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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
20/12/2011 |
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Data da última atualização: |
05/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BRUGIOLO, A. S. S.; ALVES, C. C. de S.; GOUVEIA, A. C. C.; DIAS, A. T.; RODRIGUES, M. F.; PACÍFICO, L. G. G.; AARESTRUP, B. J. V.; MACHADO, M. A.; DOMINGUES, R.; TEIXEIRA, H. C.; GAMEIRO, J.; FERREIRA, A. P. |
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Afiliação: |
ALESSA SIN SINGER BRUGIOLO, UFJF; CAIO CÉSAR DE SOUZA ALVES, UFJF; ANA CLÁUDIA CARVALHO GOUVEIA, UFJF; ALYRIA TEIXEIRA DIAS, UFJF; MICHELE FERNANDES RODRIGUES, UFJF; LUCILA GROSSI GONÇALVES PACÍFICO, FIOCRUZ; BEATRIZ JULIÃO VIEIRA AARESTRUP, UFJF; MARCO ANTONIO MACHADO, CNPGL; ROBERT DOMINGUES, UFJF; HENRIQUE COUTO TEIXEIRA, UFJF; JACY GAMEIRO, UFJF; ANA PAULA FERREIRA, UFJF. |
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Título: |
Effects of aqueous extract of Echinodorus grandiflorus on the immune response in ovalbumin-induced pulmonary allergy. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Annals of Allergy, Asthma & Immunology, v. 106, n. 6, p. 481-488, 2011. |
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DOI: |
https://doi.org/10.1016/j.anai.2011.01.008 |
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Idioma: |
Inglês |
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Conteúdo: |
Background - Asthma is a disease characterized by intermittent obstruction of the airways and chronic inflammation that affects approximately 300 million people worldwide. The immune response in asthma is predominantly TH2, with high levels of total and allergen-specific IgE and bronchial eosinophilia. Asthma treatment is aimed at controlling the disease, and the drugs used currently have systemic adverse effects and generally are not effective in difficult-to-control cases. Objective - To investigate the effect of aqueous extract of Echinodorus grandiflorus, a plant used in folk medicine for its diuretic and anti-inflammatory properties, in a model of pulmonary allergy. Methods - BALB/c mice were intraperitoneally sensitized and nasally challenged with ovalbumin. Aqueous extract and dexamethasone treatments (0.1 mL/d per mouse) were initiated on day 32 and concluded on day 40. Eight hours after the last challenge evaluations, of serum, bronchoalveolar lavage, and lung tissue were performed. Results - Oral treatment with the extract markedly reduced the number of total cells and eosinophils in bronchoalveolar lavage. The eosinophil peroxidase activity in lung tissue, the levels of ovalbumin-specific IgE in serum, the levels of CCL11, and the gene expression of interleukin 4 and interleukin 13 in lung tissue were also lower after treatment. Conclusions - These results suggest that the aqueous extract of E grandiflorus is able to modulate allergic pulmonary inflammation and may be useful as a potential therapeutic agent for asthma. MenosBackground - Asthma is a disease characterized by intermittent obstruction of the airways and chronic inflammation that affects approximately 300 million people worldwide. The immune response in asthma is predominantly TH2, with high levels of total and allergen-specific IgE and bronchial eosinophilia. Asthma treatment is aimed at controlling the disease, and the drugs used currently have systemic adverse effects and generally are not effective in difficult-to-control cases. Objective - To investigate the effect of aqueous extract of Echinodorus grandiflorus, a plant used in folk medicine for its diuretic and anti-inflammatory properties, in a model of pulmonary allergy. Methods - BALB/c mice were intraperitoneally sensitized and nasally challenged with ovalbumin. Aqueous extract and dexamethasone treatments (0.1 mL/d per mouse) were initiated on day 32 and concluded on day 40. Eight hours after the last challenge evaluations, of serum, bronchoalveolar lavage, and lung tissue were performed. Results - Oral treatment with the extract markedly reduced the number of total cells and eosinophils in bronchoalveolar lavage. The eosinophil peroxidase activity in lung tissue, the levels of ovalbumin-specific IgE in serum, the levels of CCL11, and the gene expression of interleukin 4 and interleukin 13 in lung tissue were also lower after treatment. Conclusions - These results suggest that the aqueous extract of E grandiflorus is able to modulate allergic pulmonary inflammation and ma... Mostrar Tudo |
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Palavras-Chave: |
Allergic pulmonary inflammation. |
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Thesaurus Nal: |
Asthma; Immune response. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02517naa a2200301 a 4500
001 1910453
005 2024-02-05
008 2011 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.anai.2011.01.008$2DOI
100 1 $aBRUGIOLO, A. S. S.
