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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
30/08/2016 |
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Data da última atualização: |
03/10/2016 |
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Autoria: |
LANIGAN, G. W.; PAYNE, A. L.; PETERSON, J. E. |
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Título: |
Anti methanogenic drugs and heliotropium europaeum poisoning in penned sheep. |
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Ano de publicação: |
1978 |
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Fonte/Imprenta: |
Australian Journal of Agricultural Research, v. 29, n. 6, p. 1281-1292, 1978. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Most sheep fed for prolonged periods on a ration containing 50% dried H. europaeum developed some of the clinical manifestations seen in field cases of pyrrolizidine alkaloidosis. Histologically demonstrated liver damage in the laboratory animals was comparatively mild, but the marked decline in their bromosulphophthalein (BSP) clearance rates indicated severe depletion of liver functional capacity. In sheep fed on H. europaeum for 13 wk periods separated by 18 wk rests, simultaneous oral administration of iodoform (16 mg twice daily) led to an increase from 33-55 wk in the time required for death of half the susceptible sheep. Iodoform at levels of 32 mg and above twice daily proved hepatotoxic when given orally for several months. All susceptible sheep not given iodoform died following 2 periods of H. europaeum feeding, while 3 such periods were needed for iodoform-treated animals. Iodoform prophylaxis may be a useful protective measure in the field for sheep exposed to H. europaeum grazing during a single season. Up to 20% of the sheep used survived ingestion of H. europaeum for the full experimental term and some sustained little or no decline in BSP clearance rate. There are prospects for development of a pyrrolizidine-tolerant strain of sheep by selective breeding. Chloral hydrate proved unsatisfactory as a replacment for iodoform. |
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Thesagro: |
Ovino; Planta tóxica; Toxidez. |
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Thesaurus Nal: |
Chronic toxicity; Heliotropium; Pyrrolizidine alkaloids. |
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Categoria do assunto: |
K Ciência Florestal e Produtos de Origem Vegetal |
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Marc: |
LEADER 01988naa a2200217 a 4500
001 2052106
005 2016-10-03
008 1978 bl uuuu u00u1 u #d
100 1 $aLANIGAN, G. W.
245 $aAnti methanogenic drugs and heliotropium europaeum poisoning in penned sheep.
260 $c1978
520 $aAbstract: Most sheep fed for prolonged periods on a ration containing 50% dried H. europaeum developed some of the clinical manifestations seen in field cases of pyrrolizidine alkaloidosis. Histologically demonstrated liver damage in the laboratory animals was comparatively mild, but the marked decline in their bromosulphophthalein (BSP) clearance rates indicated severe depletion of liver functional capacity. In sheep fed on H. europaeum for 13 wk periods separated by 18 wk rests, simultaneous oral administration of iodoform (16 mg twice daily) led to an increase from 33-55 wk in the time required for death of half the susceptible sheep. Iodoform at levels of 32 mg and above twice daily proved hepatotoxic when given orally for several months. All susceptible sheep not given iodoform died following 2 periods of H. europaeum feeding, while 3 such periods were needed for iodoform-treated animals. Iodoform prophylaxis may be a useful protective measure in the field for sheep exposed to H. europaeum grazing during a single season. Up to 20% of the sheep used survived ingestion of H. europaeum for the full experimental term and some sustained little or no decline in BSP clearance rate. There are prospects for development of a pyrrolizidine-tolerant strain of sheep by selective breeding. Chloral hydrate proved unsatisfactory as a replacment for iodoform.
650 $aChronic toxicity
650 $aHeliotropium
650 $aPyrrolizidine alkaloids
650 $aOvino
650 $aPlanta tóxica
650 $aToxidez
700 1 $aPAYNE, A. L.
700 1 $aPETERSON, J. E.
773 $tAustralian Journal of Agricultural Research$gv. 29, n. 6, p. 1281-1292, 1978.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
