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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agroindústria Tropical. Para informações adicionais entre em contato com cnpat.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria Tropical. |
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Data corrente: |
17/07/2025 |
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Data da última atualização: |
17/07/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SOUZA, F. F. P. DE; MORAES SEGUNDO, J. DE. D. P. DE M.; CONSTANTINO, J. S. F.; LOREVICE, M. V.; BEPPU, M. M.; MATTOS, A. L. A.; ANDRADE, F. K. |
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Afiliação: |
FRANCISCO FÁBIO PEREIRA DE SOUZA; JOÃO DE DEUS PEREIRA DE MORAES MORAES SEGUNDO ; JAMILLY SALUSTIANO FERREIRA CONSTANTINO ; MARCOS VINICIUS LOREVICE; MARISA MASUMI BEPPU , UNIVERSITY OF CAMPINAS; ADRIANO LINCOLN ALBUQUERQUE MATTOS, CNPAT; FÁBIA KARINE ANDRADE. |
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Título: |
A graphene/silver‑PCL/PVP‑based nanocomposite membrane produced by electrospinning provides protection against coronavirus and pathogenic bacteria. |
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Ano de publicação: |
2025 |
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Fonte/Imprenta: |
Polymer Bulletin, 2025. |
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DOI: |
https://doi.org/10.1007/s00289-025-05920-2 |
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Idioma: |
Inglês |
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Conteúdo: |
The spread of infectious diseases through air and contaminated surfaces is a constant threat to public health. The development of porous materials based on nanofibers incorporated with antimicrobial compounds results in the production of multifunctional composites that may control the spread of infectious agents. This study aimed to develop and characterize nanofibers incorporated with graphene oxide and silver nanoparticles (GOAg), produced by electrospinning. The GOAg nanocomposite was synthesized and incorporated into a poly(ε-caprolactone) and (PCL)/polyvinylpyrrolidone (PVP) (1:1) blend solution and used to produce nanofibers. Transmission electron microscopy (TEM) and Raman spectroscopy initially confirmed that the GOAg nanocomposite exhibited silver nanoparticles (diameter, 10.4 ± 4.0 nm) anchored onto GO sheets. The GOAg-PCL/PVP nanofibers were characterized in terms of morphological, chemical, thermal, and mechanical features and their biological activities against bacteria and MHV-3 coronavirus. The GOAg-PCL/PVP nanofiber presented a porous structure, with a diameter of 0.52 ± 0.38 µm, and improved thermal and mechanical properties. Furthermore, the GOAg-PCL/PVP nanofiber inactivated 99.97% coronavirus, inhibited the growth of S. aureus (98%), E. coli (62%), and P. aeruginosa (48%) bacteria, and was not cytotoxic to fibroblasts. The GOAg-PCL/PVP nanofiber exhibits significant hysicochemical properties and antimicrobial properties, making it ideal for the development of a multifunctional nanocomposite for health applications. These materials are particularly suitable for advanced filters for air filtration and purification, especially for use in personal protective equipment used during viral outbreaks or pandemics. MenosThe spread of infectious diseases through air and contaminated surfaces is a constant threat to public health. The development of porous materials based on nanofibers incorporated with antimicrobial compounds results in the production of multifunctional composites that may control the spread of infectious agents. This study aimed to develop and characterize nanofibers incorporated with graphene oxide and silver nanoparticles (GOAg), produced by electrospinning. The GOAg nanocomposite was synthesized and incorporated into a poly(ε-caprolactone) and (PCL)/polyvinylpyrrolidone (PVP) (1:1) blend solution and used to produce nanofibers. Transmission electron microscopy (TEM) and Raman spectroscopy initially confirmed that the GOAg