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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
06/11/2025 |
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Data da última atualização: |
10/11/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CARDOSO, T. F.; BRUSCADIN, J. J.; AFONSO, J.; CONTEVILLE, L. C.; ANDRADE, B. G. N.; MALHEIROS, J. M.; FERNANDES, A. C.; DINIZ, W. J. S.; BANERJEE, P.; OLIVEIRA, P. S. N. de; ZERLOTINI NETO, A.; MOURÃO, G. B.; COUTINHO, L. L.; REGITANO, L. C. de A. |
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Afiliação: |
TAINÃ FIGUEIREDO CARDOSO; JENNIFER JESSICA BRUSCADIN, UNIVERSIDADE FEDERAL DE SAO CARLOS; JULIANA AFONSO; LILIANE COSTA CONTEVILLE; BRUNO GABRIEL NASCIMENTO ANDRADE, MUNSTER TECHNOLOGICAL UNIVERSITY; JESSICA MORAES MALHEIROS; ANNA CAROLINA FERNANDES, UNIVERSIDADE DE SÃO PAULO; WELLISON J. S. DINIZ, AUBURN UNIVERSITY; PRIYANKA BANERJEE, AUBURN UNIVERSITY; PRISCILA S. N. DE OLIVEIRA, UNIVERSIDADE FEDERAL DE SAO CARLOS; ADHEMAR ZERLOTINI NETO, CNPTIA; GERSON BARRETO MOURÃO, UNIVERSIDADE DE SÃO PAULO; LUIZ LEHMANN COUTINHO, UNIVERSIDADE DE SÃO PAULO; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Exploring genome, transcriptome, and microbiome interactions related to feed efficiency and methane emissions in Bos indicus through multi-omics network analysis. |
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Ano de publicação: |
2025 |
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Fonte/Imprenta: |
Mammalian Genome, v 36, p. 1153–1172, 2025. |
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DOI: |
https://doi.org/10.1007/s00335-025-10160-w |
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Idioma: |
Inglês |
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Notas: |
Na publicação: Adhemar Zerlotini. |
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Conteúdo: |
The minor effects of many SNP interactions often determine complex traits. This interaction, known as epistasis, represents a non-additive genetic effect in which the influence of one variant depends on the presence of others. In this study, we tested for epistatic effects on the residual feed intake (RFI) and residual methane emission (RME) traits of Nelore cattle. Additionally, we evaluated the impact of these interactions in other omics layers (i.e., microorganism profiles in the rumen content and feces and mRNA and miRNA expression in the rumen wall). The genomic interaction modules identified 14 and 10 significant SNP-SNP modules associated with RME and RFI traits, respectively. The majority of these SNPs were located in intronic and intergenic regions. The top pathways and processes associated with the SNP-SNP modules were identified, with several pathways related to the immune system and actin cytoskeleton organization. Furthermore, many other omics data were correlated with these SNP-SNP modules. Our findings suggest that the immune response and cilium organization may play important roles in feed efficiency. These insights not only provide novel candidates for enhancing these traits through microbiota composition and transcriptional regulation but also underscore the power of network analysis in uncovering new functional interactions. This research provides new insights and highlights candidate features for improving cattle feed efficiency and methane emissions. |
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Palavras-Chave: |
Emissão de metano; Epistatic interactions; Estudo de associação genômica ampla; Genetic interaction; Genome-wide association studies; Interações epistáticas; Polimorfismo de nucleotídeo único. |
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Thesagro: |
Gado Nelore. |
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Thesaurus Nal: |
Beef cattle; Epistasis; Genomics; Nutrigenomics; Quantitative trait loci; Quantitative traits. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 03015naa a2200469 a 4500
001 2181209
005 2025-11-10
008 2025 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s00335-025-10160-w$2DOI
100 1 $aCARDOSO, T. F.
245 $aExploring genome, transcriptome, and microbiome interactions related to feed efficiency and methane emissions in Bos indicus through multi-omics network analysis.$h[electronic resource]
260 $c2025
500 $aNa publicação: Adhemar Zerlotini.
520 $aThe minor effects of many SNP interactions often determine complex traits. This interaction, known as epistasis, represents a non-additive genetic effect in which the influence of one variant depends on the presence of others. In this study, we tested for epistatic effects on the residual feed intake (RFI) and residual methane emission (RME) traits of Nelore cattle. Additionally, we evaluated the impact of these interactions in other omics layers (i.e., microorganism profiles in the rumen content and feces and mRNA and miRNA expression in the rumen wall). The genomic interaction modules identified 14 and 10 significant SNP-SNP modules associated with RME and RFI traits, respectively. The majority of these SNPs were located in intronic and intergenic regions. The top pathways and processes associated with the SNP-SNP modules were identified, with several pathways related to the immune system and actin cytoskeleton organization. Furthermore, many other omics data were correlated with these SNP-SNP modules. Our findings suggest that the immune response and cilium organization may play important roles in feed efficiency. These insights not only provide novel candidates for enhancing these traits through microbiota composition and transcriptional regulation but also underscore the power of network analysis in uncovering new functional interactions. This research provides new insights and highlights candidate features for improving cattle feed efficiency and methane emissions.
650 $aBeef cattle
650 $aEpistasis
650 $aGenomics
650 $aNutrigenomics
650 $aQuantitative trait loci
650 $aQuantitative traits
650 $aGado Nelore
653 $aEmissão de metano
653 $aEpistatic interactions
653 $aEstudo de associação genômica ampla
653 $aGenetic interaction
653 $aGenome-wide association studies
653 $aInterações epistáticas
653 $aPolimorfismo de nucleotídeo único
700 1 $aBRUSCADIN, J. J.
700 1 $aAFONSO, J.
700 1 $aCONTEVILLE, L. C.
700 1 $aANDRADE, B. G. N.
700 1 $aMALHEIROS, J. M.
700 1 $aFERNANDES, A. C.
700 1 $aDINIZ, W. J. S.
700 1 $aBANERJEE, P.
700 1 $aOLIVEIRA, P. S. N. de
700 1 $aZERLOTINI NETO, A.
700 1 $aMOURÃO, G. B.
700 1 $aCOUTINHO, L. L.
700 1 $aREGITANO, L. C. de A.
773 $tMammalian Genome, v 36, p. 1153–1172, 2025.
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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