contortus. This breed has been reported to be resistant to gastrointestinal parasite infection, hence it is considered an invaluable resource to study associations between host genetics and resistance. The aim of this study was to identify polymorphisms strongly associated with host resistance in a double backcross population derived from Red Maasai and Dorper sheep using a SNP-based GWAS analysis. The animals that were genotyped represented the most resistant and susceptible individuals based on the tails of phenotypic distribution (10% each) for average faecal egg counts (AVFEC). AVFEC, packed cell volume (AVPCV), and live weight (AVLWT) were adjusted for fixed effects and co-variables, and an association analysis was run using EMMAX. Revised significance levels were calculated using 100,000 permutation tests. The top five significant SNP markers with - log10 p-values >3.794 were observed on five different chromosomes for AVFEC, and BLUPPf90/PostGSf90 results confirmed EMMAX significant regions for this trait. One of these regions included a cluster of significant SNP on chromosome (Chr) 6 not in linkage disequilibrium to each other. This genomic location contains annotated genes involved i... Mostrar Tudo |
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Thesagro: |
Doença animal; Haemonchus Contortus; Nematoide; Ovelha. |
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Thesaurus Nal: |
Digestive system diseases; Sheep. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/139121/1/CNPASA-mvb.pdf
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Marc: |
LEADER 02850naa a2200301 a 4500
001 2037157
005 2016-02-16
008 2015 bl uuuu u00u1 u #d
024 7 $a10.1371/journal.pone.0122797$2DOI
100 1 $aBENAVIDES, M. V.
245 $aIdentification of novel loci associated with gastrointestinal parasite resistance in a Red Maasai x Dorper backcross population.$h[electronic resource]
260 $c2015
520 $aGastrointestinal (GI) parasitic infection is the main health constraint for small ruminant production, causing loss of weight and/or death. Red Maasai sheep have adapted to a tropical environment where extreme parasite exposure is a constant, especially with highly pathogenic Haemonchus contortus. This breed has been reported to be resistant to gastrointestinal parasite infection, hence it is considered an invaluable resource to study associations between host genetics and resistance. The aim of this study was to identify polymorphisms strongly associated with host resistance in a double backcross population derived from Red Maasai and Dorper sheep using a SNP-based GWAS analysis. The animals that were genotyped represented the most resistant and susceptible individuals based on the tails of phenotypic distribution (10% each) for average faecal egg counts (AVFEC). AVFEC, packed cell volume (AVPCV), and live weight (AVLWT) were adjusted for fixed effects and co-variables, and an association analysis was run using EMMAX. Revised significance levels were calculated using 100,000 permutation tests. The top five significant SNP markers with - log10 p-values >3.794 were observed on five different chromosomes for AVFEC, and BLUPPf90/PostGSf90 results confirmed EMMAX significant regions for this trait. One of these regions included a cluster of significant SNP on chromosome (Chr) 6 not in linkage disequilibrium to each other. This genomic location contains annotated genes involved in cytokine signalling, haemostasis and mucus biosynthesis. Only one association detected on Chr 7 was significant for both AVPCV and AVLWT. The results generated here reveal candidate immune variants for genes involved in differential response to infection and provide additional SNP marker information that has potential to aid selection of resistance to gastrointestinal parasites in sheep of a similar genetic background to the double backcross population.
650 $aDigestive system diseases
650 $aSheep
650 $aDoença animal
650 $aHaemonchus Contortus
650 $aNematoide
650 $aOvelha
700 1 $aSONSTEGARD, T. S.
700 1 $aKEMP, S.
700 1 $aMUGAMBI, J. M.
700 1 $aGIBSON, J. P.
700 1 $aBAKER, R. L.
700 1 $aHANOTTE, O.
700 1 $aMARSHALL, K.
700 1 $aVAN TASSELL, C.
773 $tPlos One$gv. 10, n. 4, e0122797, Apr. 2015.
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Registro original: |
Embrapa Pesca e Aquicultura (CNPASA) |
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Registro Completo
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
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Data corrente: |
13/01/2015 |
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Data da última atualização: |
03/06/2022 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
SILVA, A. S. S. da; BARRETO, M. C. S.; SANTOS JÚNIOR, A. C. dos; XAVIER JUNIOR, S. R.; SOUZA, H. J. R. |
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Afiliação: |
AMANDA SUELLEM SOARES DA SILVA, GRADUANDA UFRA; MAYRA CRISTIE SOUZA BARRETO; ADAILTON CUNHA DOS SANTOS JÚNIOR, Estudante da Escola Agroindustrial Juscelino Kubitscheck de Oliveira; SEBASTIAO RIBEIRO XAVIER JUNIOR, CPATU; HELENA JOSEANE RAIOL SOUZA, CPATU. |
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Título: |
Leguminosae L. na coleção de sementes do herbário IAN (Embrapa Amazônia Oriental) Belém, Pará, Brasil. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
In: CONGRESO LATINOAMERICANO DE BOTÁNICA, 11.; CONGRESSO NACIONAL DE BOTÂNICA, 65.; ENCONTRO REGIONAL DE BOTÂNICOS - MG, BA, ES, 34., 2014, Salvador. Botânica na América Latina: conhecimento, interação e difusão. Brasília, DF: SBS, 2014. |
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Idioma: |
Português |
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Palavras-Chave: |
Herbário IAN; Leguminosae L. |
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Thesagro: |
Semente. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/115393/1/8604-BTE.pdf
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Marc: |
LEADER 00796nam a2200181 a 4500
001 2005369
005 2022-06-03
008 2014 bl uuuu u00u1 u #d
100 1 $aSILVA, A. S. S. da
245 $aLeguminosae L. na coleção de sementes do herbário IAN (Embrapa Amazônia Oriental) Belém, Pará, Brasil.$h[electronic resource]
260 $aIn: CONGRESO LATINOAMERICANO DE BOTÁNICA, 11.; CONGRESSO NACIONAL DE BOTÂNICA, 65.; ENCONTRO REGIONAL DE BOTÂNICOS - MG, BA, ES, 34., 2014, Salvador. Botânica na América Latina: conhecimento, interação e difusão. Brasília, DF: SBS$c2014
650 $aSemente
653 $aHerbário IAN
653 $aLeguminosae L
700 1 $aBARRETO, M. C. S.
700 1 $aSANTOS JÚNIOR, A. C. dos
700 1 $aXAVIER JUNIOR, S. R.
700 1 $aSOUZA, H. J. R.
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Registro original: |
Embrapa Amazônia Oriental (CPATU) |
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