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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
30/03/2000 |
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Data da última atualização: |
02/10/2023 |
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Autoria: |
HODGSON, A. L. M.; TACHEDJIAN, M.; CORNER, L. A.; RADFORD, A. J. |
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Título: |
Protection of sheep against caseous lymphadenitis by use of a single oral dose of live recombinant Corynebacterium pseudotuberculosis. |
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Ano de publicação: |
1994 |
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Fonte/Imprenta: |
Infection and Immunity, v. 62, n. 12, p. 5275-5280, Dec., 1994. |
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DOI: |
10.1128/iai.62.12.5275-5280.1994 |
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Idioma: |
Inglês |
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Conteúdo: |
An inactive form of the Corynebacterium pseudotuberculosis phospholipase D (PLD) gene was constructed and expressed in a PLD-negative strain (designated Toxminus) of C. pseudotuberculosis. Antibody responses specific to Toxminus and both Toxminus and PLD proteins were detected in sheep following oral administration of Toxminus or Toxminus expressing the PLD toxoid, respectively. However, only those sheep vaccinated with Toxminus expressing PLD toxoid were protected against wild-type challenge. These results confirm the importance of PLD as a protective antigen and demonstrate both the potential for developing an oral caseous lymphadenitis vaccine and C. pseudotuberculosis Toxminus as a live vaccine vector. |
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Palavras-Chave: |
Antibody; Therapeutic use; Vacina oral; Vacina recombinante. |
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Thesagro: |
Corynebacterium Pseudotuberculosis; Linfadenite Caseosa. |
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Thesaurus Nal: |
Bacterial vaccines; Disease control; Disease prevention; Feces; Immunoglobulin G; Immunology; Phospholipase D; Sheep diseases; Synthetic vaccines; Toxoids; Vaccination. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 01851naa a2200373 a 4500
001 1524104
005 2023-10-02
008 1994 bl uuuu u00u1 u #d
024 7 $a10.1128/iai.62.12.5275-5280.1994$2DOI
100 1 $aHODGSON, A. L. M.
245 $aProtection of sheep against caseous lymphadenitis by use of a single oral dose of live recombinant Corynebacterium pseudotuberculosis.$h[electronic resource]
260 $c1994
520 $aAn inactive form of the Corynebacterium pseudotuberculosis phospholipase D (PLD) gene was constructed and expressed in a PLD-negative strain (designated Toxminus) of C. pseudotuberculosis. Antibody responses specific to Toxminus and both Toxminus and PLD proteins were detected in sheep following oral administration of Toxminus or Toxminus expressing the PLD toxoid, respectively. However, only those sheep vaccinated with Toxminus expressing PLD toxoid were protected against wild-type challenge. These results confirm the importance of PLD as a protective antigen and demonstrate both the potential for developing an oral caseous lymphadenitis vaccine and C. pseudotuberculosis Toxminus as a live vaccine vector.
650 $aBacterial vaccines
650 $aDisease control
650 $aDisease prevention
650 $aFeces
650 $aImmunoglobulin G
650 $aImmunology
650 $aPhospholipase D
650 $aSheep diseases
650 $aSynthetic vaccines
650 $aToxoids
650 $aVaccination
650 $aCorynebacterium Pseudotuberculosis
650 $aLinfadenite Caseosa
653 $aAntibody
653 $aTherapeutic use
653 $aVacina oral
653 $aVacina recombinante
700 1 $aTACHEDJIAN, M.
700 1 $aCORNER, L. A.
700 1 $aRADFORD, A. J.
773 $tInfection and Immunity$gv. 62, n. 12, p. 5275-5280, Dec., 1994.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