245 $aEffects of aqueous extract of Echinodorus grandiflorus on the immune response in ovalbumin-induced pulmonary allergy.$h[electronic resource]
260 $c2011
520 $aBackground - Asthma is a disease characterized by intermittent obstruction of the airways and chronic inflammation that affects approximately 300 million people worldwide. The immune response in asthma is predominantly TH2, with high levels of total and allergen-specific IgE and bronchial eosinophilia. Asthma treatment is aimed at controlling the disease, and the drugs used currently have systemic adverse effects and generally are not effective in difficult-to-control cases. Objective - To investigate the effect of aqueous extract of Echinodorus grandiflorus, a plant used in folk medicine for its diuretic and anti-inflammatory properties, in a model of pulmonary allergy. Methods - BALB/c mice were intraperitoneally sensitized and nasally challenged with ovalbumin. Aqueous extract and dexamethasone treatments (0.1 mL/d per mouse) were initiated on day 32 and concluded on day 40. Eight hours after the last challenge evaluations, of serum, bronchoalveolar lavage, and lung tissue were performed. Results - Oral treatment with the extract markedly reduced the number of total cells and eosinophils in bronchoalveolar lavage. The eosinophil peroxidase activity in lung tissue, the levels of ovalbumin-specific IgE in serum, the levels of CCL11, and the gene expression of interleukin 4 and interleukin 13 in lung tissue were also lower after treatment. Conclusions - These results suggest that the aqueous extract of E grandiflorus is able to modulate allergic pulmonary inflammation and may be useful as a potential therapeutic agent for asthma.
650 $aAsthma
650 $aImmune response
653 $aAllergic pulmonary inflammation
700 1 $aALVES, C. C. de S.
700 1 $aGOUVEIA, A. C. C.
700 1 $aDIAS, A. T.
700 1 $aRODRIGUES, M. F.
700 1 $aPACÍFICO, L. G. G.
700 1 $aAARESTRUP, B. J. V.
700 1 $aMACHADO, M. A.
700 1 $aDOMINGUES, R.
700 1 $aTEIXEIRA, H. C.
700 1 $aGAMEIRO, J.
700 1 $aFERREIRA, A. P.
773 $tAnnals of Allergy, Asthma & Immunology$gv. 106, n. 6, p. 481-488, 2011.
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Embrapa Gado de Leite (CNPGL) |
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| Registros recuperados : 6 | |
| 1. |  | ARRUDA, C. E. de M.; DIAS, N. da S.; BLANCO, F. F.; SOUSA NETO, O. N. de; FERREIRA NETO, M. Bell pepper cultivation with brine from brackish water desalination. Revista Caatinga, Mossoró, v. 24, n. 2, p. 197-201, abr./jun. 2011.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 4 |
| Biblioteca(s): Embrapa Meio-Norte. |
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| 2. | | DIAS, N. da S.; OLIVEIRA, A. M. de; SOUSA NETO, O. N. de; BLANCO, F. F.; REBOUÇAS, J. R. L. Concentração salina e fases de exposição à salinidade do meloeiro cultivado em substrato de fibra de coco. Revista Brasileira de Fruticultura, Jaboticabal, v. 33, n. 3, p. 915-921, set. 2011.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Meio-Norte. |
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| 3. | | PORTELA, J. C.; CINTRA, F. L. D.; CARVALHO, H. W. L. de; ANJOS, J. L. dos; SOUSA NETO, O. N. de; MELO, P. de O. Caracterização física do solo em assentamento rural na zona agreste de Sergipe. In: CONGRESSO BRASILEIRO DE CIÊNCIA DO SOLO, 33., 2011, Uberlândia. Solos nos biomas brasileiros: sustentabilidade e mudanças climáticas: anais. [Uberlândia]: SBCS: UFU, ICIAG, 2011. Resumo expandido.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| 4. | | PORTELA, J. C.; CINTRA, F. L. D.; CARVALHO, H. W. L. de; ANJOS, J. L. dos; MELO, P. de O.; SOUSA NETO, O. N. de. Aributos físicos em um cambissolo da reigão do agreste sergipano. In: CONGRESSO BRASILEIRO DE CIÊNCIA DO SOLO, 33., 2011, Uberlândia. Solos nos biomas brasileiros: sustentabilidade e mudanças climáticas: anais. [Uberlândia]: SBCS: UFU, ICIAG, 2011. Resumo expandido.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| 5. | | GOMES, J. W. da S.; DIAS, N. da S.; OLIVEIRA, A. M. de; BLANCO, F. F.; SOUSA NETO, O. N. de. Crescimento e produção de tomate cereja em sistema hidropônico com rejeito de dessalinização. Revista Ciência Agronômica, Fortaleza, v. 42, n. 4, p. 850-856, out./dez. 2011.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 2 |
| Biblioteca(s): Embrapa Meio-Norte. |
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| 6. | | OLIVEIRA, F. R. A. de; COSTA, M. C. G.; SOUZA, H. A. de; SOUZA, J. M. S.; SOUSA NETO, O. N. de; FERNANDES, J. K. S. Desenvolvimento do milho cultivado em solo degradado enriquecido com resíduos de leguminosas arbóreas. In: CONGRESSO BRASILEIRO DE CIÊNCIAS DO SOLO, 34., 2013, Florianópolis. Anais... Viçosa, MG: Sociedade Brasileira de Ciência do Solo, 2013. 4 f.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| Registros recuperados : 6 | |
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