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 | Acesso ao texto completo restrito à biblioteca da Embrapa Meio Ambiente. Para informações adicionais entre em contato com cnpma.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
31/10/2014 |
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Data da última atualização: |
31/10/2014 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CLEMENTE, Z.; CASTRO, V. L. S. S. de; MOURA, M. A. M.; JONSSON, C. M.; FRACETO, L. F. |
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Afiliação: |
ZAIRA CLEMENTE, IB-UNICAMP; VERA LUCIA SCHERHOLZ S DE CASTRO, CNPMA; MONICA ACAUI MARCONDES DE MOURA, IB-APTA; CLAUDIO MARTIN JONSSON, CNPMA; LEONARDO FERNANDES FRACETO, UNESP. |
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Título: |
Toxicity assessment of TiO2 nanoparticles in zebrafish embryos under different exposure conditions. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
Aquatic Toxicology, Amsterdam, v. 147, p. 129-139, 2014. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The popularity of TiO2 nanoparticles (nano-TiO2) lies in their wide range of nanotechnological applications, together with low toxicity. Meanwhile, recent studies have shown that the photocatalytic properties of this material can result in alterations in their behavior in the environment, causing effects that have not yet been fully elucidated. The objective of this study was to evaluate the toxicity of two formulations of nano-TiO2 under different illumination conditions, using an experimental model coherent with the principle of the three Rs of alternative animal experimentation (reduction, refinement, and replacement). Embryos of the fish Danio rerio were exposed for 96 h to different concentrations of nano-TiO2 in the form of anatase (TA) or an anatase/rutile mixture (TM), under either visible light or a combination of visible and ultraviolet light (UV). The acute toxicity and sublethal parameters evaluated included survival rates, malformation, hatching, equilibrium, and overall length of the larvae, together with biochemical biomarkers (specific activities of catalase (CAT), glutathione S-transferase (GST), and acid phosphatase (AP)). Both TA and TM caused accelerated hatching of the larvae. Under UV irradiation, there was greater mortality of the larvae of the groups exposed to TM, compared to those exposed to TA. Exposure to TM under UV irradiation altered the equilibrium of the larvae. Alterations in the activities of CAT and GST were indicative of oxidative stress, although no clear dose-response relationship was observed. The effects of nano-TiO2 appeared to depend on both the type of formulation and the illumination condition. The findings contribute to elucidation of the factors involved in the toxicity of these nanoparticles, as well as to the establishment of protocols for risk assessments of nanotechnology. MenosAbstract: The popularity of TiO2 nanoparticles (nano-TiO2) lies in their wide range of nanotechnological applications, together with low toxicity. Meanwhile, recent studies have shown that the photocatalytic properties of this material can result in alterations in their behavior in the environment, causing effects that have not yet been fully elucidated. The objective of this study was to evaluate the toxicity of two formulations of nano-TiO2 under different illumination conditions, using an experimental model coherent with the principle of the three Rs of alternative animal experimentation (reduction, refinement, and replacement). Embryos of the fish Danio rerio were exposed for 96 h to different concentrations of nano-TiO2 in the form of anatase (TA) or an anatase/rutile mixture (TM), under either visible light or a combination of visible and ultraviolet light (UV). The acute toxicity and sublethal parameters evaluated included survival rates, malformation, hatching, equilibrium, and overall length of the larvae, together with biochemical biomarkers (specific activities of catalase (CAT), glutathione S-transferase (GST), and acid phosphatase (AP)). Both TA and TM caused accelerated hatching of the larvae. Under UV irradiation, there was greater mortality of the larvae of the groups exposed to TM, compared to those exposed to TA. Exposure to TM under UV irradiation altered the equilibrium of the larvae. Alterations in the activities of CAT and GST were indicative of oxidati... Mostrar Tudo |
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Palavras-Chave: |
Biomarker; Dióxido de titânio; FET; Fish Embryo Test; Nanoecotoxicologia; Nanotoxicology. |
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Thesagro: |
Peixe de água doce; Raio ultravioleta; Toxidez. |
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Thesaurus Nal: |
Danio rerio; Ecotoxicology; Nanoparticles; Nanotechnology; oxidative stress; Toxicity; Ultraviolet radiation. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02889naa a2200361 a 4500
001 1998932
005 2014-10-31
008 2014 bl uuuu u00u1 u #d
100 1 $aCLEMENTE, Z.
