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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Instrumentação. |
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Data corrente: |
06/12/2016 |
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Data da última atualização: |
30/07/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MUNK, M.; CAMARGO, L. S. A.; QUINTAO, C. C. R.; SILVA, S. R.; SOUZA, E. D.; RAPOSO, N. R. B.; MARCONCINI, J. M.; JORIO, A.; LADEIRA, L. O.; BRANDAO, H. M. |
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Afiliação: |
JOSE MANOEL MARCONCINI, CNPDIA. |
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Título: |
Biocompatibility assessment of fibrous nanomaterials in mammalian embryos. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Nanomedicine: nanotechnology, biology, and medicine, [S. l.], v. 12, p. 1151-1159, 2016. |
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DOI: |
10.1016/j.nano.2016.01.006 |
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Idioma: |
Inglês |
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Conteúdo: |
Currently there is a growing interest in the use of nanotechnology in reproductive medicine and reproductive biology. However, their toxic effects on mammalian embryos remain poorly understood. In this work, we evaluate the biocompatibility of two fibrous nanomaterials (NMs): cotton cellulose nanofibers (CNF) and carboxylated multiwalled carbon nanotubes (MWCNT-COOH), by performing an investigation of the embryonic development, gene expression (biomarkers focused on cell stress, apoptosis and totipotency) and in situ apoptosis in bovine embryos. Exposure to NMs did not interfere in preimplantation development or in the incidence of apoptosis in the bovine embryo, but they did affect the gene expression. The results presented are important for an understanding of the toxicity of cotton CNF and MWCNT-COOH on mammalian embryos. To our knowledge, we report the first evaluation of biocompatibility between these NMs on preimplantation embryos, which may open a new window for reproductive biomedical applications. |
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Palavras-Chave: |
Fibras; Fibrous nanomaterials; Nanomateriais. |
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Thesaurus Nal: |
apoptosis; biocompatibility; gene expression. |
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Categoria do assunto: |
--
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 01936naa a2200313 a 4500
001 2058034
005 2018-07-30
008 2016 bl uuuu u00u1 u #d
024 7 $a10.1016/j.nano.2016.01.006$2DOI
100 1 $aMUNK, M.
245 $aBiocompatibility assessment of fibrous nanomaterials in mammalian embryos.$h[electronic resource]
260 $c2016
520 $aCurrently there is a growing interest in the use of nanotechnology in reproductive medicine and reproductive biology. However, their toxic effects on mammalian embryos remain poorly understood. In this work, we evaluate the biocompatibility of two fibrous nanomaterials (NMs): cotton cellulose nanofibers (CNF) and carboxylated multiwalled carbon nanotubes (MWCNT-COOH), by performing an investigation of the embryonic development, gene expression (biomarkers focused on cell stress, apoptosis and totipotency) and in situ apoptosis in bovine embryos. Exposure to NMs did not interfere in preimplantation development or in the incidence of apoptosis in the bovine embryo, but they did affect the gene expression. The results presented are important for an understanding of the toxicity of cotton CNF and MWCNT-COOH on mammalian embryos. To our knowledge, we report the first evaluation of biocompatibility between these NMs on preimplantation embryos, which may open a new window for reproductive biomedical applications.
650 $aapoptosis
650 $abiocompatibility
650 $agene expression
653 $aFibras
653 $aFibrous nanomaterials
653 $aNanomateriais
700 1 $aCAMARGO, L. S. A.
700 1 $aQUINTAO, C. C. R.
700 1 $aSILVA, S. R.
700 1 $aSOUZA, E. D.
700 1 $aRAPOSO, N. R. B.
700 1 $aMARCONCINI, J. M.
700 1 $aJORIO, A.
700 1 $aLADEIRA, L. O.
700 1 $aBRANDAO, H. M.
773 $tNanomedicine: nanotechnology, biology, and medicine, [S. l.]$gv. 12, p. 1151-1159, 2016.
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Embrapa Instrumentação (CNPDIA) |
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| 1. |  | KIDO, E. A.; PANDOLFI, V.; FERREIRA NETO, J. R. C.; BARBOSA, P. D. de A.; ANDRADE, P. P. de; LANE, R.; GUIMARÃES, F. C. M.; ABDELNOOR, R. V.; BENKO-ISEPPON, A. M. Differential transcriptional profiling of phakopsora pachyrhizi-infected soybean revealed by high-throughput supersage. In: WORLD SOYBEAN RESEARCH CONFERENCE, 9., 2013, Durban. [Proceedings...]. Durban: OPDT: OPOT, 2013. Abst. 387. 1 CD-ROM. WSRC.| Tipo: Resumo em Anais de Congresso |
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