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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
06/11/2002 |
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Data da última atualização: |
06/11/2002 |
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Autoria: |
DALEY, C. A.; SAKURAI, H.; ADAMS, B. M.; ADAMS, T. E. |
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Título: |
Effect of stress-like concentrations of cortisol on gonadotroph function in orchidectomized sheep. |
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Ano de publicação: |
1999 |
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Fonte/Imprenta: |
Biology of Reproduction, v. 60, n. 1, p. 158-163, 1999. |
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Idioma: |
Inglês |
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Conteúdo: |
The effect of stress-like concentrations of cortisol (C) on the feedback potency of estradiol (E,) was assessed using 32 orchidectomized sheep (wethers) assigned at random to 1 of 4 treatment groups in a 2 x 2 factorial design. Wethers received C (3.6 mg/50 kg per hour; groups 2 and 4) or a comparable volume of C delivery vehicle (groups 1 and 3) as a continuous infusion for 7 days. During the final 48 h of infusion, wethers received E2 (0.3 ug/50 kg/h; groups 3 and 4) or E2 delivery vehicle (groups 1 and 2). The pattern of LH secretion was assessed during a 4 h period of intensive blood collection beginning 44 h after initiation of E2 infusion. Gonadotroph responsiveness (LH secretion induced by GnRH challenge [500 ng, i.v.]) was determined 48 h after E2 delivery was begun. Although lhe frequency of secretory episodes of LH was not affected (p > 0.05) by infusion of C or E2 alone, LH pulse frequency was significantly decreased in wethers receiving C and E2 in combination. In contrast, neither the magnitude of basal gonadotroph responsiveness nor the extent of E2-dependent augmentation of responsiveness was significantly affected by stress-like concentrations of C. In a second experiment, the effect of C on the magnitude of E2-induced in- crease in pituitary concentration of GnRH receptor and GnRH receptor mRNA was assessed using 32 additional wethers. Continuous infusion of E2 for 48 h increased (p < 0.05) tissue concentrations of GnRH receptor and GnRH receptor mRNA. Con- current delivery of C did not affect (p > 0.05) E2-induced in- crease in GnRH receptor mRNA but significantly reduced the magnitude of the E2-dependent increase in pituitary concentration of GnRH receptor. Collectively, these data indicate that stress-like concentrations of C enhance the negative feedback potency of E2 and reduce estrogen-dependent augmentation of the concentration of GnRH receptor in pituitary tissue. MenosThe effect of stress-like concentrations of cortisol (C) on the feedback potency of estradiol (E,) was assessed using 32 orchidectomized sheep (wethers) assigned at random to 1 of 4 treatment groups in a 2 x 2 factorial design. Wethers received C (3.6 mg/50 kg per hour; groups 2 and 4) or a comparable volume of C delivery vehicle (groups 1 and 3) as a continuous infusion for 7 days. During the final 48 h of infusion, wethers received E2 (0.3 ug/50 kg/h; groups 3 and 4) or E2 delivery vehicle (groups 1 and 2). The pattern of LH secretion was assessed during a 4 h period of intensive blood collection beginning 44 h after initiation of E2 infusion. Gonadotroph responsiveness (LH secretion induced by GnRH challenge [500 ng, i.v.]) was determined 48 h after E2 delivery was begun. Although lhe frequency of secretory episodes of LH was not affected (p > 0.05) by infusion of C or E2 alone, LH pulse frequency was significantly decreased in wethers receiving C and E2 in combination. In contrast, neither the magnitude of basal gonadotroph responsiveness nor the extent of E2-dependent augmentation of responsiveness was significantly affected by stress-like concentrations of C. In a second experiment, the effect of C on the magnitude of E2-induced in- crease in pituitary concentration of GnRH receptor and GnRH receptor mRNA was assessed using 32 additional wethers. Continuous infusion of E2 for 48 h increased (p < 0.05) tissue concentrations of GnRH receptor and GnRH receptor mRNA. Con- ... Mostrar Tudo |
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Palavras-Chave: |
Gonadotropina. |
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Thesagro: |
Hormônio; Ovino; Stress. |
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Thesaurus Nal: |
cortisol. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02515naa a2200217 a 4500
001 1528806
005 2002-11-06
008 1999 bl uuuu u00u1 u #d
100 1 $aDALEY, C. A.
245 $aEffect of stress-like concentrations of cortisol on gonadotroph function in orchidectomized sheep.
