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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
03/09/2014 |
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Data da última atualização: |
28/03/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CHAGAS, A. C. de S.; DOMINGUES, L. F.; FANTATTO, R. R.; GIGLIOTI, R.; OLIVEIRA, M. C. de S.; OLIVEIRA, D. H.; MANO, R. A.; JACOB, R. G. |
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Afiliação: |
ANA CAROLINA DE SOUZA CHAGAS, CPPSE; LUCIANA F. DOMINGUES, PÓS GRADUAÇÃO UNESP/SÃO CARLOS, SP; RAFAELA R. FANTATTO, CENTRO UNIVERSITÁRIO CENTRAL PAULISTA/SÃO CARLOS, SP; RODRIGO GIGLIOTI, PÓS GRADUAÇÃO UNESP/JABOTICABAL; MARCIA CRISTINA DE SENA OLIVEIRA, CPPSE; DANIELA H. OLIVEIRA, UNIVERSIDADE FEDERAL DE PELOTAS/PELOTAS; RENATA A. MANO, UNIVERSIDADE FEDERAL DE PELOTAS/PELOTAS; RAQUEL G. JACOB, UNIVERSIDADE FEDERAL DE PELOTAS/PELOTAS. |
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Título: |
In vitro and in vivo acaricide action of juvenoid analogs produced from the chemical modification of Cymbopogon spp. and Corymbia citriodora essential oil on the cattle tick Rhipicephalus (Boophilus) microplus. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
Veterinary Parasitology, v. 205, n. 1-2, p. 277-284, sep. 2014. |
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DOI: |
https://doi.org/10.1016/j.vetpar.2014.06.030 |
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Idioma: |
Inglês |
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Conteúdo: |
The present study aimed to evaluate the acaricidal action of the chemically modified essential oil of Cymbopogon spp. and Corymbia citriodora on Rhipicephalus (Boophilus) microplus. Citronellal was converted into N-butylcitronellylamine and in N-prop-2-inylcitronellylamine, analogs of juvenoids, by reductive amination using butylamine (N1 to N3) and propargylamine (N4 to N7). In vitro assays included the adult immersion, and larval packet tests. Engorged females were weighed in groups of 10 and tested in three replicates for six concentrations. They were immersed in the modified oils or control solution and incubated. In the larval packet test, the same substances and concentrations were evaluated in three replicates. In the in vivo test, six pastured heifers naturally infested with R. (B.) microplus were used per treatment: negative control, positive control (amitraz, Triatox®), original oil of C. citriodora at 1.5%, and modified oil containing 0.9% N-prop-2-inylcitronellylamine (N7). Ticks were counted in the right side of the body in 24 animals from day D-3 to D21. LC50 and LC90 were obtained by Probit analysis, while the in vivo results were log transformed and compared using the Tukey test. Among the nitrocellylamines tested in vitro, N6 was most effective on the engorged females (100% efficacy at 50 mg/mL) and N7 on the larvae (100% efficacy at 6.25 mg/mL). In the test with larvae, the original oil of C. citriodora was less effective than the counterpart modified oil (N7), proving that the chemical modification optimized its effect. In the in vivo test, no significant difference was observed between N7 and the negative control. The average numbers of ticks on the animals? right side were 32.8, 8.1, 37.9 and 35.4 for the negative control, positive control, original oil and N7, respectively. The chemical modification improved the efficacy in vitro, but it was not observed in vivo, perhaps due to the low stability of the amines under field conditions. The evaluation carried out here has not been previously studied, so this concept expands the horizon for research into chemically modified substances for parasite control and shed light on the challenges to find effective formulations and application methods. MenosThe present study aimed to evaluate the acaricidal action of the chemically modified essential oil of Cymbopogon spp. and Corymbia citriodora on Rhipicephalus (Boophilus) microplus. Citronellal was converted into N-butylcitronellylamine and in N-prop-2-inylcitronellylamine, analogs of juvenoids, by reductive amination using butylamine (N1 to N3) and propargylamine (N4 to N7). In vitro assays included the adult immersion, and larval