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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
21/06/2021 |
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Data da última atualização: |
10/06/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
PARRA, G. G.; CORREA, D. S.; SILVEIRA-ALVES JUNIOR, E.; ALMEIDA, L. M.; SOUZA, M. A. R.; DE BONI, L.; MISOGUTI, L.; MENDONÇA, C. R.; ZÍLIO, S. C.; BARBOSA NETO, N. M.; BORISSEVITCH, I. E.; GONÇALVES, P. J. |
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Afiliação: |
DANIEL SOUZA CORREA, CNPDIA. |
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Título: |
Effects of meso-tetrakis (4-sulfonatophenyl) porphyrin (TPPS4) aggregation on its spectral and kinetic characteristics and singlet oxygen production. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, v. 261, e120063, 2021. |
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Páginas: |
1-7 |
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ISSN: |
1386-1425 |
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DOI: |
https://doi.org/10.1016/j.saa.2021.120063 |
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Idioma: |
Inglês |
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Conteúdo: |
The present work reports the effects of meso-tetrakis (4-sulfonatophenyl) porphyrin (TPPS4) aggregation on its excited states absorption spectra, triplet states quenching by molecular oxygen and singlet oxygen production. Experimental techniques such as optical absorption, Z-scan with a white light continuum source and the Laser Flash Photolysis were used to fulfil the study. J-aggregates possess reverse saturable absorption in the 505–660 nm spectral range with a peak centered close to 540 nm. These facts together with their fast relaxation time suggest that they can be employed as material for ultrafast optical limiting and switching. Even though aggregation reduces the porphyrin excited-state lifetimes and quantum yields, it does not reduce the probability of the contact between the quencher and the excited aggregate. Aggregation does not change the contribution of energy transfer mechanisms to triplet state quenching by molecular oxygen. The production of singlet oxygen, the intense absorption in the phototherapeutic window and the high efficiency of conversion of light energy into heat, allow consider J-aggregates as a theranostic agent for photomedicine. It is proposed to use J-aggregates for diagnostics by photoacoustic images and in combination with a near-infrared photodynamic/photothermal dual mode therapy, thus improving synergistically the therapeutic response. |
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Palavras-Chave: |
Photodynamic therapy; Photophysical characterization; Photothermal therapy; Theranostics. |
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Categoria do assunto: |
-- |
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Marc: |
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001 2132447
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008 2021 bl uuuu u00u1 u #d
022 $a1386-1425
024 7 $ahttps://doi.org/10.1016/j.saa.2021.120063$2DOI
100 1 $aPARRA, G. G.
245 $aEffects of meso-tetrakis (4-sulfonatophenyl) porphyrin (TPPS4) aggregation on its spectral and kinetic characteristics and singlet oxygen production.$h[electronic resource]
260 $c2021
300 $a1-7
520 $aThe present work reports the effects of meso-tetrakis (4-sulfonatophenyl) porphyrin (TPPS4) aggregation on its excited states absorption spectra, triplet states quenching by molecular oxygen and singlet oxygen production. Experimental techniques such as optical absorption, Z-scan with a white light continuum source and the Laser Flash Photolysis were used to fulfil the study. J-aggregates possess reverse saturable absorption in the 505–660 nm spectral range with a peak centered close to 540 nm. These facts together with their fast relaxation time suggest that they can be employed as material for ultrafast optical limiting and switching. Even though aggregation reduces the porphyrin excited-state lifetimes and quantum yields, it does not reduce the probability of the contact between the quencher and the excited aggregate. Aggregation does not change the contribution of energy transfer mechanisms to triplet state quenching by molecular oxygen. The production of singlet oxygen, the intense absorption in the phototherapeutic window and the high efficiency of conversion of light energy into heat, allow consider J-aggregates as a theranostic agent for photomedicine. It is proposed to use J-aggregates for diagnostics by photoacoustic images and in combination with a near-infrared photodynamic/photothermal dual mode therapy, thus improving synergistically the therapeutic response.
653 $aPhotodynamic therapy
653 $aPhotophysical characterization
653 $aPhotothermal therapy
653 $aTheranostics
700 1 $aCORREA, D. S.
700 1 $aSILVEIRA-ALVES JUNIOR, E.
700 1 $aALMEIDA, L. M.
700 1 $aSOUZA, M. A. R.
700 1 $aDE BONI, L.
700 1 $aMISOGUTI, L.
700 1 $aMENDONÇA, C. R.
700 1 $aZÍLIO, S. C.
700 1 $aBARBOSA NETO, N. M.
700 1 $aBORISSEVITCH, I. E.
700 1 $aGONÇALVES, P. J.
773 $tSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy$gv. 261, e120063, 2021.
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