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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
24/09/2025 |
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Data da última atualização: |
24/09/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SCRAMIN, J. A.; CORREA, T. A.; NONAKA, K. O.; BERNARDES FILHO, R.; FERREIRA, E. J.; LAROCCA, N. M.; BIFFE, B. G.; WANG, C. C.; FORATO, L. A. |
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Afiliação: |
UNIVERSIDADE FEDERAL DE SÃO CARLOS; UNIVERSIDADE FEDERAL DE SÃO CARLOS; UNIVERSIDADE FEDERAL DE SÃO CARLOS; EDNALDO JOSE FERREIRA, CNPDIA; UNIVERSIDADE FEDERAL DE SÃO CARLOS; UNIVERSIDADE FEDERAL DE SÃO CARLOS; UNIVERSIDADE FEDERAL DE SÃO CARLOS; LUCIMARA APARECIDA FORATO, CNPDIA. |
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Título: |
In Vivo Toxicity of Kafirin-Based Coatings with Chitosan Nanoparticles. |
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Ano de publicação: |
2025 |
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Fonte/Imprenta: |
BioNanoScience, v. 15, 499, 2025. |
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Páginas: |
11 p. |
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DOI: |
https://doi.org/10.1007/s12668-025-02127-7 |
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Idioma: |
Inglês |
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Conteúdo: |
The global demand for fresh, healthy agricultural products calls for effective methods to extend shelf life, such as edible coatings. Kafirin, a hydrophobic prolamin from sorghum, can be extracted as a byproduct of ethanol production from sweet sorghum grains. Its barrier effect properties can be enhanced with chitosan nanoparticles (CSNP), which offer antimicrobial and antioxidant effects. However, the formulation, characterization, and in vivo safety of kafirin-CSNP coatings remain underexplored. This study presents the formulation and characterization of a kafirin-CSNP coating, followed by a 5-week safety evaluation in male Wistar rats. Animals were randomly assigned to receive either uncoated bran-based feed (control group) or bran feed coated with the kafirin-CSNP dispersion (experimental group). The process yielded stable nanoparticles with a high zeta potential (77 mV), suggesting good antimicrobial potential. In vivo analyses revealed no significant differences between groups in organ and bone mass, blood biochemical markers, bone quality (densitometry and microtomography), feed intake, or feces excretion. Significant differences were observed in water intake (lower in the experimental group for 3 weeks), creatinine levels (lower in the experimental group), and body weight (lower throughout the study), the latter possibly due to a mild anti-obesity effect of CSNP. These findings support the physiological safety of kafirin-CSNP coatings in an animal model and highlight their potential for future applications in edible coatings for agricultural products intended for human consumption MenosThe global demand for fresh, healthy agricultural products calls for effective methods to extend shelf life, such as edible coatings. Kafirin, a hydrophobic prolamin from sorghum, can be extracted as a byproduct of ethanol production from sweet sorghum grains. Its barrier effect properties can be enhanced with chitosan nanoparticles (CSNP), which offer antimicrobial and antioxidant effects. However, the formulation, characterization, and in vivo safety of kafirin-CSNP coatings remain underexplored. This study presents the formulation and characterization of a kafirin-CSNP coating, followed by a 5-week safety evaluation in male Wistar rats. Animals were randomly assigned to receive either uncoated bran-based feed (control group) or bran feed coated with the kafirin-CSNP dispersion (experimental group). The process yielded stable nanoparticles with a high zeta potential (77 mV), suggesting good antimicrobial potential. In vivo analyses revealed no significant differences between groups in organ and bone mass, blood biochemical markers, bone quality (densitometry and microtomography), feed intake, or feces excretion. Significant differences were observed in water intake (lower in the experimental group for 3 weeks), creatinine levels (lower in the experimental group), and body weight (lower throughout the study), the latter possibly due to a mild anti-obesity effect of CSNP. These findings support the physiological safety of kafirin-CSNP coatings in an animal model and highligh... Mostrar Tudo |
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Palavras-Chave: |
Kafirin; Nanoparticle; Prolamin. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02378naa a2200277 a 4500
001 2179083
005 2025-09-24
008 2025 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s12668-025-02127-7$2DOI
100 1 $aSCRAMIN, J. A.
245 $aIn Vivo Toxicity of Kafirin-Based Coatings with Chitosan Nanoparticles.$h[electronic resource]
260 $c2025
300 $a11 p.
