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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
04/10/2011 |
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Data da última atualização: |
23/09/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BRINGHENTI, I.; SCHULTZA, A.; RACHIDA, T.; BOMFIM, M. A. D.; MANDARIM-DE-LACERDA, C. A.; AGUILA, M. B. |
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Afiliação: |
Isabele Bringhenti, Laboratory of Morphometry, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, RJ.; Alini Schultza; Tamiris Rachida; MARCO AURELIO DELMONDES BOMFIM, CNPC; Carlos A. Mandarim-de-Lacerda; Marcia B. Aguila. |
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Título: |
An early fish oil-enriched diet reverses biochemical, liver and adipose tissue alterations in male offspring from maternal protein restriction in mice. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
The Journal of Nutritional Biochemistry, v. 22, n. 11, p. 1009-1014, Nov. 2011. |
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Idioma: |
Inglês |
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Conteúdo: |
Fetal programming is linked to adulthood metabolic and chronic diseases. We hypothesized that early fish oil (FO) intake would revert the programming responses in adult offspring. Pregnant mice were fed either standard chow (SC) or a low-protein diet (LP) throughout pregnancy/lactation. At weaning, the following groups were formed: SC and SC-FO, LP and LP-FO, which were fed SC or SC+FO, respectively. The LP offspring are predisposed to becoming fat, hypercholesterolemic and hyperglycemic. In addition, during adulthood, they become hypertensive with hepatic steatosis and have a high level of sterol regulatory element binding protein (SREBP-1). However, LP offspring that were fed an FO-enriched diet have decreased body mass (BM) gain and lower final BM. In addition, with this diet, these mice have improved lipid metabolism with a decrease in total cholesterol (TC) and triacylglyceride (TG) levels, reduced fat pad masses and reduced adipocyte size. Furthermore, these LP offspring show reduced liver structural damage of alanine aminotransferase (ALT), liver steatosis with low SREBP-1 protein expression and high peroxisome proliferator activity receptor-alpha expression, and improvement of blood pressure (BP) and tumor necrosis factor (TNF)-alpha level. Early fish oil intake has beneficial effects on the programming responses that control body fat pad, glucose and lipid metabolism, and liver and adipose tissue structure in adult programmed offspring. |
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Palavras-Chave: |
Fígado gorduroso; Fish oil; Hipertensão; Óleo de peixe; Protein restriction; Resistência a insulina; Restrição proteíca. |
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Thesagro: |
Obesidade. |
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Thesaurus Nal: |
Fatty liver; Hypertension; Insulin resistance; Obesity. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02485naa a2200325 a 4500
001 1902197
005 2019-09-23
008 2011 bl uuuu u00u1 u #d
100 1 $aBRINGHENTI, I.
245 $aAn early fish oil-enriched diet reverses biochemical, liver and adipose tissue alterations in male offspring from maternal protein restriction in mice.$h[electronic resource]
260 $c2011
520 $aFetal programming is linked to adulthood metabolic and chronic diseases. We hypothesized that early fish oil (FO) intake would revert the programming responses in adult offspring. Pregnant mice were fed either standard chow (SC) or a low-protein diet (LP) throughout pregnancy/lactation. At weaning, the following groups were formed: SC and SC-FO, LP and LP-FO, which were fed SC or SC+FO, respectively. The LP offspring are predisposed to becoming fat, hypercholesterolemic and hyperglycemic. In addition, during adulthood, they become hypertensive with hepatic steatosis and have a high level of sterol regulatory element binding protein (SREBP-1). However, LP offspring that were fed an FO-enriched diet have decreased body mass (BM) gain and lower final BM. In addition, with this diet, these mice have improved lipid metabolism with a decrease in total cholesterol (TC) and triacylglyceride (TG) levels, reduced fat pad masses and reduced adipocyte size. Furthermore, these LP offspring show reduced liver structural damage of alanine aminotransferase (ALT), liver steatosis with low SREBP-1 protein expression and high peroxisome proliferator activity receptor-alpha expression, and improvement of blood pressure (BP) and tumor necrosis factor (TNF)-alpha level. Early fish oil intake has beneficial effects on the programming responses that control body fat pad, glucose and lipid metabolism, and liver and adipose tissue structure in adult programmed offspring.
650 $aFatty liver
650 $aHypertension
650 $aInsulin resistance
650 $aObesity
650 $aObesidade
653 $aFígado gorduroso
653 $aFish oil
653 $aHipertensão
653 $aÓleo de peixe
653 $aProtein restriction
653 $aResistência a insulina
653 $aRestrição proteíca
700 1 $aSCHULTZA, A.
700 1 $aRACHIDA, T.
700 1 $aBOMFIM, M. A. D.
700 1 $aMANDARIM-DE-LACERDA, C. A.
700 1 $aAGUILA, M. B.
773 $tThe Journal of Nutritional Biochemistry$gv. 22, n. 11, p. 1009-1014, Nov. 2011.
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