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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Alimentos e Territórios; Embrapa Soja. |
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Data corrente: |
26/07/2024 |
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Data da última atualização: |
26/07/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SILVA, M. F. S.; SILVA, L. M. A. e; QUINTELA, A. L.; SILVA, F. A. N.; OLIVEIRA, F. DE C. E. DE; LUCIANO, M. C. DOS S.; RODRIGUES, T. H. S.; ALEXANDRE FILHO, E. G.; BRITO, E. S. de; CANUTO, K. M.; PESSOA, C.; ZOCOLO, G. J. |
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Afiliação: |
MARIA FRANCILENE S. SILVA, UNIVERSIDADE FEDERAL DO CEARÁ; LORENA MARA ALEXANDRE E SILVA, CNPAT; AMANDA L. QUINTELA, UNIVERSIDADE FEDERAL DO CEARÁ; FRANCISCA ALINY N. SILVA, UNIVERSIDADE FEDERAL DO CEARÁ; FÁTIMA DE CÁSSIA E. DE OLIVEIRA, UNIVERSIDADE FEDERAL DO CEARÁ; MARIA CLAUDIA DOS S. LUCIANO, UNIVERSIDADE FEDERAL DO CEARÁ; TIGRESSA HELENA S. RODRIGUES, UNIVERSIDADE ESTADUAL VALE DO ACARAÚ, SOBRAL; ELENILSON GODOY A. FILHO, UNIVERSIDADE FEDERAL DO CEARÁ; EDY SOUSA DE BRITO, CNAT; KIRLEY MARQUES CANUTO, CNPAT; CLAUDIA PESSOA, UNIVERSIDADE FEDERAL DO CEARÁ; GUILHERME JULIAO ZOCOLO, CNPSO. |
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Título: |
Bioguided Fractionation of Phyllanthus spp.: Unveiling Anticancer Potential through Metabolomic Correlation and ADMETox Insights. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Chemistry & Biodiversity, e202400670, 2024. |
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DOI: |
doi.org/10.1002/cbdv.202400670 |
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Idioma: |
Inglês |
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Conteúdo: |
Cancer remains a significant global health concern, with mortality rates steadily rising and prompting an urgent search for effective treatments. This study focuses on the medicinal properties of plants from the Phyllanthus genus, specifically Phyllanthus amarus and Phyllanthus niruri, which have shown promise in traditional medicine. Through bioguided fractionation using preparative high-performance liquid chromatography (HPLC), bioactive compounds were isolated and identified using ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry (UHPLC-QTOF-MSE) and nuclear magnetic resonance (NMR) spectroscopy. Chemometric analyses such as principal component analysis (PCA) aided in understanding metabolite distribution. Biological assays demonstrated cytotoxic activities of specific fractions against cancer cell lines, notably the PhyN 4n fraction from P. niruri, which induced S-phase cell cycle arrest and apoptosis in HL60 cells. These findings underscore the anticancer potential of Phyllanthus species and lay the groundwork for future drug development efforts. The study's integration of advanced analytical techniques, chemometrics, and biological assays provides valuable insights for harnessing natural products in the fight against cancer. |
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Palavras-Chave: |
Citotoxicidade; Dereplication; Desreplicação; Metabolomic; Metabolômica; Natural Products; Produtos Naturais; “quebra-pedra”. |
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Thesagro: |
Câncer. |
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Thesaurus Nal: |
Cancer (genus); Cytotoxicity. |
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Categoria do assunto: |
--
W Química e Física
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 02465naa a2200397 a 4500
001 2166002
005 2024-07-26
008 2024 bl uuuu u00u1 u #d
024 7 $adoi.org/10.1002/cbdv.202400670$2DOI
100 1 $aSILVA, M. F. S.
245 $aBioguided Fractionation of Phyllanthus spp.$bUnveiling Anticancer Potential through Metabolomic Correlation and ADMETox Insights.$h[electronic resource]
260 $c2024
520 $aCancer remains a significant global health concern, with mortality rates steadily rising and prompting an urgent search for effective treatments. This study focuses on the medicinal properties of plants from the Phyllanthus genus, specifically Phyllanthus amarus and Phyllanthus niruri, which have shown promise in traditional medicine. Through bioguided fractionation using preparative high-performance liquid chromatography (HPLC), bioactive compounds were isolated and identified using ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry (UHPLC-QTOF-MSE) and nuclear magnetic resonance (NMR) spectroscopy. Chemometric analyses such as principal component analysis (PCA) aided in understanding metabolite distribution. Biological assays demonstrated cytotoxic activities of specific fractions against cancer cell lines, notably the PhyN 4n fraction from P. niruri, which induced S-phase cell cycle arrest and apoptosis in HL60 cells. These findings underscore the anticancer potential of Phyllanthus species and lay the groundwork for future drug development efforts. The study's integration of advanced analytical techniques, chemometrics, and biological assays provides valuable insights for harnessing natural products in the fight against cancer.
650 $aCancer (genus)
650 $aCytotoxicity
650 $aCâncer
653 $aCitotoxicidade
653 $aDereplication
653 $aDesreplicação
653 $aMetabolomic
653 $aMetabolômica
653 $aNatural Products
653 $aProdutos Naturais
653 $a“quebra-pedra”
700 1 $aSILVA, L. M. A. e
700 1 $aQUINTELA, A. L.
700 1 $aSILVA, F. A. N.
700 1 $aOLIVEIRA, F. DE C. E. DE
700 1 $aLUCIANO, M. C. DOS S.
700 1 $aRODRIGUES, T. H. S.
700 1 $aALEXANDRE FILHO, E. G.
700 1 $aBRITO, E. S. de
700 1 $aCANUTO, K. M.
700 1 $aPESSOA, C.
700 1 $aZOCOLO, G. J.
773 $tChemistry & Biodiversity, e202400670, 2024.
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Registro original: |
Embrapa Agroindústria Tropical (CNPAT) |
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