packet tests. Engorged females were weighed in groups of 10 and tested in three replicates for six concentrations. They were immersed in the modified oils or control solution and incubated. In the larval packet test, the same substances and concentrations were evaluated in three replicates. In the in vivo test, six pastured heifers naturally infested with R. (B.) microplus were used per treatment: negative control, positive control (amitraz, Triatox®), original oil of C. citriodora at 1.5%, and modified oil containing 0.9% N-prop-2-inylcitronellylamine (N7). Ticks were counted in the right side of the body in 24 animals from day D-3 to D21. LC50 and LC90 were obtained by Probit analysis, while the in vivo results were log transformed and compared using the Tukey test. Among the nitrocellylamines tested in vitro, N6 was most effective on the engorged females (100% efficacy at 50 mg/mL) and N7 on the larvae (100% efficacy at 6.25 mg/mL). In the test with larvae, the original oil of C. citriodora was less effective than the counterpart modified oil (... Mostrar Tudo |
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Palavras-Chave: |
Botanical acaricides; Citronellylamines; Juvenoids; Rhipicephalus (Boophilus) microplusa. |
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Thesaurus Nal: |
Citronellal; Phytotherapy. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 03269naa a2200289 a 4500
001 1994074
005 2023-03-28
008 2014 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.vetpar.2014.06.030$2DOI
100 1 $aCHAGAS, A. C. de S.
245 $aIn vitro and in vivo acaricide action of juvenoid analogs produced from the chemical modification of Cymbopogon spp. and Corymbia citriodora essential oil on the cattle tick Rhipicephalus (Boophilus) microplus.$h[electronic resource]
260 $c2014
520 $aThe present study aimed to evaluate the acaricidal action of the chemically modified essential oil of Cymbopogon spp. and Corymbia citriodora on Rhipicephalus (Boophilus) microplus. Citronellal was converted into N-butylcitronellylamine and in N-prop-2-inylcitronellylamine, analogs of juvenoids, by reductive amination using butylamine (N1 to N3) and propargylamine (N4 to N7). In vitro assays included the adult immersion, and larval packet tests. Engorged females were weighed in groups of 10 and tested in three replicates for six concentrations. They were immersed in the modified oils or control solution and incubated. In the larval packet test, the same substances and concentrations were evaluated in three replicates. In the in vivo test, six pastured heifers naturally infested with R. (B.) microplus were used per treatment: negative control, positive control (amitraz, Triatox®), original oil of C. citriodora at 1.5%, and modified oil containing 0.9% N-prop-2-inylcitronellylamine (N7). Ticks were counted in the right side of the body in 24 animals from day D-3 to D21. LC50 and LC90 were obtained by Probit analysis, while the in vivo results were log transformed and compared using the Tukey test. Among the nitrocellylamines tested in vitro, N6 was most effective on the engorged females (100% efficacy at 50 mg/mL) and N7 on the larvae (100% efficacy at 6.25 mg/mL). In the test with larvae, the original oil of C. citriodora was less effective than the counterpart modified oil (N7), proving that the chemical modification optimized its effect. In the in vivo test, no significant difference was observed between N7 and the negative control. The average numbers of ticks on the animals? right side were 32.8, 8.1, 37.9 and 35.4 for the negative control, positive control, original oil and N7, respectively. The chemical modification improved the efficacy in vitro, but it was not observed in vivo, perhaps due to the low stability of the amines under field conditions. The evaluation carried out here has not been previously studied, so this concept expands the horizon for research into chemically modified substances for parasite control and shed light on the challenges to find effective formulations and application methods.
650 $aCitronellal
650 $aPhytotherapy
653 $aBotanical acaricides
653 $aCitronellylamines
653 $aJuvenoids
653 $aRhipicephalus (Boophilus) microplusa
700 1 $aDOMINGUES, L. F.
