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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
09/02/1996 |
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Data da última atualização: |
18/05/2023 |
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Autoria: |
DANTZER, R.; KELLY, K. W. |
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Título: |
Stress and immunity: an integrated view of relationships between the brain and the immune system |
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Ano de publicação: |
1989 |
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Fonte/Imprenta: |
Life Science, v. 44, n. 26, p. 1995-2008, 1989. |
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DOI: |
https://doi.org/10.1016/0024-3205(89)90345-7 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The old notion that stress exacerbates the progression of physical illness via its corticosteroid-mediated immunosuppressive effects must be revised. Experimental and clinical studies demonstrate that both laboratory and natural stressors alter the activities of lymphocytes and macrophages in a complex way that depends on the type of immune response, the physical and psychological characteristics of the stressor and the timing of stress relative to the induction and expression of the immune event. The influences of stress on immunity are mediated not only by glucocorticoids but also by catecholamines, endogenous opioids and pituitary hormones such as growth hormone. Sensitivity of the immune system to stress is not simply fortuitous but is an indirect consequence of the regulatory reciprocal influences that exist between the immune system and the central nervous system. The immune system receives signals from the brain and the neuroendocrine system via the autonomic nervous system and hormones and sends information to the brain via cytokines. These connections appear to be part of a long-loop regulatory feedback system that plays an important role in the coordination of behavioral and physiological responses to infection and inflammation. |
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Palavras-Chave: |
Biological Factors; Estresse; Immune Tolerance; Neurotransmitter Agents; Revisao; Sistema imunologico; Sistema neuroendocrino. |
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Thesaurus Nal: |
Animal stress; Brain; Cytokines; Hormones; Humans; Physiology. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
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001 1523174
005 2023-05-18
008 1989 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/0024-3205(89)90345-7$2DOI
100 1 $aDANTZER, R.
245 $aStress and immunity$ban integrated view of relationships between the brain and the immune system$h[electronic resource]
260 $c1989
520 $aAbstract: The old notion that stress exacerbates the progression of physical illness via its corticosteroid-mediated immunosuppressive effects must be revised. Experimental and clinical studies demonstrate that both laboratory and natural stressors alter the activities of lymphocytes and macrophages in a complex way that depends on the type of immune response, the physical and psychological characteristics of the stressor and the timing of stress relative to the induction and expression of the immune event. The influences of stress on immunity are mediated not only by glucocorticoids but also by catecholamines, endogenous opioids and pituitary hormones such as growth hormone. Sensitivity of the immune system to stress is not simply fortuitous but is an indirect consequence of the regulatory reciprocal influences that exist between the immune system and the central nervous system. The immune system receives signals from the brain and the neuroendocrine system via the autonomic nervous system and hormones and sends information to the brain via cytokines. These connections appear to be part of a long-loop regulatory feedback system that plays an important role in the coordination of behavioral and physiological responses to infection and inflammation.
650 $aAnimal stress
650 $aBrain
650 $aCytokines
650 $aHormones
650 $aHumans
650 $aPhysiology
653 $aBiological Factors
653 $aEstresse
653 $aImmune Tolerance
653 $aNeurotransmitter Agents
653 $aRevisao
653 $aSistema imunologico
653 $aSistema neuroendocrino
700 1 $aKELLY, K. W.
773 $tLife Science$gv. 44, n. 26, p. 1995-2008, 1989.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
