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Registro Completo |
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Biblioteca(s): |
Embrapa Florestas. |
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Data corrente: |
10/01/2022 |
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Data da última atualização: |
14/02/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
LOURENÇON, T. V.; LIMA, G. G. de; RIBEIRO, C. S. P.; HANSEL, F. A.; MACIEL, G. M.; SILVA, K. da; WINNISCHOFER, S. M. B.; BOLZON DE MUNIZ, G. I.; MAGALHAES, W. L. E. |
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Afiliação: |
TAINISE V. LOURENÇON, Doutoranda da UFPR; GABRIEL G. DE LIMA, Pós-doutorando da UFPR; CAROLINA S. P. RIBEIRO, UFPR; FABRICIO AUGUSTO HANSEL, CNPF; GISELLE M. MACIEL, UFPR; KRISLE DA SILVA, CNPF; SHEILA M. B. WINNISCHOFER, UTFPR; GRACIELA I. BOLZON DE MUNIZ, UFPR; WASHINGTON LUIZ ESTEVES MAGALHAES, CNPF. |
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Título: |
Antioxidant, antibacterial and antitumoural activities of kraft lignin from hardwood fractionated by acid precipitation. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
International Journal of Biological Macromolecules, v. 166, p. 1535-1542, Jan. 2021. |
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DOI: |
https://doi.org/10.1016/j.ijbiomac.2020.11.033 |
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Idioma: |
Inglês |
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Conteúdo: |
Kraft lignin, so far useful for energy generation, has been gathering considerable attention as an alternative ma-terial to replace fossil-based resources mainly due to its high phenolic content. However, the wide molecularweight distribution and chemical composition heterogeneity led to the development of fractionation methods.Herein, to narrow such characteristics weusedeucalypt kraft lignin fractionated atpH's 9,7, 5 and 3 bysequentialacid precipitation. These lignin fractions werefirst characterised by simultaneous pyrolysis andtrimethylsilylation (SPyT) with N-Methyl-N-(trimethylsilyl) trifluoroacetamide with posterior tests of antioxi-dant, antibacterial, and antitumour activities. We observed higher ratio of syringyl/guaiacyl groups and increasein antioxidant activity in those fractions with lower molecular weight (precipitated at lower pH's). Fractions pre-cipitated at pH's 9 and 7 have shown an outstanding antibacterial activity againstfive bacteria. Moreover, frac-tions 7 and 5 presented at cytotoxicity tests higher ability to inhibit the growth of U87MG and T98G gliomacells, while only a slight inhibition of adult humanfibroblasts (non-tumour cells) was detected. |
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Palavras-Chave: |
Antibacterial; Antitumoral; Antitumoural; Hardwood lignin; IC50; Radical scavenging; Technical lignin. |
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Thesagro: |
Antioxidante; Bactericida; Lignina. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 02272naa a2200349 a 4500
001 2138967
005 2022-02-14
008 2021 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.ijbiomac.2020.11.033$2DOI
100 1 $aLOURENÇON, T. V.
245 $aAntioxidant, antibacterial and antitumoural activities of kraft lignin from hardwood fractionated by acid precipitation.$h[electronic resource]
260 $c2021
520 $aKraft lignin, so far useful for energy generation, has been gathering considerable attention as an alternative ma-terial to replace fossil-based resources mainly due to its high phenolic content. However, the wide molecularweight distribution and chemical composition heterogeneity led to the development of fractionation methods.Herein, to narrow such characteristics weusedeucalypt kraft lignin fractionated atpH's 9,7, 5 and 3 bysequentialacid precipitation. These lignin fractions werefirst characterised by simultaneous pyrolysis andtrimethylsilylation (SPyT) with N-Methyl-N-(trimethylsilyl) trifluoroacetamide with posterior tests of antioxi-dant, antibacterial, and antitumour activities. We observed higher ratio of syringyl/guaiacyl groups and increasein antioxidant activity in those fractions with lower molecular weight (precipitated at lower pH's). Fractions pre-cipitated at pH's 9 and 7 have shown an outstanding antibacterial activity againstfive bacteria. Moreover, frac-tions 7 and 5 presented at cytotoxicity tests higher ability to inhibit the growth of U87MG and T98G gliomacells, while only a slight inhibition of adult humanfibroblasts (non-tumour cells) was detected.
650 $aAntioxidante
650 $aBactericida
650 $aLignina
653 $aAntibacterial
653 $aAntitumoral
653 $aAntitumoural
653 $aHardwood lignin
653 $aIC50
653 $aRadical scavenging
653 $aTechnical lignin
700 1 $aLIMA, G. G. de
700 1 $aRIBEIRO, C. S. P.
700 1 $aHANSEL, F. A.
700 1 $aMACIEL, G. M.
700 1 $aSILVA, K. da
700 1 $aWINNISCHOFER, S. M. B.
700 1 $aBOLZON DE MUNIZ, G. I.
700 1 $aMAGALHAES, W. L. E.
773 $tInternational Journal of Biological Macromolecules$gv. 166, p. 1535-1542, Jan. 2021.
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Registro original: |
Embrapa Florestas (CNPF) |
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