nanocomposite exhibited silver nanoparticles (diameter, 10.4 ± 4.0 nm) anchored onto GO sheets. The GOAg-PCL/PVP nanofibers were characterized in terms of morphological, chemical, thermal, and mechanical features and their biological activities against bacteria and MHV-3 coronavirus. The GOAg-PCL/PVP nanofiber presented a porous structure, with a diameter of 0.52 ± 0.38 µm, and improved thermal and mechanical properties. Furthermore, the GOAg-PCL/PVP nanofiber inactivated 99.97% coronavirus, inhibited the growth of S. aureus (98%), E. coli (62%), and P. aeruginosa (48%) bacteria, and was not cytotoxic to fibroblasts. The GOAg-PCL/PVP nanofiber exhibits significant hysicochemical properties and antimicrobial properties, making it ideal for the developme... Mostrar Tudo |
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Palavras-Chave: |
Coronavirus; COVID-19; Electrospinning; Virucidal nanocomposite. |
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Categoria do assunto: |
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Marc: |
LEADER 02593naa a2200253 a 4500
001 2177381
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024 7 $ahttps://doi.org/10.1007/s00289-025-05920-2$2DOI
100 1 $aSOUZA, F. F. P. DE
245 $aA graphene/silver‑PCL/PVP‑based nanocomposite membrane produced by electrospinning provides protection against coronavirus and pathogenic bacteria.$h[electronic resource]
260 $c2025
520 $aThe spread of infectious diseases through air and contaminated surfaces is a constant threat to public health. The development of porous materials based on nanofibers incorporated with antimicrobial compounds results in the production of multifunctional composites that may control the spread of infectious agents. This study aimed to develop and characterize nanofibers incorporated with graphene oxide and silver nanoparticles (GOAg), produced by electrospinning. The GOAg nanocomposite was synthesized and incorporated into a poly(ε-caprolactone) and (PCL)/polyvinylpyrrolidone (PVP) (1:1) blend solution and used to produce nanofibers. Transmission electron microscopy (TEM) and Raman spectroscopy initially confirmed that the GOAg nanocomposite exhibited silver nanoparticles (diameter, 10.4 ± 4.0 nm) anchored onto GO sheets. The GOAg-PCL/PVP nanofibers were characterized in terms of morphological, chemical, thermal, and mechanical features and their biological activities against bacteria and MHV-3 coronavirus. The GOAg-PCL/PVP nanofiber presented a porous structure, with a diameter of 0.52 ± 0.38 µm, and improved thermal and mechanical properties. Furthermore, the GOAg-PCL/PVP nanofiber inactivated 99.97% coronavirus, inhibited the growth of S. aureus (98%), E. coli (62%), and P. aeruginosa (48%) bacteria, and was not cytotoxic to fibroblasts. The GOAg-PCL/PVP nanofiber exhibits significant hysicochemical properties and antimicrobial properties, making it ideal for the development of a multifunctional nanocomposite for health applications. These materials are particularly suitable for advanced filters for air filtration and purification, especially for use in personal protective equipment used during viral outbreaks or pandemics.
653 $aCoronavirus
653 $aCOVID-19
653 $aElectrospinning
653 $aVirucidal nanocomposite
700 1 $aMORAES SEGUNDO, J. DE. D. P. DE M.
700 1 $aCONSTANTINO, J. S. F.
700 1 $aLOREVICE, M. V.
700 1 $aBEPPU, M. M.
700 1 $aMATTOS, A. L. A.
700 1 $aANDRADE, F. K.
773 $tPolymer Bulletin, 2025.
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| 1. |  | SANTOS, H. F.; ALMEIDA, S. R.; GIL, L. H. V. G.; HOTT-NETO, J.; TREVISOL, I. M.; BRENTANO, L.; BERTANI, G. R. Investigação de um caso de suspeita clínica de doença imunossupressora em Gallus gallus na região Nordeste do Brasil. In: WORKSHOP INTERNACIONAL EM BIOTECNOLOGIA, 1.; ENCONTRO ALFA-VALNATURA, 3.; JORNADA CIENTÍFICA DO LIKA, 3., 2008, Recife. Anais. Recife: Ed. Universitária da UFPE, 2008. p. 323-324. Projeto/Plano de Ação: 16.00.30.004.00.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
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