245 $aToxicity assessment of TiO2 nanoparticles in zebrafish embryos under different exposure conditions.$h[electronic resource]
260 $c2014
520 $aAbstract: The popularity of TiO2 nanoparticles (nano-TiO2) lies in their wide range of nanotechnological applications, together with low toxicity. Meanwhile, recent studies have shown that the photocatalytic properties of this material can result in alterations in their behavior in the environment, causing effects that have not yet been fully elucidated. The objective of this study was to evaluate the toxicity of two formulations of nano-TiO2 under different illumination conditions, using an experimental model coherent with the principle of the three Rs of alternative animal experimentation (reduction, refinement, and replacement). Embryos of the fish Danio rerio were exposed for 96 h to different concentrations of nano-TiO2 in the form of anatase (TA) or an anatase/rutile mixture (TM), under either visible light or a combination of visible and ultraviolet light (UV). The acute toxicity and sublethal parameters evaluated included survival rates, malformation, hatching, equilibrium, and overall length of the larvae, together with biochemical biomarkers (specific activities of catalase (CAT), glutathione S-transferase (GST), and acid phosphatase (AP)). Both TA and TM caused accelerated hatching of the larvae. Under UV irradiation, there was greater mortality of the larvae of the groups exposed to TM, compared to those exposed to TA. Exposure to TM under UV irradiation altered the equilibrium of the larvae. Alterations in the activities of CAT and GST were indicative of oxidative stress, although no clear dose-response relationship was observed. The effects of nano-TiO2 appeared to depend on both the type of formulation and the illumination condition. The findings contribute to elucidation of the factors involved in the toxicity of these nanoparticles, as well as to the establishment of protocols for risk assessments of nanotechnology.
650 $aDanio rerio
650 $aEcotoxicology
650 $aNanoparticles
650 $aNanotechnology
650 $aoxidative stress
650 $aToxicity
650 $aUltraviolet radiation
650 $aPeixe de água doce
650 $aRaio ultravioleta
650 $aToxidez
653 $aBiomarker
653 $aDióxido de titânio
653 $aFET
653 $aFish Embryo Test
653 $aNanoecotoxicologia
653 $aNanotoxicology
700 1 $aCASTRO, V. L. S. S. de
700 1 $aMOURA, M. A. M.
700 1 $aJONSSON, C. M.
700 1 $aFRACETO, L. F.
773 $tAquatic Toxicology, Amsterdam$gv. 147, p. 129-139, 2014.
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Embrapa Meio Ambiente (CNPMA) |
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| Registros recuperados : 9 | |
| 2. |  | GIGLIOTI, C.; GIGLIOTI, R.; SCHIAVONE, D.; CARVALHO, C. O. de; FERREZINI, J.; CHAGAS, A. C. de S.; ESTEVES, S. N.; OLIVEIRA, M. C. de S. Avaliação de vermifugação seletiva em ovelhas criadas na região de São Carlos, SP. In: SIMPÓSIO DE INICIAÇÃO CIENTÍFICA DA EMBRAPA PECUÁRIA SUDESTE, 2008, São Carlos, SP. Anais... São Carlos: Embrapa Pecuária Sudeste, 2008. p. 4. (Embrapa Pecuária Sudeste. Documentos, 79).| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 3. | | FERREIRA, M. das G. R.; COSTA, C. J.; PINHEIRO, C. U. B.; SOUZA, E. R. B. de; CARVALHO, C. O. de. Buriti. In: LOPES, R.; OLIVEIRA, M. do S. P. de; CAVALLARI, M. M.; BARBIERI, R. L.; CONCEIÇÃO, L. D. H. C. S. da. (Ed.). Palmeiras nativas do Brasil. Brasília, DF: Embrapa, 2015. p.155-180| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Maranhão. |
