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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
17/03/2011 |
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Data da última atualização: |
15/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
RINALDI, M.; LI, R. W.; BANNERMAN, D. D.; DANIELS, K. M.; EVOCK-CLOVER, C.; SILVA, M. V. G. B.; PAAPE, M. J.; RYSSEN, B. V.; BURVENICH, C.; CAPUCO, A. V. |
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Afiliação: |
MANUELA RINALDI, USDA-ARS; ROBERT W. LI, USDA-ARS; DOUGLAS D. BANNERMAN, USDA-ARS; KRISTY M. DANIELS, USDA-ARS; CHRISTINA EVOCK-CLOVER, USDA-ARS; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; MAX J. PAAPE, USDA-ARS; BERNADETTE VAN RYSSEN, GHENT UNIVERSITY, BELGIUM; CHRISTIAN BURVENICH, GHENT UNIVERSITY, BELGIUM; ANTHONY V. CAPUCO, USDA-ARS. |
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Título: |
A sentinel function for teat tissues in dairy cows: dominant innate immune response elements define early response to E. coli mastitis. |
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Ano de publicação: |
2010 |
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Fonte/Imprenta: |
Functional & integrative genomics, v. 10, n. 1, p. 21-38, 2010. |
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DOI: |
https://doi.org/10.1007/s10142-009-0133-z |
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Idioma: |
Inglês |
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Conteúdo: |
Escherichia coli intramammary infection elicits localized and systemic responses, some of which have been characterized in mammary secretory tissue. Our objective was to characterize gene expression patterns that become activated in different regions of the mammary gland during the acute phase of experimentally induced E. coli mastitis. Tissues evaluated were from Fürstenburg's rosette, teat cistern (TC), gland cistern (GC), and lobulo-alveolar (LA) regions of control and infected mammary glands, 12 and 24 h after bacterial (or control) infusions. The main networks activated by E. coli infection pertained to immune and inflammatory response, with marked induction of genes encoding proteins that function in chemotaxis and leukocyte activation and signaling. Genomic response at 12 h post-infection was greatest in tissues of the TC and GC. Only at 24 h post-infection did tissue from the LA region respond, at which time the response was the greatest of all regions. Similar genetic networks were impacted in all regions during early phases of intramammary infection, although regional differences throughout the gland were noted. Data support an important sentinel function for the teat, as these tissues responded rapidly and intensely, with production of cytokines and antimicrobial peptides. |
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Palavras-Chave: |
Dairy cow; Microarray; Network; QTR-PCR. |
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Thesagro: |
Escherichia Coli. |
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Thesaurus Nal: |
mastitis. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
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001 1881361
005 2024-02-15
008 2010 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s10142-009-0133-z$2DOI
100 1 $aRINALDI, M.
245 $aA sentinel function for teat tissues in dairy cows$bdominant innate immune response elements define early response to E. coli mastitis.$h[electronic resource]
260 $c2010
520 $aEscherichia coli intramammary infection elicits localized and systemic responses, some of which have been characterized in mammary secretory tissue. Our objective was to characterize gene expression patterns that become activated in different regions of the mammary gland during the acute phase of experimentally induced E. coli mastitis. Tissues evaluated were from Fürstenburg's rosette, teat cistern (TC), gland cistern (GC), and lobulo-alveolar (LA) regions of control and infected mammary glands, 12 and 24 h after bacterial (or control) infusions. The main networks activated by E. coli infection pertained to immune and inflammatory response, with marked induction of genes encoding proteins that function in chemotaxis and leukocyte activation and signaling. Genomic response at 12 h post-infection was greatest in tissues of the TC and GC. Only at 24 h post-infection did tissue from the LA region respond, at which time the response was the greatest of all regions. Similar genetic networks were impacted in all regions during early phases of intramammary infection, although regional differences throughout the gland were noted. Data support an important sentinel function for the teat, as these tissues responded rapidly and intensely, with production of cytokines and antimicrobial peptides.
650 $amastitis
650 $aEscherichia Coli
653 $aDairy cow
653 $aMicroarray
653 $aNetwork
653 $aQTR-PCR
700 1 $aLI, R. W.
700 1 $aBANNERMAN, D. D.
700 1 $aDANIELS, K. M.
700 1 $aEVOCK-CLOVER, C.
700 1 $aSILVA, M. V. G. B.
700 1 $aPAAPE, M. J.
700 1 $aRYSSEN, B. V.
700 1 $aBURVENICH, C.
700 1 $aCAPUCO, A. V.
773 $tFunctional & integrative genomics$gv. 10, n. 1, p. 21-38, 2010.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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