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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
01/08/1992 |
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Data da última atualização: |
21/06/2023 |
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Autoria: |
SILMAN, R. E.; HOLLAND, D.; CHARD, T.; LOWRY, P. J.; HOPE, J.; REES, L. H.; THOMAS, A.; NATHANIELSZ, P. |
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Título: |
Adrenocorticotrophin-related peptides in adult and foetal sheep pituitary glands. |
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Ano de publicação: |
1979 |
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Fonte/Imprenta: |
Journal Endocrinology, v. 81, n. 1, p. 19-34, 1979. |
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DOI: |
10.1677/joe.0.0810019. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Differences in foetal and adult adrenal function may be due to qualitative as well as quantitative changes in the pituitary corticotrophic stimulus. Pituitary glands from adult and foetal sheep were freshly dissected and stored at -70 degrees C until extracted at pH 1.5. The extracts were subjected to chromatography on Sephadex G-100 superfine and fractions were assayed by multiple radioimmunoassays directed against the NH2- and CO2H-terminal sequences of ACTH and lipotrophin (LPH). Peaks corresponding to beta-melanocyte-stimulating hormone (beta-MSH), beta-LHP, gamma-LPH, beta-endorphin and ACTH were identified, with little or no evidence for the presence of alpha-MSH and corticotrophin-like intermediate lobe peptide. Three peaks of large molecular weight material, A. B and C, were identified and their relative proportions shown to be considerably greater in the foetus than in the adult. The immunoassay profile of peaks A and B suggested that they were 'stem hormones' which could give rise to a family of biologically active peptides. Since the 'family tree' which they engender varies according to the stage of development, it is proposed that the changes in the 'trophic family' may explain the different adrenal responses of the foetal and adult sheep. |
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Palavras-Chave: |
Adrenocorticotropic Hormone; Endocrinologia Fisiologia. |
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Thesagro: |
Ovino; Reprodução. |
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Thesaurus Nal: |
Amino acid sequences; Endocrinology; Gel chromatography; Melanocyte-stimulating hormone; Metabolism; Molecular weight; Peptides; Pituitary gland; Pregnancy; Radioimmunoassays; Reproduction; Sheep. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02413naa a2200409 a 4500
001 1521186
005 2023-06-21
008 1979 bl uuuu u00u1 u #d
024 7 $a10.1677/joe.0.0810019.$2DOI
100 1 $aSILMAN, R. E.
245 $aAdrenocorticotrophin-related peptides in adult and foetal sheep pituitary glands.$h[electronic resource]
260 $c1979
520 $aAbstract: Differences in foetal and adult adrenal function may be due to qualitative as well as quantitative changes in the pituitary corticotrophic stimulus. Pituitary glands from adult and foetal sheep were freshly dissected and stored at -70 degrees C until extracted at pH 1.5. The extracts were subjected to chromatography on Sephadex G-100 superfine and fractions were assayed by multiple radioimmunoassays directed against the NH2- and CO2H-terminal sequences of ACTH and lipotrophin (LPH). Peaks corresponding to beta-melanocyte-stimulating hormone (beta-MSH), beta-LHP, gamma-LPH, beta-endorphin and ACTH were identified, with little or no evidence for the presence of alpha-MSH and corticotrophin-like intermediate lobe peptide. Three peaks of large molecular weight material, A. B and C, were identified and their relative proportions shown to be considerably greater in the foetus than in the adult. The immunoassay profile of peaks A and B suggested that they were 'stem hormones' which could give rise to a family of biologically active peptides. Since the 'family tree' which they engender varies according to the stage of development, it is proposed that the changes in the 'trophic family' may explain the different adrenal responses of the foetal and adult sheep.
650 $aAmino acid sequences
650 $aEndocrinology
650 $aGel chromatography
650 $aMelanocyte-stimulating hormone
650 $aMetabolism
650 $aMolecular weight
650 $aPeptides
650 $aPituitary gland
650 $aPregnancy
650 $aRadioimmunoassays
650 $aReproduction
650 $aSheep
650 $aOvino
650 $aReprodução
653 $aAdrenocorticotropic Hormone
653 $aEndocrinologia Fisiologia
700 1 $aHOLLAND, D.
700 1 $aCHARD, T.
700 1 $aLOWRY, P. J.
700 1 $aHOPE, J.
700 1 $aREES, L. H.
700 1 $aTHOMAS, A.
700 1 $aNATHANIELSZ, P.
773 $tJournal Endocrinology$gv. 81, n. 1, p. 19-34, 1979.
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