700 1 $aFANTATTO, R. R.
700 1 $aGIGLIOTI, R.
700 1 $aOLIVEIRA, M. C. de S.
700 1 $aOLIVEIRA, D. H.
700 1 $aMANO, R. A.
700 1 $aJACOB, R. G.
773 $tVeterinary Parasitology$gv. 205, n. 1-2, p. 277-284, sep. 2014.
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Embrapa Pecuária Sudeste (CPPSE) |
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| 3. |  | FERNANDO, F. S.; OKINO, C. H.; SILVA, K. R.; FERNANDES, C. C.; GONÇALVES, M. C. M.; MONTASSIER, M. F. S.; VASCONCELOS, R. O.; MONTASSIER, H. J. Increased expression of Interleukin-6 related to nephritis in chickens challenged with an Avian infectious bronchitis virus variant. Pesquisa Veterinária Brasileira, Brasília, DF, v. 35, n. 3, p. 216-222, mar. 2015.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 4. | | FERNANDES, C. C.; SMITH, G. T.; PODOS, J.; NOGUEIRA, A.; INOUE, L. A. K. A.; AKAMA, A.; HO, W. W.; ALVES-GOMES, J. Hormonal and behavioral correlates of morphological variation in an Amazonian electric fish (Sternarchogiton nattereri: Apteronotidae). Hormones and Behavior 58, n. 4, p. 660-668, 2010.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 5. | | FERNANDES, C. C.; SMITH, G. T.; PODOS, J.; NOGUEIRA, A.; INOUE, L. A. K. A.; AKAMA, A.; HO, W. W.; GOMES, J. A. Correlação hormonal e comportamental da variação morfológica em um peixe elétrico da Amazônia (Sternarchogiton nattereri). In: ENCONTRO BRASILEIRO DE ICTIOLOGIA, 19., 2011, Manaus. Livro de programação e resumos. Manaus: INPA, AIHA, SBI, 2011. 1 CD-ROM. p. 605.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 6. | | JAKOVAC, C. C.; NASCIMENTO, N.; GALLEGOS, S. C.; CELENTANO, D.; VIEIRA, D. L. M.; FERNANDES, C. C.; BRIENZA JUNIOR, S.; PELLICCIOTTI, A. S. Estratégias para implementar a restauração florestal em grande escala na Amazônia. In: SCIENCE PANEL FOR THE AMAZON, New York, 2024. [Publicações...]. New York: SPA Technical Secretariat, 2024. 16 p. Policy brief.| Tipo: Nota Técnica/Nota Científica |
| Biblioteca(s): Embrapa Florestas; Embrapa Recursos Genéticos e Biotecnologia. |
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| 7. | | ARAÚJO, F. C.; LIMA, P. S. da C.; SOUZA, H. A. de; ARAUJO NETO, R. B. de; FUNNICELLI, M. I. G.; FERNANDES, C. C. Diversidade da microbiota do solo em sistemas integrados de produção em áreas do Cerrado maranhense. In: JORNADA DE INICIAÇÃO CIENTÍFICA DA EMBRAPA MEIO-NORTE, 9., 2023, Teresina, PI. Anais... Teresina: Embrapa Meio-Norte, 2024. p. 60. (Embrapa Meio-Norte. Eventos técnicos & científicos, 1).| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Meio-Norte. |
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| 8. | | SILVA, L. M.; OLIVEIRA, C. H. de A.; SILVA, C. M. G da; SILVA, A. M.; FERNANDES, C. C. L.; FURTADO, R. F.; PINHEIRO, D. C. S. N.; GUEDES, M. I. F.; RONDINA, D. Uso de farelo de mamona (Ricinus communis L.) como fonte de proteína na dieta de caprinos durante o período de monta: impacto sobre a resposta reprodutiva e metabólica. Semina: Ciências Agrárias, Londrina, v. 36, n. 1, p. 203-216, 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
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