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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
22/11/2012 |
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Data da última atualização: |
14/04/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
YOUNG, N. D.; JEX, A. R.; LI, B.; LIU, S.; YANG, L.; XIONG, Z.; LI, Y.; CANTACESSI, C.; HALL, R. S.; XU, X.; CHEN, F.; WU, X.; ZERLOTINI, A.; OLIVEIRA, G.; HOFMANN, A.; ZHANG, G.; FANG, X.; KANG, Y.; CAMPBELL, B. E.; LOUKAS, A.; RANGANATHAN, S.; ROLLINSON, D.; RINALDI, G.; BRINDLEY, P. J.; YANG, H.; WANG, J.; WANG, J.; GASSER, R. B. |
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Afiliação: |
NEIL D. YOUNG, The University of Melbourn; AARON R. JEX, The University of Melbourn; BO LI, BGI-Shenzhen; SHIPING LIU, BGI-Shenzhen; LINFENG YANG, BGI-Shenzhen; ZIJUN XIONG, BGI-Shenzhen; YIUNGRUI LI, BGI-Shenzhen; CINZIA CANTACESSI, The University of Melbourn; ROSS S. HALL, The University of Melbourn; XUN XU, BGI-Shenzhen; FANGYUAN CHEN, BGI-Shenzhen; XUAN WU, BGI-Shenzhen; ADHEMAR ZERLOTINI NETO, CNPTIA; GUILHERME OLIVEIRA, Instituto de Pesquisa René Rachou-Fiocruz; ANDREAS HOFMANN, The University of Melbourn, Griffith University; GUOJIE ZHANG, BGI-Shenzhen; XIAODONG FANG, BGI-Shenzhen; YI FANG, BGI-Shenzhen; BRONWYN E. CAMPBELL, The University of Melbourne; ALEX LOUKAS, James Cook University; SHOBA RANGANATHAN, Macquarie University, National University of Singapore; DAVID ROLLINSON, Natural History Museum, London; GABRIEL RINALDI, Universidad de la República, Montevideo, George Washington University; PAUL BRINDLEY, George Washington University; HUANMING YANG, BGI-Shenzhen; JUN WANG, BGI-Shenzhen; JIAN WANG, BGI-Shenzhen; ROBIN B. GASSER, The University of Melbourne. |
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Título: |
Whole-genome sequence of Schistosoma haematobium. |
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Ano de publicação: |
2012 |
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Fonte/Imprenta: |
Nature Genetics, v. 44, n. 2, p. 221-225, Feb. 2012. |
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DOI: |
10.1038/ng.1065 |
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Idioma: |
Inglês |
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Conteúdo: |
Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide1. No vaccines are available, and treatment relies on one drug, praziquantel2. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer1,3 and as a predisposing factor for HIV/AIDS4,5. The parasite is transmitted to humans from freshwater snails1. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease6 and induce squamous cell carcinoma7. Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based technology at 74-fold coverage and compared it to sequences from related parasites8,9. We included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventions. |
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Palavras-Chave: |
Sequência genômica. |
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Thesaurus Nal: |
Genome; Schistosoma haematobium. |
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Categoria do assunto: |
-- |
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Marc: |
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024 7 $a10.1038/ng.1065$2DOI
100 1 $aYOUNG, N. D.
245 $aWhole-genome sequence of Schistosoma haematobium.$h[electronic resource]
260 $c2012
520 $aSchistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide1. No vaccines are available, and treatment relies on one drug, praziquantel2. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer1,3 and as a predisposing factor for HIV/AIDS4,5. The parasite is transmitted to humans from freshwater snails1. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease6 and induce squamous cell carcinoma7. Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based technology at 74-fold coverage and compared it to sequences from related parasites8,9. We included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventions.
650 $aGenome
650 $aSchistosoma haematobium
653 $aSequência genômica
700 1 $aJEX, A. R.
700 1 $aLI, B.
700 1 $aLIU, S.
700 1 $aYANG, L.
700 1 $aXIONG, Z.
700 1 $aLI, Y.
700 1 $aCANTACESSI, C.
700 1 $aHALL, R. S.
700 1 $aXU, X.
700 1 $aCHEN, F.
700 1 $aWU, X.
700 1 $aZERLOTINI, A.
700 1 $aOLIVEIRA, G.
700 1 $aHOFMANN, A.
700 1 $aZHANG, G.
700 1 $aFANG, X.
700 1 $aKANG, Y.
700 1 $aCAMPBELL, B. E.
700 1 $aLOUKAS, A.
700 1 $aRANGANATHAN, S.
700 1 $aROLLINSON, D.
700 1 $aRINALDI, G.
700 1 $aBRINDLEY, P. J.
700 1 $aYANG, H.
700 1 $aWANG, J.
700 1 $aWANG, J.
700 1 $aGASSER, R. B.
773 $tNature Genetics$gv. 44, n. 2, p. 221-225, Feb. 2012.
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