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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
01/08/1992 |
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Data da última atualização: |
27/06/2023 |
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Autoria: |
MJOR-GRIMSRUD, M.; SOLI, N. E.; SIVERTSEN, T. |
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Título: |
The distribution of soluble copper- and zinc-binding proteins in goat liver. |
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Ano de publicação: |
1979 |
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Fonte/Imprenta: |
Acta Pharmacology Toxicology, v. 45, n. 5, p. 319-323, 1979. |
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DOI: |
10.1111/j.1600-0773.1979.tb02337.x. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The distribution of copper and zinc in the soluble proteins from goat liver after gel filtration were determined. Samples from normal slaughtered animals as well as from experimentally copper-loaded goats were tested. The copper- and zinc-binding proteins were mainly separated into 3 different fractions. The approximate molecular weights were greater than 65,000, 35,000 and 10,000. Varying amounts of zinc were eluted in a fourth fraction of molecular weight less than 2000. The results indicate that the distribution of copper and zinc among soluble metal-binding proteins are highly dependent on the total liver zinc concentration. In the majority of samples, with zinc levels within 20 to 45 microgram/g wet weight, the dominating copper- and zinc-binding protein fraction was the high-molecular weight fraction. This did not seem to be influenced by the total liver copper level. In the samples with high total zinc levels (greater than 60 microgram/g w.w.) there was a shift in protein distribution of both metals toward the low-molecular weight fractions. |
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Palavras-Chave: |
Hepatica. |
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Thesagro: |
Bioquímica; Caprino. |
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Thesaurus Nal: |
Biochemical compounds; Copper; Gel chromatography; Goats; Liver; Metabolism; Molecular weight; Protein binding; Zinc. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 01906naa a2200301 a 4500
001 1522008
005 2023-06-27
008 1979 bl uuuu u00u1 u #d
024 7 $a10.1111/j.1600-0773.1979.tb02337.x.$2DOI
100 1 $aMJOR-GRIMSRUD, M.
245 $aThe distribution of soluble copper- and zinc-binding proteins in goat liver.$h[electronic resource]
260 $c1979
520 $aAbstract: The distribution of copper and zinc in the soluble proteins from goat liver after gel filtration were determined. Samples from normal slaughtered animals as well as from experimentally copper-loaded goats were tested. The copper- and zinc-binding proteins were mainly separated into 3 different fractions. The approximate molecular weights were greater than 65,000, 35,000 and 10,000. Varying amounts of zinc were eluted in a fourth fraction of molecular weight less than 2000. The results indicate that the distribution of copper and zinc among soluble metal-binding proteins are highly dependent on the total liver zinc concentration. In the majority of samples, with zinc levels within 20 to 45 microgram/g wet weight, the dominating copper- and zinc-binding protein fraction was the high-molecular weight fraction. This did not seem to be influenced by the total liver copper level. In the samples with high total zinc levels (greater than 60 microgram/g w.w.) there was a shift in protein distribution of both metals toward the low-molecular weight fractions.
650 $aBiochemical compounds
650 $aCopper
650 $aGel chromatography
650 $aGoats
650 $aLiver
650 $aMetabolism
650 $aMolecular weight
650 $aProtein binding
650 $aZinc
650 $aBioquímica
650 $aCaprino
653 $aHepatica
700 1 $aSOLI, N. E.
700 1 $aSIVERTSEN, T.
773 $tActa Pharmacology Toxicology$gv. 45, n. 5, p. 319-323, 1979.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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