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Registro Completo |
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Biblioteca(s): |
Embrapa Soja. |
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Data corrente: |
04/03/2008 |
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Data da última atualização: |
05/08/2017 |
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Autoria: |
ABDELNOOR, R. V.; YULE, R.; ELO, A.; CHRISTENSEN, A. C.; MEYER-GAUEN, G.; MACKENZIE, S. A. |
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Título: |
Substoichiometric shifting in the plant mitochondrial genome is influenced by a gene homologous to MutS. |
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Ano de publicação: |
2003 |
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Fonte/Imprenta: |
PNAS, v. 100, n. 10, p. 5968-5973, May 2003. |
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Idioma: |
Inglês |
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Conteúdo: |
The plant mitochondrial genome is retained in a multipartite structure that arises by a process of repeat-mediated homologous recombination. Low-frequency ectopic recombination also occurs, often producing sequence chimeras, aberrant ORFs, and novel subgenomic DNA molecules. This genomic plasticity may distinguish the plant mitochondrion from mammalian and fungal types. In plants, relative copy number of recombination-derived subgenomic DNA molecules within mitochondria is controlled by nuclear genes, and a genomic shifting process can result in their differential copy number suppression to nearly undetectable levels. We have cloned a nuclear gene that regulates mitochondrial substoichiometric shifting in Arabidopsis. The CHM gene was shown to encode a protein related to the MutS protein of Escherichia coli that is involved in mismatch repair and DNA recombination. We postulate that the process of substoichiometric shifting in plants may be a consequence of ectopic recombination suppression or replication stalling at ectopic recombination sites to effect molecule-specific copy number modulation. |
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Thesagro: |
Genética. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01663naa a2200193 a 4500
001 1467176
005 2017-08-05
008 2003 bl --- 0-- u #d
100 1 $aABDELNOOR, R. V.
245 $aSubstoichiometric shifting in the plant mitochondrial genome is influenced by a gene homologous to MutS.
260 $c2003
520 $aThe plant mitochondrial genome is retained in a multipartite structure that arises by a process of repeat-mediated homologous recombination. Low-frequency ectopic recombination also occurs, often producing sequence chimeras, aberrant ORFs, and novel subgenomic DNA molecules. This genomic plasticity may distinguish the plant mitochondrion from mammalian and fungal types. In plants, relative copy number of recombination-derived subgenomic DNA molecules within mitochondria is controlled by nuclear genes, and a genomic shifting process can result in their differential copy number suppression to nearly undetectable levels. We have cloned a nuclear gene that regulates mitochondrial substoichiometric shifting in Arabidopsis. The CHM gene was shown to encode a protein related to the MutS protein of Escherichia coli that is involved in mismatch repair and DNA recombination. We postulate that the process of substoichiometric shifting in plants may be a consequence of ectopic recombination suppression or replication stalling at ectopic recombination sites to effect molecule-specific copy number modulation.
650 $aGenética
700 1 $aYULE, R.
700 1 $aELO, A.
700 1 $aCHRISTENSEN, A. C.
700 1 $aMEYER-GAUEN, G.
700 1 $aMACKENZIE, S. A.
773 $tPNAS$gv. 100, n. 10, p. 5968-5973, May 2003.
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Embrapa Soja (CNPSO) |
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| 1. |  | ABDELNOOR, R. V.; YULE, R.; ELO, A.; CHRISTENSEN, A. C.; MEYER-GAUEN, G.; MACKENZIE, S. A. Substoichiometric shifting in the plant mitochondrial genome is influenced by a gene homologous to MutS. PNAS, v. 100, n. 10, p. 5968-5973, May 2003.| Biblioteca(s): Embrapa Soja. |
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