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Registro Completo |
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
30/10/2019 |
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Data da última atualização: |
30/10/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
JOAQUIM, L. B.; CHUD, T. C. S.; MARCHESI, J. A. P.; SAVEGNAGO, R. P.; BUZANKAS, M. E.; ZANELLA, R.; CANTAO, M. E.; PEIXOTO, J. de O.; LEDUR, M. C.; IRGANG, R.; MUNARI, D. P. |
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Afiliação: |
LETÍCIA BORGES JOAQUIM, UNESP/Jaboticabal; TATIANE CRISTINA SELEGUIM CHUD, UNESP/Jaboticabal; JORGE AUGUSTO PETROLLI MARCHESI, UNESP/Jaboticabal; RODRIGO PELICIONI SAVEGNAGO, UNESP/Jaboticabal; MARCOS ELI BUZANSKAS, UFPB; RICARDO ZANELLA, UPF; MAURICIO EGIDIO CANTAO, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; MONICA CORREA LEDUR, CNPSA; RENATO IRGANG, UFSC; DANÍSIO PRADO MUNARI, UNESP/Jaboticabal. |
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Título: |
Genomic structure of a crossbred landrace pig population. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Plos One, v. 14, n.2, e0212266, 2019. |
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DOI: |
10.1371/journal.pone.0212266 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Single nucleotide polymorphism (SNP) markers are used to study population structure and conservation genetics, which permits assessing similarities regarding the linkage disequilibrium and information about the relationship among individuals. To investigate the population genomic structure of 300 females and 25 males from a commercial maternal pig line we analyzed linkage disequilibrium extent, inbreeding coefficients using genomic and conventional pedigree data, and population stratification. The average linkage disequilibrium (r2 ) was 0.291 ± 0.312 for all adjacent SNPs, distancing less than 100 Kb (kilobase) between markers. The average inbreeding coefficients obtained from runs of homozygosity (ROH) and pedigree analyses were 0.119 and 0.0001, respectively. Low correlation was observed between the inbreeding coefficients possibly as a result of genetic recombination effect accounted for the ROH estimates or caused by pedigree identification errors. A large number of long ROHs might indicate recent inbreeding events in the studied population. A total of 36 homozygous segments were found in more than 30% of the population and these ROH harbor genes associated with reproductive traits. The population stratification analysis indicated that this population was possibly originated from two distinct populations, which is a result from crossings between the eastern and western breeds used in the formation of the line. Our findings provide support to understand the genetic structure of swine populations and may assist breeding companies to avoid a high level of inbreeding coefficients to maintain genetic diversity, showing the effectiveness of using genomewide SNP information for quantifying inbreeding when the pedigree was incomplete or incorrect. MenosAbstract: Single nucleotide polymorphism (SNP) markers are used to study population structure and conservation genetics, which permits assessing similarities regarding the linkage disequilibrium and information about the relationship among individuals. To investigate the population genomic structure of 300 females and 25 males from a commercial maternal pig line we analyzed linkage disequilibrium extent, inbreeding coefficients using genomic and conventional pedigree data, and population stratification. The average linkage disequilibrium (r2 ) was 0.291 ± 0.312 for all adjacent SNPs, distancing less than 100 Kb (kilobase) between markers. The average inbreeding coefficients obtained from runs of homozygosity (ROH) and pedigree analyses were 0.119 and 0.0001, respectively. Low correlation was observed between the inbreeding coefficients possibly as a result of genetic recombination effect accounted for the ROH estimates or caused by pedigree identification errors. A large number of long ROHs might indicate recent inbreeding events in the studied population. A total of 36 homozygous segments were found in more than 30% of the population and these ROH harbor genes associated with reproductive traits. The population stratification analysis indicated that this population was possibly originated from two distinct populations, which is a result from crossings between the eastern and western breeds used in the formation of the line. Our findings provide support to understand the gen... Mostrar Tudo |
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Palavras-Chave: |
SNP. |
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Thesagro: |
Genética; Marcador Genético; Polimorfismo Genético; Suíno. |
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Thesaurus Nal: |
Genetic markers; Genomics; Polymorphism; Swine. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02737naa a2200361 a 4500
001 2113663
005 2019-10-30
008 2019 bl uuuu u00u1 u #d
024 7 $a10.1371/journal.pone.0212266$2DOI
100 1 $aJOAQUIM, L. B.
245 $aGenomic structure of a crossbred landrace pig population.$h[electronic resource]
260 $c2019
520 $aAbstract: Single nucleotide polymorphism (SNP) markers are used to study population structure and conservation genetics, which permits assessing similarities regarding the linkage disequilibrium and information about the relationship among individuals. To investigate the population genomic structure of 300 females and 25 males from a commercial maternal pig line we analyzed linkage disequilibrium extent, inbreeding coefficients using genomic and conventional pedigree data, and population stratification. The average linkage disequilibrium (r2 ) was 0.291 ± 0.312 for all adjacent SNPs, distancing less than 100 Kb (kilobase) between markers. The average inbreeding coefficients obtained from runs of homozygosity (ROH) and pedigree analyses were 0.119 and 0.0001, respectively. Low correlation was observed between the inbreeding coefficients possibly as a result of genetic recombination effect accounted for the ROH estimates or caused by pedigree identification errors. A large number of long ROHs might indicate recent inbreeding events in the studied population. A total of 36 homozygous segments were found in more than 30% of the population and these ROH harbor genes associated with reproductive traits. The population stratification analysis indicated that this population was possibly originated from two distinct populations, which is a result from crossings between the eastern and western breeds used in the formation of the line. Our findings provide support to understand the genetic structure of swine populations and may assist breeding companies to avoid a high level of inbreeding coefficients to maintain genetic diversity, showing the effectiveness of using genomewide SNP information for quantifying inbreeding when the pedigree was incomplete or incorrect.
650 $aGenetic markers
650 $aGenomics
650 $aPolymorphism
650 $aSwine
650 $aGenética
650 $aMarcador Genético
650 $aPolimorfismo Genético
650 $aSuíno
653 $aSNP
700 1 $aCHUD, T. C. S.
700 1 $aMARCHESI, J. A. P.
700 1 $aSAVEGNAGO, R. P.
700 1 $aBUZANKAS, M. E.
700 1 $aZANELLA, R.
700 1 $aCANTAO, M. E.
700 1 $aPEIXOTO, J. de O.
700 1 $aLEDUR, M. C.
700 1 $aIRGANG, R.
700 1 $aMUNARI, D. P.
773 $tPlos One$gv. 14, n.2, e0212266, 2019.
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Registro original: |
Embrapa Suínos e Aves (CNPSA) |
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