| |
|
|
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Instrumentação. |
|
Data corrente: |
04/07/2024 |
|
Data da última atualização: |
09/09/2024 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
TEODORO, K. B. R.; ALVARENGA, A. D.; CHAGAS, P. A. M.; LOPES, R. G.; ALVES, F.; STRINGASCI, M. D.; BUZZÁ, H. H.; INADA, N. M.; CORREA, D. S. |
|
Afiliação: |
KELCILENE BRUNA RICARDO TEODORO, FEDERAL UNIVERSITY OF SÃO CARLOS (UFSCAR); AUGUSTA THEREZA DE ALVARENGA, UNIVERSIDADE DE SÃO PAULO (USP); PAULO AUGUSTO MARQUES CHAGAS, UNIVERSIDADE FEDERAL DE SÃO CARLOS (UFSCAR); UNIVERSITY OF SÃO PAULO; UNIVERSITY OF SÃO PAULO; UNIVERSITY OF SÃO PAULO; INSTITUTE OF PHYSICS, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE; UNIVERSITY OF SÃO PAULO; DANIEL SOUZA CORREA, CNPDIA. |
|
Título: |
Synergistic Tetracycline−Curcumin Association in Biocompatible PCL Nanostructured Wound Dressings. |
|
Ano de publicação: |
2024 |
|
Fonte/Imprenta: |
ACS Applied Polymer Materials, v. 6, 2024. |
|
Páginas: |
5089 - 5101 |
|
DOI: |
https://doi.org/10.1021/acsapm.4c00071 |
|
Idioma: |
Português |
|
Conteúdo: |
ABSTRACT: Open injuries, resulting from skin tissue ruptures, can expose the human body to pathogenic bacteria, presenting a significant risk for hospitalized patients and individuals with compromised immune systems. At the same time, developing alternative therapies usinginnovative methods of drug administration is crucial for combating antibacterial resistance. In this study, we present an approach for skin wound healing that synergistically combines a traditional antibiotic and an active natural compound in a polymer nanofibrous wound dressing. The fabrication strategy involved the solution blow spinning technique, which enabled easy, fast, and scalable manufacturing of polymer nanofibrous mats, while poly ε-caprolactone (PCL) was selected as the base polymer, due to its biocompatibility and nontoxicity for human tissues. The selected antibiotic formulation comprised a synergistic combination of tetracycline (TC) and curcumin (CC), aiming to incorporate reduced fractions of TC. Nanofibrous dressings measuring around 200 cm2 could be fabricated during 45 min. The results of physicochemical characterization showed that nanofibrous mats with fewer defects were obtained due to the presence of TC in the formulation, while the presence of CC improved the encapsulation efficiency and enabled a more controlled release of TC. The antimicrobial tests demonstrated that diminishing the quantity of TC in the nanofibrous mats had no discernible impact on their efficacy against Escherichia coli and Staphylococcus aureus. The results of in vitro cytotoxicity and in vivo tests showed that the proposed wound dressings were not cytotoxic (cell viabilities consistently exceeded 95% for human dermal fibroblasts) and did not lead to inflammation or damage in the healing process. Moreover, the study with real wounds on mice showed that the wound dressings containing the synergistic combination of TC and CC exhibited superior efficacy in promoting healing in comparison to the control group. Collectively, these findings demonstrate the potential of the developed nanostructured platfom for wound dressing applications. MenosABSTRACT: Open injuries, resulting from skin tissue ruptures, can expose the human body to pathogenic bacteria, presenting a significant risk for hospitalized patients and individuals with compromised immune systems. At the same time, developing alternative therapies usinginnovative methods of drug administration is crucial for combating antibacterial resistance. In this study, we present an approach for skin wound healing that synergistically combines a traditional antibiotic and an active natural compound in a polymer nanofibrous wound dressing. The fabrication strategy involved the solution blow spinning technique, which enabled easy, fast, and scalable manufacturing of polymer nanofibrous mats, while poly ε-caprolactone (PCL) was selected as the base polymer, due to its biocompatibility and nontoxicity for human tissues. The selected antibiotic formulation comprised a synergistic combination of tetracycline (TC) and curcumin (CC), aiming to incorporate reduced fractions of TC. Nanofibrous dressings measuring around 200 cm2 could be fabricated during 45 min. The results of physicochemical characterization showed that nanofibrous mats with fewer defects were obtained due to the presence of TC in the formulation, while the presence of CC improved the encapsulation efficiency and enabled a more controlled release of TC. The antimicrobial tests demonstrated that diminishing the quantity of TC in the nanofibrous mats had no discernible impact on their efficacy against Escheric... Mostrar Tudo |
|
Palavras-Chave: |
Biomaterial; Skin wound treatments; Solution blow spinning. |
|
Categoria do assunto: |
-- |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1165464/1/P-Synergistic-TetracyclineCurcumin-Association-in-Biocompatible.pdf
|
|
Marc: |
LEADER 02963naa a2200277 a 4500
001 2165464
005 2024-09-09
008 2024 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1021/acsapm.4c00071$2DOI
100 1 $aTEODORO, K. B. R.