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| 4. | | FERREIRA, M. das G. R.; COSTA, C. J.; PINHEIRO, C. U. B.; SOUZA, E. R. B. de; CARVALHO, C. O. de. Mauritia flexuosa buriti. In: CORADIN, L.; CAMILLO, J.; PAREYN, F. G. C. (Ed.). Espécies nativas da flora brasileira de valor econômico atual ou potencial: plantas para o futuro: região Nordeste. Brasília, DF: MMA, 2018. p. 193-204. 11 p. (Série Biodiversidade, 51)| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Maranhão. |
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| 5. | | FERREIRA, M. das G. R.; COSTA, C. J.; PINHEIRO, C. U. B.; SOUZA, E. R. B. de; CARVALHO, C. O. de. Mauritia flexuosa: buriti. CORADIN, L.; CAMILLO, J.; VIEIRA, I. C. G. (ed.). Espécies nativas da flora brasileira de valor econômico atual ou potencial: plantas para o futuro: região Norte. Brasília, DF: MMA, 2022. 1452 p. (Série Biodiversidade, 53). p. 1215-1226. Cap. 5.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Hortaliças; Embrapa Maranhão. |
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| 6. | | CALA, A. C.; TONELOTTO, M.; CARVALHO, C. O. de; FREITAS, A. R. de; OLIVEIRA, M. C. de S.; CHAGAS, A. C. de S. Atividade ovicida e larvacida de isolados comerciais de plantas sobre nematóides gastrintestinais de ovinos. In: CONGRESSO BRASILEIRO DE PARASITOLOGIA 21.: ENCONTRO DE PARASITOLOGIA DO MERCOSUL, 2., 2009, Foz do Iguaçu. Foz do Iguaçu: SBP, 2009. p. 1343.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 7. | | SCHIAVONE, D.; GIGLIOTI, R.; CARVALHO, C. O. de; FERREZINI, J.; CHAGAS, A. C. de S.; ALENCAR, M. M. de; OLIVEIRA, M. C. de S. Avaliação da resistência de bovinos de diferentes grupos genéticos aos nematódeos gastrintestinais. In: SIMPÓSIO DE INICIAÇÃO CIENTÍFICA DA EMBRAPA PECUÁRIA SUDESTE, 2008, São Carlos, SP. Anais... São Carlos: Embrapa Pecuária Sudeste, 2008. p. 2 (Documentos / Embrapa Pecuária Sudeste; 79) Editado por Marco Aurélio C.M. Bergamaschi e Patricia Menezes Santos| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 8. | | FERREZINI, J.; SCHIAVONE, D.; CARVALHO, C. O. de; FREITAS, A. R. de; CHAGAS, A. C. de S.; OLIVEIRA, M. C. de S. Efeito acaricida in vitro do extrato bruto de sementes de Neem sobre Rhipicephalus microplus. In: SIMPÓSIO DE INICIAÇÃO CIENTÍFICA DA EMBRAPA PECUÁRIA SUDESTE, 2008, São Carlos, SP. Anais... São Carlos: Embrapa Pecuária Sudeste, 2008. p. 7. (Embrapa Pecuária Sudeste. Documentos, 79).| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 9. | | SILVEIRA, R. X.; CHAGAS, A. C. de S.; BOTURA, M. B.; BATATINHA, M. J. M.; CARVALHO, C. O. de; BEVILAQUA, C. M. L.; BRANCO, A.; MACHADO, E. de A. A.; BORGES, S. L.; ORNELAS-ALMEIDA, M. A. Influência do resíduo líquido do sisal (Agave sisalana, Perrine) sobre a eclosão de ovos e o desenvolvimento larvar, in vitre, de nematóides gastrintestinais de ovinos. In: CONGRESSO BRASILEIRO DE MEDICINA VETERINÁRIA, 36.; ENCONTRO BRASILEIRO DE MÉDICOS VETERINÁRIOS DAS FORÇAS ARMADAS; ENCONTRO DO COLÉGIO BRASILEIRO DE AQUICULTURA; ENCONTRO DE MEDICINA DE ANIMAIS AQUÁTICOS, 6.; ENCONTRO DOS MÉDICOS VETERINÁRIOS DA BAHIA, 68., 2009, PORTO SEGURO. INOVAÇÃO E RESPONSABILIDADE SOCIAL: anais. PORTO SEGURO: CONBRAVET, 2009. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| Registros recuperados : 9 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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