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Registro Completo |
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Biblioteca(s): |
Embrapa Agroenergia. |
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Data corrente: |
01/10/2015 |
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Data da última atualização: |
20/09/2017 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
NISHIJIMA, C. M.; DELELLA, F. K.; RODRIGUES, C. M.; RINALDO, D.; LOPES-FERREIRA, M. V. dos Anjos; ROCHA, L. R. M. da; VILEGAS, W.; FELISBINO, S. L.; HIRUMA-LIMA, C. A. |
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Afiliação: |
Catarine Massucato Nishijima, UNESP; Flavia Karina Delella, UNESP; CLENILSON MARTINS RODRIGUES, CNPAE; Daniel Rinaldo, UNESP; Monica Valdyrce dos Anjos Lopes-Ferreira, Instituto Butantan; Lucia Regina Machado da Rocha, UNESP; Wagner Vilegas, UNESP; Sergio Luis Felisbino, UNESP; Clélia Akiko Hiruma-Lima, UNESP. |
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Título: |
The anti-inflammatory effects of the methanolic extract and fractions from Davilla elliptica St Hil (Dilleniaceae) on Bothrops jararaca envenomation. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
International Journal of Molecular Sciences, v. 16, n. 6, 2015 |
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DOI: |
10.3390/ijms160612454 |
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Idioma: |
Inglês |
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Conteúdo: |
Inflammation and haemorrhage are the main characteristics of tissue injury in botropic envenomation. Although some studies have shown that anti-venom prevents systemic reactions, it is not efficient in preventing tissue injury at the site of the bite. Therefore, this work was undertaken to investigate the anti-inflammatory effects of the methanolic extract and fractions from D. elliptica and to evaluate the role of matrix metalloproteinases (MMPs) in this process. Effects of the extract and fractions from D. elliptica were evaluated using a carrageenan-induced paw oedema model in rats, and leukocyte rolling was visualized by intravital. The quantification of MMPs activities (MMP-2 and MMP-9) extracted from the dermis of mice treated with extract and fractions alone or incubated with venom was determined by zymographic analyses. Our results show that intraperitoneal (i.p.) injection of fractions significantly reduced paw oedema after the carrageenan challenge. Treatment with the tannins fraction also resulted in considerable inhibition of the rolling of leukocytes and this fraction was able to decrease the activation of MMP-9. These results confirmed the anti-inflammatory activity of the methanolic extract and tannins fraction of D. elliptica and showed that the dermonecrosis properties of B. jararaca venom might be mediated through the inhibition of MMP-9 activity. |
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Palavras-Chave: |
Anti-inflammatory effect; Bothrops jararaca venom; Davilla elliptica St Hil; Efeito antiinflamatório; MMP-9; MP-2; Veneno Bothrops jararaca. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02409naa a2200313 a 4500
001 2025612
005 2017-09-20
008 2015 bl uuuu u00u1 u #d
024 7 $a10.3390/ijms160612454$2DOI
100 1 $aNISHIJIMA, C. M.
245 $aThe anti-inflammatory effects of the methanolic extract and fractions from Davilla elliptica St Hil (Dilleniaceae) on Bothrops jararaca envenomation.$h[electronic resource]
260 $c2015
520 $aInflammation and haemorrhage are the main characteristics of tissue injury in botropic envenomation. Although some studies have shown that anti-venom prevents systemic reactions, it is not efficient in preventing tissue injury at the site of the bite. Therefore, this work was undertaken to investigate the anti-inflammatory effects of the methanolic extract and fractions from D. elliptica and to evaluate the role of matrix metalloproteinases (MMPs) in this process. Effects of the extract and fractions from D. elliptica were evaluated using a carrageenan-induced paw oedema model in rats, and leukocyte rolling was visualized by intravital. The quantification of MMPs activities (MMP-2 and MMP-9) extracted from the dermis of mice treated with extract and fractions alone or incubated with venom was determined by zymographic analyses. Our results show that intraperitoneal (i.p.) injection of fractions significantly reduced paw oedema after the carrageenan challenge. Treatment with the tannins fraction also resulted in considerable inhibition of the rolling of leukocytes and this fraction was able to decrease the activation of MMP-9. These results confirmed the anti-inflammatory activity of the methanolic extract and tannins fraction of D. elliptica and showed that the dermonecrosis properties of B. jararaca venom might be mediated through the inhibition of MMP-9 activity.
653 $aAnti-inflammatory effect
653 $aBothrops jararaca venom
653 $aDavilla elliptica St Hil
653 $aEfeito antiinflamatório
653 $aMMP-9
653 $aMP-2
653 $aVeneno Bothrops jararaca
700 1 $aDELELLA, F. K.
700 1 $aRODRIGUES, C. M.
700 1 $aRINALDO, D.
700 1 $aLOPES-FERREIRA, M. V. dos Anjos
700 1 $aROCHA, L. R. M. da
700 1 $aVILEGAS, W.
700 1 $aFELISBINO, S. L.
700 1 $aHIRUMA-LIMA, C. A.
773 $tInternational Journal of Molecular Sciences$gv. 16, n. 6, 2015
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