260 $c1999
520 $aThe effect of stress-like concentrations of cortisol (C) on the feedback potency of estradiol (E,) was assessed using 32 orchidectomized sheep (wethers) assigned at random to 1 of 4 treatment groups in a 2 x 2 factorial design. Wethers received C (3.6 mg/50 kg per hour; groups 2 and 4) or a comparable volume of C delivery vehicle (groups 1 and 3) as a continuous infusion for 7 days. During the final 48 h of infusion, wethers received E2 (0.3 ug/50 kg/h; groups 3 and 4) or E2 delivery vehicle (groups 1 and 2). The pattern of LH secretion was assessed during a 4 h period of intensive blood collection beginning 44 h after initiation of E2 infusion. Gonadotroph responsiveness (LH secretion induced by GnRH challenge [500 ng, i.v.]) was determined 48 h after E2 delivery was begun. Although lhe frequency of secretory episodes of LH was not affected (p > 0.05) by infusion of C or E2 alone, LH pulse frequency was significantly decreased in wethers receiving C and E2 in combination. In contrast, neither the magnitude of basal gonadotroph responsiveness nor the extent of E2-dependent augmentation of responsiveness was significantly affected by stress-like concentrations of C. In a second experiment, the effect of C on the magnitude of E2-induced in- crease in pituitary concentration of GnRH receptor and GnRH receptor mRNA was assessed using 32 additional wethers. Continuous infusion of E2 for 48 h increased (p < 0.05) tissue concentrations of GnRH receptor and GnRH receptor mRNA. Con- current delivery of C did not affect (p > 0.05) E2-induced in- crease in GnRH receptor mRNA but significantly reduced the magnitude of the E2-dependent increase in pituitary concentration of GnRH receptor. Collectively, these data indicate that stress-like concentrations of C enhance the negative feedback potency of E2 and reduce estrogen-dependent augmentation of the concentration of GnRH receptor in pituitary tissue.
650 $acortisol
650 $aHormônio
650 $aOvino
650 $aStress
653 $aGonadotropina
700 1 $aSAKURAI, H.
700 1 $aADAMS, B. M.
700 1 $aADAMS, T. E.
773 $tBiology of Reproduction$gv. 60, n. 1, p. 158-163, 1999.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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| Registros recuperados : 7 | |
| 3. |  | VERGARA, L. P.; OLIVEIRA, R. M.; FRANZON, R. C.; CHIM, J. F.; ZAMBIAZI, R. C. Efeito da retenção de compostos bioativos e perfil sensorial em balas mastigáveis formuladas com polpa Blend. Brazilian Journal of Development, Curitiba, v. 6, n. 11, p. 90148-90159, nov. 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 5 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 4. | | VERGARA, L. P.; REISSIG, G. N.; PÔRTO, A. C. S.; LIMA, M. M.; FRANZON, R. C.; CHIM, J. F. Avaliação do potencial de consumo de balas mastigáveis convencional e de baixo valor calórico de araçá amarelo (Psidium cattleianum sabine). In: SIMPÓSIO DE SEGURANÇA ALIMENTAR, 5., 2015, Bento Gonçalves. Alimentação e saúde. Bento Gonçalves: SBCTA-RS, 2015.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 5. | | REISSIG, G. N.; VERGARA, L. P.; LIMA, M. M.; PÔRTO, A. C.; FRANZON, R. C.; CHIM, J. F. Balas mastigáveis de araçá amarelo (PSIDIUM Cattleianum Sabine) convencional e de baixo valor calórico: avaliação físico-química e fitoquímica. In: SIMPÓSIO DE SEGURANÇA ALIMENTAR, 5., 2015, Bento Gonçalves. Alimentação e saúde. Bento Gonçalves: SBCTA-RS, 2015.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 6. | | REISSIG, G. N.; VERGARA, L. P.; LIMA, M. M.; PÔRTO, A. C.; FRANZON, R. C.; CHIM, J. F. Estabilidade físico-química e microbiológica de geleias de araçá vermelho (Psidium cattleianum Sabine) convencional e diet. In: SIMPÓSIO DE SEGURANÇA ALIMENTAR, 5., 2015, Bento Gonçalves. Alimentação e saúde. Bento Gonçalves: SBCTA-RS, 2015.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 7. | | VERGARA, L. P.; REISSIG, G. N.; FRANZON, R. C.; CARVALHO, I. R.; ZAMBIAZI, R. C.; RODRIGUES, R. S.; CHIM, J. F. Stability of bioactive compounds in conventional and low-calorie sweet chewable candies prepared with red and yellow strawberry guava pulps. International Food Research Journal, v. 27, n. 4, p. 625-634, Aug. 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Clima Temperado. |
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| Registros recuperados : 7 | |
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