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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
13/02/2017 |
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Data da última atualização: |
30/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CARDOSO, R. C.; ALVES, B. R. C.; SHARPTON, S. M.; WILLIAMS, G. L.; AMSTALDEN, M. |
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Afiliação: |
R. C. CARDOSO, Texas A&M University, College Station, TX, USA; BRUNA RIOS COELHO ALVES, CNPGL; S. M. SHARPTON, Texas A&M University, College Station, TX, USA; G. L. WILLIAMS, Texas A&M University, College Station, TX, USA; M. AMSTALDEN, Texas A&M University, College Station, TX, USA. |
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Título: |
Nutritional Programming of Accelerated Puberty in Heifers: Involvement of Pro-Opiomelanocortin Neurones in the Arcuate Nucleus. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
Journal of Neuroendocrinology, n. 27, p. 647-657, 2015. |
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Idioma: |
Inglês |
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Conteúdo: |
The timing of puberty and subsequent fertility in female mammals are dependent on the inte-gration of metabolic signals by the hypothalamus. Pro-opiomelanocortin (POMC) neurones inthe arcuate nucleus (ARC) comprise a critical metabolic-sensing pathway controlling the reproductive neuroendocrine axis. a-Melanocyte-stimulating hormone (aMSH), a product of thePOMC gene, has excitatory effects on gonadotrophin-releasing hormone (GnRH) neurones andfibres containing aMSH project to GnRH and kisspeptin neurones. Because kisspeptin is a potentstimulator of GnRH release, aMSH may also stimulate GnRH secretion indirectly via kisspeptinneurones. In the present work, we report studies conducted in young female cattle (heifers) aiming to determine whether increased nutrient intake during the juvenile period (4-8 months ofage), a strategy previously shown to advance puberty, alters POMC and KISS1 mRNA expression, as well as aMSH close contacts on GnRH and kisspeptin neurones. In Experiment 1, POMCmRNA expression, detected by in situ hybridisation, was greater (P < 0.05) in the ARC in heifersthat gained 1 kg/day of body weight (high-gain, HG; n = 6) compared to heifers that gained0.5 kg/day (low-gain, LG; n = 5). The number of KISS1-expressing cells in the middle ARC was reduced (P < 0.05) in HG compared to LG heifers. In Experiment 2, double-immunofluorescence showed limited aMSH-positive close contacts on GnRH neurones, and the magnitude of these inputs was not influenced by nutritional status. Conversely, a large number of kisspeptin-immu-noreactive cells in the ARC were observed in close proximity to aMSH-containing varicosities. Furthermore, HG heifers (n = 5) exhibited a greater (P < 0.05) percentage of kisspeptin neuronesin direct apposition to aMSH fibres and an increased (P < 0.05) number of aMSH close contactsper kisspeptin cell compared to LG heifers (n = 6). These results indicate that the POMC-kisspeptin pathway may be important in mediating the nutritional acceleration of puberty inheifers. MenosThe timing of puberty and subsequent fertility in female mammals are dependent on the inte-gration of metabolic signals by the hypothalamus. Pro-opiomelanocortin (POMC) neurones inthe arcuate nucleus (ARC) comprise a critical metabolic-sensing pathway controlling the reproductive neuroendocrine axis. a-Melanocyte-stimulating hormone (aMSH), a product of thePOMC gene, has excitatory effects on gonadotrophin-releasing hormone (GnRH) neurones andfibres containing aMSH project to GnRH and kisspeptin neurones. Because kisspeptin is a potentstimulator of GnRH release, aMSH may also stimulate GnRH secretion indirectly via kisspeptinneurones. In the present work, we report studies conducted in young female cattle (heifers) aiming to determine whether increased nutrient intake during the juvenile period (4-8 months ofage), a strategy previously shown to advance puberty, alters POMC and KISS1 mRNA expression, as well as aMSH close contacts on GnRH and kisspeptin neurones. In Experiment 1, POMCmRNA expression, detected by in situ hybridisation, was greater (P < 0.05) in the ARC in heifersthat gained 1 kg/day of body weight (high-gain, HG; n = 6) compared to heifers that gained0.5 kg/day (low-gain, LG; n = 5). The number of KISS1-expressing cells in the middle ARC was reduced (P < 0.05) in HG compared to LG heifers. In Experiment 2, double-immunofluorescence showed limited aMSH-positive close contacts on GnRH neurones, and the magnitude of these inputs was not influenced by nutritional ... Mostrar Tudo |
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Palavras-Chave: |
Arcuate nucleus; Kisspeptin. |
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Thesaurus Nal: |
heifers; pro-opiomelanocortin; puberty. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
null
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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| Registros recuperados : 3 | |
| 1. |  | GARCIA, P. H. de M.; SILVA, D. F. da; SILVA, M. T. da; CARVALHO, A. P. V. de; CAVALCANTE, J. T.; SANTOS, E. L.; FERREIRA, P. V.; CAMARA, T. M. M. Avaliação do desempenho forrageiro de variedades de sorgo submetidas a dois espaçamentos entre linhas. In: CONGRESSO BRASILEIRO DE ZOOTECNIA, 27.; FÓRUM DE ENTIDADES DE ZOOTECNISTAS, 45.; FÓRUM DE COORDENADORES DE CURSOS DE ZOOTENCIA, 12.; SEMINÁRIO NACIONAL DE ENSINO EM ZOOTECNIA, 7.; REUNIÃO NACIONAL DE SINDICATO DE ZOOTECNIA, 5.; FÓRUM DE EMPRESAS JUNIORES DE ZOOTECNIA, 5.; FÓRUM DE ESTUDANTES DE ZOOTECNIA, 13, 2017, Santos. Santos: Associação Brasileira de Zootecnia, 2017.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| 2. | | SILVA, D. F. da; GARCIA, P. H. de M.; CAVALCANTE, J. T.; FERREIRA, P. V.; SAMPAIO, L. V. A.; SILVA, A. J. A. C.; SILVA, M. T. da; SILVA NETO, J. V. da; NASCIMENTO, M. da S.; COSTA, L. M. da S.; SILVA, C. J. C. da; CAMARA, T. M. M. Avaliação biométrica de caracteres morfológicos de genótipos de milho e sorgo submetidos a duas densidades de semeadura. In: CONGRESSO ACADÊMICO INTEGRADO DE INOVAÇÃO E TECNOLOGIA, 1., 2016, Alagoas. Anais... Alagoas: UFAL, 2016. Resumo.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| 3. | | SILVA, D. F. da; GARCIA, P. H. de M.; CAVALCANTE, J. T.; FERREIRA, P. V.; SAMPAIO, L. V. A.; CAMARA, T. M. M.; SILVA, M. T. da; SILVA NETO, J. V. da; NASCIMENTO, M. da S.; COSTA, L. M. da S.; SILVA, J. A. C.; SANTOS, D. F. dos; SANTOS FILHO, A. M. dos. Desempenho de Genótipos de milho e sorgo sob diferentes densidades de plantio para produção de forragem. In: CONGRESSO ACADÊMICO INTEGRADO DE INOVAÇÃO E TECNOLOGIA, 1., 2016, Alagoas. Anais... Alagoas: UFAL, 2016. Resumo.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| Registros recuperados : 3 | |
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