245 $aSynergistic Tetracycline−Curcumin Association in Biocompatible PCL Nanostructured Wound Dressings.$h[electronic resource]
260 $c2024
300 $a5089 - 5101
520 $aABSTRACT: Open injuries, resulting from skin tissue ruptures, can expose the human body to pathogenic bacteria, presenting a significant risk for hospitalized patients and individuals with compromised immune systems. At the same time, developing alternative therapies usinginnovative methods of drug administration is crucial for combating antibacterial resistance. In this study, we present an approach for skin wound healing that synergistically combines a traditional antibiotic and an active natural compound in a polymer nanofibrous wound dressing. The fabrication strategy involved the solution blow spinning technique, which enabled easy, fast, and scalable manufacturing of polymer nanofibrous mats, while poly ε-caprolactone (PCL) was selected as the base polymer, due to its biocompatibility and nontoxicity for human tissues. The selected antibiotic formulation comprised a synergistic combination of tetracycline (TC) and curcumin (CC), aiming to incorporate reduced fractions of TC. Nanofibrous dressings measuring around 200 cm2 could be fabricated during 45 min. The results of physicochemical characterization showed that nanofibrous mats with fewer defects were obtained due to the presence of TC in the formulation, while the presence of CC improved the encapsulation efficiency and enabled a more controlled release of TC. The antimicrobial tests demonstrated that diminishing the quantity of TC in the nanofibrous mats had no discernible impact on their efficacy against Escherichia coli and Staphylococcus aureus. The results of in vitro cytotoxicity and in vivo tests showed that the proposed wound dressings were not cytotoxic (cell viabilities consistently exceeded 95% for human dermal fibroblasts) and did not lead to inflammation or damage in the healing process. Moreover, the study with real wounds on mice showed that the wound dressings containing the synergistic combination of TC and CC exhibited superior efficacy in promoting healing in comparison to the control group. Collectively, these findings demonstrate the potential of the developed nanostructured platfom for wound dressing applications.
653 $aBiomaterial
653 $aSkin wound treatments
653 $aSolution blow spinning
700 1 $aALVARENGA, A. D.
700 1 $aCHAGAS, P. A. M.
700 1 $aLOPES, R. G.
700 1 $aALVES, F.
700 1 $aSTRINGASCI, M. D.
700 1 $aBUZZÁ, H. H.
700 1 $aINADA, N. M.
700 1 $aCORREA, D. S.
773 $tACS Applied Polymer Materials$gv. 6, 2024.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Instrumentação (CNPDIA) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
| Registros recuperados : 5 | |
| 2. |  | COSTA, V. P. V. da; SANTOS, D. M. dos; ANDRE, R. S.; LOPES, R. G.; INADA, N. M.; CORREA, D. S. Bilayer nonwovens using natural rubber, poly(lactic acid) and bactericidal nanoparticles for wound dressings. Materials Today Communications, v. 37, 107260, 2023. 13 p.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 4 |
| Biblioteca(s): Embrapa Instrumentação. |
|    |
| 3. | | TEODORO, K. B. R.; ALVARENGA, A. D.; CHAGAS, P. A. M.; LOPES, R. G.; ALVES, F.; STRINGASCI, M. D.; BUZZÁ, H. H.; INADA, N. M.; CORREA, D. S. Synergistic Tetracycline−Curcumin Association in Biocompatible PCL Nanostructured Wound Dressings. ACS Applied Polymer Materials, v. 6, 2024. 5089 - 5101| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 2 |
| Biblioteca(s): Embrapa Instrumentação. |
|  |
| 4. | | GRIZZO, A.; SANTOS, D. M. dos; COSTA, V. P. V. da; LOPES, R. G.; INADA, N. M.; CORREA, D. S.; CAMPANA-FILHO, S. P. Multifunctional bilayer membranes composed of poly(lactic acid), beta-chitin whiskers and silver nanoparticles for wound dressing applications. International Journal of Biological Macromolecules, v. 251, 126314, 2023.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Instrumentação. |
| |
| 5. | | TEODORO, K. B. R.; ALVARENGA, A. D.; OLIVEIRA, L. F. R.; CHAGAS, P. A. M.; LOPES. R. G.; ANDRE, R. S.; MERCANTE, L. A.; ALVES, F.; STRINGASCI, M. D.; BUZZA, H. H.; INADA, N. M.; CORREA, D. S. Fast Fabrication of Multifunctional PCL/Curcumin Nanofibrous Membranes for Wound Dressings. ACS Applied Bio Materials, v. 6, 2023. 2325–2337| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 2 |
| Biblioteca(s): Embrapa Instrumentação. |
| |
| Registros recuperados : 5 | |
|
| Nenhum registro encontrado para a expressão de busca informada. |
|
|
