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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
20/08/2009 |
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Data da última atualização: |
15/01/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CASTRO, A. de; FRONZA, C. F.; ALVES, D. |
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Afiliação: |
ALEXANDRE DE CASTRO, CNPTIA, UNIFESP; CARLOS FREDERICO FRONZA, UNIFESP; DOMINGOS ALVES, UNIFESP, FMRP/USP. |
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Título: |
A dynamical modeling to study the adaptive immune system and the influence of antibodies in the immune memory. |
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Ano de publicação: |
2009 |
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Fonte/Imprenta: |
Computer Modeling in Engineering & Sciences, Duluth, v. 45, n. 1, p. 83-96, 2009. |
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Idioma: |
Inglês |
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Notas: |
CMES 2009. |
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Conteúdo: |
Immunological systems have been an abundant inspiration to contemporary computer scientists. Problem solving strategies, stemming from known immune system phenomena, have been successfully applied to chall enging problems of modern computing. Simulation systems and mathematical modeling are also beginning use to answer more complex immunological questions as immune memory process and duration of vaccines, where the regulation mechanisms are not still known sufficiently (Lundegaard, Lund, Kesmir, Brunak, Nielsen, 2007). In this article we studied in machina a approach to simulate the process of antigenic mutation and its implications for the process of memory. Our results have suggested that the durability of the immune memory is affected by the process of antigenic mutation.and by populations of soluble antibodies in the blood. The results also strongly suggest that the decrease of the production of antibodies favors the global maintenance of immune memory. |
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Palavras-Chave: |
Anticorpos; Células B; Memória imunológica; Modelo computacional; Modelo dinâmico; Mutação antigênica; Sistema imunológico adaptativo. |
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Thesagro: |
Imunização; Simulação. |
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Thesaurus Nal: |
Immunologic memory; Models. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
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001 1257028
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008 2009 bl uuuu u00u1 u #d
100 1 $aCASTRO, A. de
245 $aA dynamical modeling to study the adaptive immune system and the influence of antibodies in the immune memory.$h[electronic resource]
260 $c2009
500 $aCMES 2009.
520 $aImmunological systems have been an abundant inspiration to contemporary computer scientists. Problem solving strategies, stemming from known immune system phenomena, have been successfully applied to chall enging problems of modern computing. Simulation systems and mathematical modeling are also beginning use to answer more complex immunological questions as immune memory process and duration of vaccines, where the regulation mechanisms are not still known sufficiently (Lundegaard, Lund, Kesmir, Brunak, Nielsen, 2007). In this article we studied in machina a approach to simulate the process of antigenic mutation and its implications for the process of memory. Our results have suggested that the durability of the immune memory is affected by the process of antigenic mutation.and by populations of soluble antibodies in the blood. The results also strongly suggest that the decrease of the production of antibodies favors the global maintenance of immune memory.
650 $aImmunologic memory
650 $aModels
650 $aImunização
650 $aSimulação
653 $aAnticorpos
653 $aCélulas B
653 $aMemória imunológica
653 $aModelo computacional
653 $aModelo dinâmico
653 $aMutação antigênica
653 $aSistema imunológico adaptativo
700 1 $aFRONZA, C. F.
700 1 $aALVES, D.
773 $tComputer Modeling in Engineering & Sciences, Duluth$gv. 45, n. 1, p. 83-96, 2009.
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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