| |
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com rosangela.lacerda@embrapa.br. |
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Gado de Leite. |
|
Data corrente: |
03/12/2018 |
|
Data da última atualização: |
24/01/2023 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
BARROS, P. A. V. de; ANDRADE, M. E. R.; GENEROSO, S. de V.; MIRANDA, S. E. M.; REIS, D. C. dos; LEOCÁDIO, P. C. L.; SOUZA, E. L. de S. e; MARTINS, F. dos S.; GAMA, M. A. S. da; CASSALI, G. D.; LEITE, J. I. A.; FERNANDES, S. O. A.; CARDOSO, V. N. |
|
Afiliação: |
PATRÍCIA APARECIDA VIEIRA DE BARROS, UFMG; MARIA EMÍLIA RABELO ANDRADE, UFMG; SIMONE DE VASCONCELOS GENEROSO, UFMG; SUED EUSTÁQUIO MENDES MIRANDA, UFMG; DIEGO CARLOS DOS REIS, UFMG; PAOLA CAROLINE LACERDA LEOCÁDIO, UFMG; ÉRICKA LORENNA DE SALES E SOUZA, UFMG; FLAVIANO DOS SANTOS MARTINS, UFMG; MARCO ANTONIO SUNDFELD DA GAMA, CNPGL; GEOVANNI DANTAS CASSALI, UFMG; JACQUELINE ISAURA ALVAREZ LEITE, UFMG; SIMONE ODÍLIA ANTUNES FERNANDES, UFMG; VALBERT NASCIMENTO CARDOSO, UFMG. |
|
Título: |
Conjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model. |
|
Ano de publicação: |
2018 |
|
Fonte/Imprenta: |
Biomedicine & Pharmacotherapy, v. 103, p. 1567-1576, 2018. |
|
DOI: |
10.1016/j.biopha.2018.04.133 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Abstract BACKGROUND: Studies have showed the protective effects of conjugated linoleic acid (CLA) on intestinal epithelium, modulating host immune and inflammatory responses on intestinal diseases. OBJECTIVE: To evaluate the preventive effects of CLA on the intestinal mucositis induced by 5-FU in a murine model. METHODS: Sixty-four BALB/c mice were randomly divided into four groups: Control (CTL), fed a standard chow diet; CLAs, fed a diet supplemented with CLA; Mucositis (5-FU), fed a standard chow diet and underwent mucositis induction and CLAs 5-FU, fed a diet supplemented with CLA and underwent mucositis induction. Mucositis was induced by intraperitoneal injection of 300 mg/kg 5-FU. After 72 h, the animals were euthanized and intestinal permeability, bacterial translocation, inflammatory mediators, and intestinal histology were evaluated. RESULTS: Mice in the CLAs 5-FU group showed reduced weight loss compared to those in the 5-FU group (p < 0.005). Furthermore, the results also showed that the treatment with CLA reduced intestinal permeability, bacterial translocation, and biomarkers of inflammatory response besides minor damage to ZO-1 and occludin with maintenance of the integrity of the intestinal epithelium and a favorable balance between the inflammatory and regulatory cytokines. CONCLUSION: This study suggests that CLA reduced the adverse effects from 5-FU administration on the intestinal mucosa. |
|
Palavras-Chave: |
Bacterial translocation; Conjugated linoleic acids; Intestinal damage; Mucositis; Tight junction protein. |
|
Thesaurus Nal: |
Cytokines. |
|
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
|
Marc: |
LEADER 02555naa a2200349 a 4500
001 2100591
005 2023-01-24
008 2018 bl uuuu u00u1 u #d
024 7 $a10.1016/j.biopha.2018.04.133$2DOI
100 1 $aBARROS, P. A. V. de
245 $aConjugated linoleic acid prevents damage caused by intestinal mucositis induced by 5-fluorouracil in an experimental model.$h[electronic resource]
260 $c2018
520 $aAbstract BACKGROUND: Studies have showed the protective effects of conjugated linoleic acid (CLA) on intestinal epithelium, modulating host immune and inflammatory responses on intestinal diseases. OBJECTIVE: To evaluate the preventive effects of CLA on the intestinal mucositis induced by 5-FU in a murine model. METHODS: Sixty-four BALB/c mice were randomly divided into four groups: Control (CTL), fed a standard chow diet; CLAs, fed a diet supplemented with CLA; Mucositis (5-FU), fed a standard chow diet and underwent mucositis induction and CLAs 5-FU, fed a diet supplemented with CLA and underwent mucositis induction. Mucositis was induced by intraperitoneal injection of 300 mg/kg 5-FU. After 72 h, the animals were euthanized and intestinal permeability, bacterial translocation, inflammatory mediators, and intestinal histology were evaluated. RESULTS: Mice in the CLAs 5-FU group showed reduced weight loss compared to those in the 5-FU group (p < 0.005). Furthermore, the results also showed that the treatment with CLA reduced intestinal permeability, bacterial translocation, and biomarkers of inflammatory response besides minor damage to ZO-1 and occludin with maintenance of the integrity of the intestinal epithelium and a favorable balance between the inflammatory and regulatory cytokines. CONCLUSION: This study suggests that CLA reduced the adverse effects from 5-FU administration on the intestinal mucosa.