520 $aThe global demand for fresh, healthy agricultural products calls for effective methods to extend shelf life, such as edible coatings. Kafirin, a hydrophobic prolamin from sorghum, can be extracted as a byproduct of ethanol production from sweet sorghum grains. Its barrier effect properties can be enhanced with chitosan nanoparticles (CSNP), which offer antimicrobial and antioxidant effects. However, the formulation, characterization, and in vivo safety of kafirin-CSNP coatings remain underexplored. This study presents the formulation and characterization of a kafirin-CSNP coating, followed by a 5-week safety evaluation in male Wistar rats. Animals were randomly assigned to receive either uncoated bran-based feed (control group) or bran feed coated with the kafirin-CSNP dispersion (experimental group). The process yielded stable nanoparticles with a high zeta potential (77 mV), suggesting good antimicrobial potential. In vivo analyses revealed no significant differences between groups in organ and bone mass, blood biochemical markers, bone quality (densitometry and microtomography), feed intake, or feces excretion. Significant differences were observed in water intake (lower in the experimental group for 3 weeks), creatinine levels (lower in the experimental group), and body weight (lower throughout the study), the latter possibly due to a mild anti-obesity effect of CSNP. These findings support the physiological safety of kafirin-CSNP coatings in an animal model and highlight their potential for future applications in edible coatings for agricultural products intended for human consumption
653 $aKafirin
653 $aNanoparticle
653 $aProlamin
700 1 $aCORREA, T. A.
700 1 $aNONAKA, K. O.
700 1 $aBERNARDES FILHO, R.
700 1 $aFERREIRA, E. J.
700 1 $aLAROCCA, N. M.
700 1 $aBIFFE, B. G.
700 1 $aWANG, C. C.
700 1 $aFORATO, L. A.
773 $tBioNanoScience$gv. 15, 499, 2025.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
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| Registros recuperados : 4 | |
| 1. |  | BITTENCOURT, P.; TANIGUTTI, L.; MONTEIRO-VITORELLO, C.; LEITE, S.; ARBEX, W. A.; ALMEIDA, F. Building LeifDB: a database for storing information about genome comparative analysis of the Leifsonia xyli. In: INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 11., 2015, São Paulo. Proceedings... São Paulo: Universidade de São Paulo, 2015. p. 152. X-Meeting 2015.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 3. | | PRADO, G. S.; ROCHA, D. C.; SANTOS, L. N. dos; CONTILIANI, D. F.; NOBILE, P. M.; MARTINATI-SCHENK, J. C.; PADILHA, L.; MALUF, M. P.; LUBINI, G.; PEREIRA, T. C.; MONTEIRO-VITORELLO, C. B.; CRESTE, S.; BOSCARIOL-CAMARGO, R. L.; TAKITA, M. A.; CRISTOFANI-YALY, M.; SOUZA, A. A. de. CRISPR technology towards genome editing of the perennial and semi-perennial crops citrus, coffee and sugarcane. Frontiers in Plant Science, v. 14, article 1331258, 2023.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Café. |
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| 4. | | VIEIRA, L. G. E.; ANDRADE, A. C.; COLOMBO, C. A.; MORAES, A. H. de A.; METHA, A.; OLIVEIRA, A. C. de; LABATE, C. A.; MARINO, C. L.; MONTEIRO-VITORELLO, C. de B.; MONTE, D. C.; GIGLIOTI, E.; KIMURA, E. T.; ROMANO, E.; KURAMAE, E. E.; LEMOS, E. G. M.; ALMEIDA, E. R. P. de; JORGE, E. C.; ALBUQUERQUE, E. V. S.; SILVA, F. R. da; VINECKY, F.; SAWAZAKI, H. E.; DORRY, H. F. A.; CARRER, H.; ABREU, I. N.; BATISTA, J. A. N.; TEIXEIRA, J. B.; KITAJIMA, J. P.; XAVIER, K. G.; LIMA, L. M. de; CAMARGO, L. E. A. de; PEREIRA, L. F. P.; COUTINHO, L. L.; LEMOS, M. V. F.; ROMANO, M. R.; MACHADO, M. A.; COSTA, M. M. do C.; SA, M. F. G. de; GOLDMAN, M. H. S.; FERRO, M. I. T.; TINOCO, M. L. P.; OLIVEIRA, M. C.; VAN SLUYS, M-A.; SHIMIZU, M. M.; MALUF, M. P.; EIRA, M. T. S. da; GUERREIRO FILHO, O.; ARRUDA, P.; MAZZAFERA, P.; MARIANI, P. D. S. C.; OLIVEIRA, R. L. B. C. de; HARAKAVA, R.; BALBAO, S. F.; TSAI, S. M.; MAURO, S. M. Z. di; SANTOS, S. N.; SIQUEIRA, W. J.; COSTA, G. G. L.; FORMIGHIERI, E. F.; CARAZZOLLE, M. F.; PEREIRA, G. A. G. Brazilian coffee genome project: an EST-based genomic resource. Brazilian Journal of Plant Physiology, v. 18, n. 1, p. 95-108, 2006.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: -- - A |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| Registros recuperados : 4 | |
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