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Registro Completo
Biblioteca(s):  Embrapa Caprinos e Ovinos.
Data corrente:  04/07/2017
Data da última atualização:  04/07/2017
Autoria:  PETERS, J. P.; BERGMAN, E. N.; ELLIOT, J. M.
Título:  Influence of vitamin B-12 status on hepatic propionic acid uptake in sheep.
Ano de publicação:  1983
Fonte/Imprenta:  The Journal of Nutrition, v. 113, n. 6, p. 1221-1228, Jul. 1983.
Idioma:  Inglês
Conteúdo:  Abstract: Pregnant ewes were fed a depletion diet low in cobalt (0.06 ppm) for 3 1/2 months. Chronic catheters were implanted 8 weeks postpartum and 7 experiments were performed on these nonlactating vitamin B-12-depleted sheep (de-B12: 340 +/- 30 ng vitamin B-12 per gram wet liver) prior to repletion by intramuscular injection of hydroxocobalamin. Six experiments were then repeated after vitamin B-12 repletion (re-B12: 2220 +/- 50 ng vitamin B-12 per gram wet liver). The hepatic extraction ratios (HER) in continuously fed sheep were 0.81 and 0.77 for de-B12 and re-B12 corresponding to net hepatic uptakes of 460 +/- 50 and 440 +/- 40 mumol propionate per minute, respectively. Continuous infusion of unlabeled propionate into a mesenteric vein at 1 mmol/minute reduced the HER, yet this depression was greatest for re-B12 (0.74 vs. 0.63 for de-B12 and re-B12, respectively). Net hepatic uptake of propionate was increased (1145 +/- 100 vs. 985 +/- 95 mumol/minute, respectively), although vitamin B-12 status was without effect. It is concluded that the ability of liver to extract propionate is not affected at vitamin B-12 concentrations greater than 250 ng/g wet liver. However, when propionate entry rate was enhanced by intramesenteric infusion, the livers of de-B12 sheep had a greater capacity to remove propionate suggesting that alternate routes of metabolism may occur.
Palavras-Chave:  Infusion; Nutritional disorders.
Thesaurus Nal:  Animal diseases; Animal feeding; Deficiency diseases; Liver; Metabolism; Parenteral feeding; Propionates; Propionic acid; Sheep; Vitamin B12.
Categoria do assunto:  L Ciência Animal e Produtos de Origem Animal
Marc:  Mostrar Marc Completo
Registro original:  Embrapa Caprinos e Ovinos (CNPC)
Biblioteca ID Origem Tipo/Formato Classificação Cutter Registro Volume Status URL
CNPC34040 - 1ADDAP - PP
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