Registro Completo |
Biblioteca(s): |
Embrapa Pantanal. |
Data corrente: |
04/05/1999 |
Data da última atualização: |
04/05/1999 |
Autoria: |
LEWONTIN, R. C.; HUBBY, J. L. |
Afiliação: |
Department of Zoology, University of Chicago (Chicago, Illinois). |
Título: |
A molecular approach to the study of genic heterozygosity in natural populations. II. Amount of variation and degree of heterozygosity in natural populations of Drosophila pseudoobscura. |
Ano de publicação: |
1966 |
Fonte/Imprenta: |
Genetics, v.54, p.595-609, 1966. |
Idioma: |
Inglês |
Conteúdo: |
As pointed out in the first paper of this series (Hubby and Lewontin 1966), no one knows at the present time the kinds and frequencies of variant alleles present in natural populations of any organism, with the exception of certain special classes of genes. For human populations we know a good deal about certain polymorphisms for blood cell antifens, serum proteins, and metabolic disorders of various kinds but we can hardly regard theses, a priori, as typical of the genome as a whole. Clearly we need a method that will randomly sample the genome and detect a major proportion of the individual allelic substitutions that are segregating in a population. In our previous paper, we discussed a method for accomplishing this end by means of a study of electrophoretic variants at a large number of loci and we showed that the variation picked up by this method behaves in a simple Mendelin fashion so that phenotypes can be equated to hemozygous and heterozygous genotypes at single loci. |
Palavras-Chave: |
Estudo genetico; Mosca-da-fruta; Natural population; Populacao natural; Populations; Study of genic. |
Thesagro: |
Genética; População. |
Thesaurus Nal: |
Drosophila pseudoobscura; genetics. |
Categoria do assunto: |
-- |
Marc: |
LEADER 01775naa a2200253 a 4500 001 1795574 005 1999-05-04 008 1966 bl --- 0-- u #d 100 1 $aLEWONTIN, R. C. 245 $aA molecular approach to the study of genic heterozygosity in natural populations. II. Amount of variation and degree of heterozygosity in natural populations of Drosophila pseudoobscura. 260 $c1966 520 $aAs pointed out in the first paper of this series (Hubby and Lewontin 1966), no one knows at the present time the kinds and frequencies of variant alleles present in natural populations of any organism, with the exception of certain special classes of genes. For human populations we know a good deal about certain polymorphisms for blood cell antifens, serum proteins, and metabolic disorders of various kinds but we can hardly regard theses, a priori, as typical of the genome as a whole. Clearly we need a method that will randomly sample the genome and detect a major proportion of the individual allelic substitutions that are segregating in a population. In our previous paper, we discussed a method for accomplishing this end by means of a study of electrophoretic variants at a large number of loci and we showed that the variation picked up by this method behaves in a simple Mendelin fashion so that phenotypes can be equated to hemozygous and heterozygous genotypes at single loci. 650 $aDrosophila pseudoobscura 650 $agenetics 650 $aGenética 650 $aPopulação 653 $aEstudo genetico 653 $aMosca-da-fruta 653 $aNatural population 653 $aPopulacao natural 653 $aPopulations 653 $aStudy of genic 700 1 $aHUBBY, J. L. 773 $tGenetics$gv.54, p.595-609, 1966.
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Embrapa Pantanal (CPAP) |
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