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 | Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Oriental. Para informações adicionais entre em contato com cpatu.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
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Data corrente: |
06/10/2017 |
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Data da última atualização: |
22/12/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
GHIZONI, C. V. C.; AMES, A. P. A.; LAMEIRA, O. A.; AMADO, C. A. B.; NAKANISHI, A. B. S.; BRACHT, L.; NATALI, M. R. M.; PERALTA, R. M.; BRACHT, A.; COMAR, J. F. |
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Afiliação: |
Cristiane V. Castro Ghizoni, UEM; Ana P. Arssufi Ames, UEM; OSMAR ALVES LAMEIRA, CPATU; Ciomar A. Bersani Amado, UEM; Anacharis B. Sá Nakanishi, UEM; Lívia Bracht, UEM; Maria R. Marçal Natali, UEM; Rosane M. Peralta, UEM; Adelar Bracht, UEM; Jurandir F. Comar, UEM. |
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Título: |
Anti-inflammatory and antioxidant actions of Copaiba oil are related to liver cell modifications in arthritic rats. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Journal of Cellular Biochemistry, v. 118, n. 10, p. 3409-3423, 2017. |
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DOI: |
10.1002/jcb.25998 |
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Idioma: |
Inglês |
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Conteúdo: |
The present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman rats were distributed into the following groups: control (healthy) rats; control rats treated with copaiba oil at the doses of 0.58 and 1.15, arthritic rats, and arthritic rats treated with copaiba oil . The oil was administrated orally once a day during 18 days after arthritis induction. Both doses of copaiba oil improved the paw edema and the dose of improved the swollen adrenals and lymph nodes besides decreasing the plasmatic myeloperoxidase activity (30%) of arthritic rats. Copaiba oil abolished the increases of protein carbonyl groups and reactive oxygen species in the liver and both doses increased the liver GSH content and the catalase activity in arthritic rats. Copaiba oil decreased glycolysis (65%), glycogenolysis (58%), and gluconeogenesis (30%) in the liver of arthritic animals. However, gluconeogenesis was also diminished by the treatment of control rats, which presented lower body weight gain (45%) and diminished number of hepatocytes per liver area (20%) associated to higher liver weight (+29%) and increased hepatocyte area (+13%). The results reveal that copaiba oil presented systemic anti-inflammatory and antioxidant actions in arthritic rats. These beneficial effects, however, were counterbalanced by harmful modifications in the liver cell metabolism and morphology of healthy control rats. J. MenosThe present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman rats were distributed into the following groups: control (healthy) rats; control rats treated with copaiba oil at the doses of 0.58 and 1.15, arthritic rats, and arthritic rats treated with copaiba oil . The oil was administrated orally once a day during 18 days after arthritis induction. Both doses of copaiba oil improved the paw edema and the dose of improved the swollen adrenals and lymph nodes besides decreasing the plasmatic myeloperoxidase activity (30%) of arthritic rats. Copaiba oil abolished the increases of protein carbonyl groups and reactive oxygen species in the liver and both doses increased the liver GSH content and the catalase activity in arthritic rats. Copaiba oil decreased glycolysis (65%), glycogenolysis (58%), and gluconeogenesis (30%) in the liver of arthritic animals. However, gluconeogenesis was also diminished by the treatment of control rats, which presented lower body weight gain (45%) and diminished number of hepatocytes per liver area (20%) associated to higher liver weight (+29%) and increased hepatocyte area (+13%). The results reveal that copaiba oil presented systemic anti-inflammatory and antioxidant actions in arthritic rats. Th... Mostrar Tudo |
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Palavras-Chave: |
Toxicidade. |
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Thesagro: |
Copaíba; Fígado; Metabolismo; Óleo. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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Marc: |
LEADER 02525naa a2200301 a 4500
001 2076843
005 2021-12-22
008 2017 bl uuuu u00u1 u #d
024 7 $a10.1002/jcb.25998$2DOI
100 1 $aGHIZONI, C. V. C.
