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Registro Completo |
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Biblioteca(s): |
Embrapa Arroz e Feijão. |
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Data corrente: |
15/04/2016 |
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Data da última atualização: |
15/04/2016 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ALVES, N. E. G.; VASCONCELOS, C. M.; BASSINELLO, P. Z.; MEJIA, E. G. de; MARTINO, H. S. D. |
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Afiliação: |
NATALIA ELIZABETH GALDINO ALVES, UFV; CHRISTIANE MILEIB VASCONCELOS, UNIVERSIDADE FEDERAL DE OURO PRETO; PRISCILA ZACZUK BASSINELLO, CNPAF; ELVIRA GONZALEZ DE MEJIA, UNIVERSITY OF ILLINOIS URBANA, Champaign; HERCIA STAMPINI DUARTE MARTINO, UFV. |
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Título: |
Digested protein isolate from fresh and stored Carioca beans reduced markers of atherosclerosis in oxidized LDL-induced THP-1 macrophages. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Journal of Functional Foods, v. 24, p. 97-111, 2016. |
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ISSN: |
1756-4646 |
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DOI: |
10.1016/j.jff.2016.03.027 |
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Idioma: |
Inglês |
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Conteúdo: |
Oxidized LDL (ox-LDL) and its interaction with lectin type ox-LDL receptor (LOX-1) determine atherosclerosis progression. The potential of peptides from digested protein isolate (DPI) derived from fresh and stored Carioca bean (Phaseolus vulgaris L.) to prevent ox-LDL induced inflammation in humanTHP-1 macrophage-like cells was examined here. BRS Pontal (PO) and BRSMG Madreperola (MP) fresh and stored for 6 months were cooked, and protein isolates were digested by pepsin?pancreatin. Peptides from stored Carioca beans decreased prostaglandin E-2 (PGE-2) (from 17.7 to 47%) and tumour necrosis factor-α (TNF-α) (12.3 to 82%). Stored MP (0.01 mg/mL) inhibited reactive oxygen species (ROS). LOX-1 and matrix metalloproteinase-9 (MMP-9) expression were reduced by peptides from all beans. Stored PO and MP digested protein isolates reduced expression of 10 cytokines related to atherosclerosis process. Peptides from Carioca beans presented anti-atherosclerotic properties comparable to simvastatin, which were related to inhibition of LOX-1, MMP-9 and ICAM-1. |
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Palavras-Chave: |
Bioactive peptides; Lectin type ox-LDL receptor 1; Oxidized LDL. |
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Thesagro: |
Feijão; Phaseolus vulgaris. |
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Categoria do assunto: |
Q Alimentos e Nutrição Humana |
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Marc: |
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001 2043480
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008 2016 bl uuuu u00u1 u #d
022 $a1756-4646
024 7 $a10.1016/j.jff.2016.03.027$2DOI
100 1 $aALVES, N. E. G.
245 $aDigested protein isolate from fresh and stored Carioca beans reduced markers of atherosclerosis in oxidized LDL-induced THP-1 macrophages.$h[electronic resource]
260 $c2016
520 $aOxidized LDL (ox-LDL) and its interaction with lectin type ox-LDL receptor (LOX-1) determine atherosclerosis progression. The potential of peptides from digested protein isolate (DPI) derived from fresh and stored Carioca bean (Phaseolus vulgaris L.) to prevent ox-LDL induced inflammation in humanTHP-1 macrophage-like cells was examined here. BRS Pontal (PO) and BRSMG Madreperola (MP) fresh and stored for 6 months were cooked, and protein isolates were digested by pepsin?pancreatin. Peptides from stored Carioca beans decreased prostaglandin E-2 (PGE-2) (from 17.7 to 47%) and tumour necrosis factor-α (TNF-α) (12.3 to 82%). Stored MP (0.01 mg/mL) inhibited reactive oxygen species (ROS). LOX-1 and matrix metalloproteinase-9 (MMP-9) expression were reduced by peptides from all beans. Stored PO and MP digested protein isolates reduced expression of 10 cytokines related to atherosclerosis process. Peptides from Carioca beans presented anti-atherosclerotic properties comparable to simvastatin, which were related to inhibition of LOX-1, MMP-9 and ICAM-1.
650 $aFeijão
650 $aPhaseolus vulgaris
653 $aBioactive peptides
653 $aLectin type ox-LDL receptor 1
653 $aOxidized LDL
700 1 $aVASCONCELOS, C. M.
700 1 $aBASSINELLO, P. Z.
700 1 $aMEJIA, E. G. de
700 1 $aMARTINO, H. S. D.
773 $tJournal of Functional Foods$gv. 24, p. 97-111, 2016.
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Registro original: |
Embrapa Arroz e Feijão (CNPAF) |