650 $aCytokines
653 $aBacterial translocation
653 $aConjugated linoleic acids
653 $aIntestinal damage
653 $aMucositis
653 $aTight junction protein
700 1 $aANDRADE, M. E. R.
700 1 $aGENEROSO, S. de V.
700 1 $aMIRANDA, S. E. M.
700 1 $aREIS, D. C. dos
700 1 $aLEOCÁDIO, P. C. L.
700 1 $aSOUZA, E. L. de S. e
700 1 $aMARTINS, F. dos S.
700 1 $aGAMA, M. A. S. da
700 1 $aCASSALI, G. D.
700 1 $aLEITE, J. I. A.
700 1 $aFERNANDES, S. O. A.
700 1 $aCARDOSO, V. N.
773 $tBiomedicine & Pharmacotherapy$gv. 103, p. 1567-1576, 2018.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Gado de Leite (CNPGL) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
| Registros recuperados : 3 | |
| 1. |  | PAPPAS JUNIOR, G. J.; MIRANDA, R. P.; MARTINS, N. F.; TOGAWA, R. C.; COSTA, M. M. C. SisGen: a corba-based data management program for DNA sequencing projects. In: INTERNATIONAL WORKSHOP, DILS, 5., 2008, Evry, França. Proceedings: Berlin Heidelberg: Springer, 2008.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
|    |
| 2. | | GOMES COPELAND, K. K. P.; LEDO, A. da S.; ALMEIDA, F. T. C. de; MIRANDA, R. P.; SANTOS, I. R. I. Assessing the viability of cryopreserved coconut zygotic embryos by electrolytic conductivity and potassium leaching. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 47, n. 1, p. 8-13, jan. 2012. Título em português: Avaliação da viabilidade de embriões de coqueiro criopreservados por meio de condutividade elétrica e lixiviação de potássio.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia; Embrapa Tabuleiros Costeiros; Embrapa Unidades Centrais. |
| |
| 3. | | KIRCH, R. P.; SCHWAMBACH, J.; BASTOLLA, F. M.; PAZZINI, F.; PIZZOLI, G.; ROESLER, G. A.; MIRANDA, R. P.; CARAZZOLLE, M. F.; BRONDANI, R. V.; COELHO, A. S. G.; GRATTAPAGLIA, D.; BROMMONSCHENKEL, S. H.; PAPPAS JÚNIOR, G. J.; PEREIRA, G. A. G.; FETT-NETO, A. G.; CASCARDO, J. C. M.; PASQUALI, G. Projeto Genolyptus: seqüenciamento e análise de transcritos de plântulas de Eucalyptus grandis submetidos a diferentes estímulos. In: CONGRESSO BRASILEIRO DE GENÉTICA, 51., 2005, Águas de Lindóia, SP. A era da genômica: da bioestatística à bioinformática: anais. Ribeirão Preto, SP: Sociedade Brasileira de Genética, 2005. p. 528.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
| |
| Registros recuperados : 3 | |
|
| Expressão de busca inválida. Verifique!!! |
|
|