245 $aAnti-inflammatory and antioxidant actions of Copaiba oil are related to liver cell modifications in arthritic rats.$h[electronic resource]
260 $c2017
520 $aThe present study investigated the action of copaiba oil (Copaifera reticulata) on the systemic inflammation, oxidative status, and liver cell metabolism of rats with adjuvant-induced arthritis. The later is an experimental autoimmune pathology that shares many features with the human rheumatoid arthritis. Holtzman rats were distributed into the following groups: control (healthy) rats; control rats treated with copaiba oil at the doses of 0.58 and 1.15, arthritic rats, and arthritic rats treated with copaiba oil . The oil was administrated orally once a day during 18 days after arthritis induction. Both doses of copaiba oil improved the paw edema and the dose of improved the swollen adrenals and lymph nodes besides decreasing the plasmatic myeloperoxidase activity (30%) of arthritic rats. Copaiba oil abolished the increases of protein carbonyl groups and reactive oxygen species in the liver and both doses increased the liver GSH content and the catalase activity in arthritic rats. Copaiba oil decreased glycolysis (65%), glycogenolysis (58%), and gluconeogenesis (30%) in the liver of arthritic animals. However, gluconeogenesis was also diminished by the treatment of control rats, which presented lower body weight gain (45%) and diminished number of hepatocytes per liver area (20%) associated to higher liver weight (+29%) and increased hepatocyte area (+13%). The results reveal that copaiba oil presented systemic anti-inflammatory and antioxidant actions in arthritic rats. These beneficial effects, however, were counterbalanced by harmful modifications in the liver cell metabolism and morphology of healthy control rats. J.
650 $aCopaíba
650 $aFígado
650 $aMetabolismo
650 $aÓleo
653 $aToxicidade
700 1 $aAMES, A. P. A.
700 1 $aLAMEIRA, O. A.
700 1 $aAMADO, C. A. B.
700 1 $aNAKANISHI, A. B. S.
700 1 $aBRACHT, L.
700 1 $aNATALI, M. R. M.
700 1 $aPERALTA, R. M.
700 1 $aBRACHT, A.
700 1 $aCOMAR, J. F.
773 $tJournal of Cellular Biochemistry$gv. 118, n. 10, p. 3409-3423, 2017.
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Embrapa Amazônia Oriental (CPATU) |
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| 1. |  | VILAS BOAS, O.; IMBACH, A. C.; MAZZARINO, M. J.; BONNEMANN, A.; BEER, J. Decomposicao do litter e mineralizacao do nitrogenio da materia organica, do solo sob quatro sistemas agroflorestais em Turrialba, Costa Rica. In: ENCONTRO BRASILEIRO DE ECONOMIA E PLANEJAMENTO FLORESTAL, 2., 1991, Curitiba. Anais. Colombo: EMBRAPA-CNPF, 1992. v. 1, p. 337-356.| Biblioteca(s): Embrapa Florestas. |
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| 2. | | LIMA, F.; VILAS BOAS, O.; LIMA, J.; AGUIAR, A. V. de; MACHADO, J. A. R.; FREITAS, M. L. M. Genetic parameters of Pinus caribaea var. bahamensis in an open-pollinated orchard in the municipality of Assisi, São Paulo. In: IUFRO WORLD CONGRESS, 26., 2024, Stockholm. Book of abstracts: forest & society towards 2050. Uppsala: IUFRO, 2024. p. 2699.| Tipo: Resumo em Anais de Congresso |
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| 3. | | SANTOS, T.; LIMA, J.; VILAS BOAS, O.; MACHADO, J. A. R.; FREITAS, M. L. M.; MORALES, M. M.; AGUIAR, A. V. de. Selection of progenies of Pinus caribaea var. bahamensis for the production and quality of gum resin. In: North American Forest Genetics Society Bienal Conference, 2., 2024, Oaxaca. Abstracts [...]. [Oaxaca: NAFGS, 2024]. Poster.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Florestas. |
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| 4. | | SOUZA, F. B. de; SOUZA, D. C. L.; SOUZA, F. H. de; AGUIAR, A. V. de; VILAS BOAS, O.; FREITAS, M. L. M.; SEBBENN, A. M. Estimation of genetic parameters in Pinus tecunumanii. In: 2014 IUFRO FOREST TREE BREEDING CONFERENCE, 2014, Prague. Book of abstracts. [S.l.]: IUFRO: Faculty of Forestry and Wood Sciences, 2014. p. 63. Disponibilizado online. P 50.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Florestas. |
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| Registros recuperados : 4 | |
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