Data/hora: 19/04/2024 20:46:09

Biblioteca(s): 	Embrapa Agroindústria Tropical; Embrapa Pecuária Sudeste; Embrapa Pecuária Sul.	
Data corrente: 	09/05/2019	
Data da última atualização: 	17/02/2020	
Autoria: 	SOARES, S. M.; DOMINGUES, R.; GASPAR, E. B.; SANTOS, P. A. dos; CANUTO, K. M.; MINHO, A. P.; VIEIRA, M. I. B.	
Afiliação: 	SUELEN MENDONÇA SOARES, UPF; ROBERT DOMINGUES, CPPSUL; EMANUELLE BALDO GASPAR, CPPSUL; PATRÍCIO AZEVEDO DOS SANTOS, URCAMP; KIRLEY MARQUES CANUTO, CNPAT; ALESSANDRO PELEGRINE MINHO, CPPSE; MARIA ISABEL BOTELHO VIEIRA, UPF.	
Título: 	In vitro ovicidal effect of a Senecio brasiliensis extract and its fractions on Haemonchus contortus.	
Ano de publicação: 	2019	
Fonte/Imprenta: 	BMC Veterinary Research, v. 15, n. 99, 25 Mar. 2019.	
Páginas: 	9 p.	
DOI: 	10.1186/s12917-019-1843-7	
Idioma: 	Inglês	
Conteúdo: 	Background: Haemonchosis affects sheep husbandry and its treatment is often compromised due to the development of anthelminthic resistance. Plant-derived bioactive compounds have been studied as alternative to control Haemonchus contortus. The objective of this study was to evaluate the effect of Senecio brasiliensis extracts on H. contortus egg hatching and infective larvae migration. Results: The aqueous extract from dried and fresh plant and alkaloid-enriched fraction of the previously dried leaves of S. brasiliensis inhibited H. contortus egg hatching. The main plant compound in alkaloid fraction was integerrimine, a pyrrolizidine alkaloid (PA). However, the aqueous extract from dried plant displayed higher efficacy when compared to their alkaloid enriched or non-polar fractions, meaning that, although PAs contributed to the ovicidal effect, other compounds in the plant can also contribute to their effect. Furthermore, the aqueous extract from dried plant also had higher efficacy than aqueous extract from fresh plant in larvae migration inhibition. Finally, extract from dried plant presented low in vitro cytotoxic effect. Conclusion: Taken together our results suggest a good anthelmintic effect of S. brasiliensis, especially when aqueous extract is prepared from dried plant. Further in vivo studies should be performed focused on forms of administration of this extract in rearing sheep.	
Palavras-Chave: 	Alcalóides de pirrolizidina; Antelmíntico; Egg hatching; Incubação de ovos; Infective larvae migration; Migração de larvas infectantes; Pequenos ruminantes.	
Thesagro: 	Anti-Helmíntico; Extrato Vegetal; Incubação Artificial; Maria Mole; Nematóide; Planta Tóxica.	
Thesaurus Nal: 	Plant extracts; Pyrrolizidine alkaloids; Small ruminants.	
Categoria do assunto: 	--	
URL: 	http://ainfo.cnptia.embrapa.br/digital/bitstream/item/197181/1/In-vitro-ovicidal-effect-Senecio.pdf
http://ainfo.cnptia.embrapa.br/digital/bitstream/item/208998/1/ART19126.pdf	
Registro original: 	Embrapa Pecuária Sul (CPPSUL)	
Exemplares: 	CPPSUL - (14541-1) - UPC - AP - DD -  -  -  - DIS
CPPSE - (24778-1) - UPC - AP - DD - PROCI-2019.00022 - SOA - 2019.00028 - DIS
CNPAT - (16362-1) - UPC - AP - DD -  -  -  - DIS