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Registro Completo |
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Biblioteca(s): |
Embrapa Cerrados; Embrapa Suínos e Aves. |
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Data corrente: |
29/08/2013 |
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Data da última atualização: |
25/11/2013 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
OKINO, C. H.; ALESSI, A. C.; MONTASSIER, M. de F. S.; ROSA, A. J. de M.; WANG, X.; MONTASSIER, H. J. |
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Afiliação: |
CINTIA HIROMI OKINO, CNPSA; ANTONIO CARLOS ALESSI; MARIA DE FÁTIMA SILVA MONTASSIER; ARTUR JORDAO DE MAGALHAES ROSA, CPAC; XIUQING WANG; HÉLIO JOSÉ MONTASSIER. |
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Título: |
Humoral and Cell-Mediated Immune Responses to Different Doses of Attenuated Vaccine Against Avian Infectious Bronchitis Virus. |
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Ano de publicação: |
2013 |
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Fonte/Imprenta: |
Viral Immunology, Nova York, v. 26, n. 4, p. 1-9, 2013. |
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DOI: |
10.1089/vim.2013.0015 |
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Idioma: |
Inglês |
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Conteúdo: |
The antibody and cellular immune responses against infectious bronchitis virus (IBV) were evaluated at mucosal sites of chickens after immunization with various doses of an attenuated vaccine at 1 day of age. The correlation of these immune responses with protection of tracheal tissues was evaluated after experimental infection of these birds. Significantly reduced tracheal pathologic effects, measured according to ciliostasis and histology lesions, and reduced viral load were observed only in the full-dose vaccinated group at 5 days post-infection (dpi), while incomplete protection was observed for the subdose vaccinated groups. Moreover, birds of vaccinated groups, especially with full dose, developed higher levels of lachrymal IBV-specific IgG and IgA and increased the expression of cell-mediated immunity (CMI) genes, such as gamma interferon (IFN gamma), CD8+ T cell marker, and granzyme homolog A more rapidly. In addition, these humoral and cellular immune responses evaluated at mucosal sites correlated significantly with tracheal protection against homologous IBV challenge in a vaccine dose-dependent manner. The results indicate that IgG, IgA and CD8+ T cell responses developed at mucosal sites after IBV vaccination of day-old chicks, could be taken as good correlates of protection against this virus. (AU) |
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Palavras-Chave: |
Bronquite infecciosa aviária. |
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Thesagro: |
Imunologia; Vacina; Virologia; Vírus. |
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Thesaurus Nal: |
Aviculture; Immune response; Infectious Bronchitis; Vaccination. |
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Categoria do assunto: |
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L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02235naa a2200301 a 4500
001 1970948
005 2013-11-25
008 2013 bl uuuu u00u1 u #d
024 7 $a10.1089/vim.2013.0015$2DOI
100 1 $aOKINO, C. H.
245 $aHumoral and Cell-Mediated Immune Responses to Different Doses of Attenuated Vaccine Against Avian Infectious Bronchitis Virus.$h[electronic resource]
260 $c2013
520 $aThe antibody and cellular immune responses against infectious bronchitis virus (IBV) were evaluated at mucosal sites of chickens after immunization with various doses of an attenuated vaccine at 1 day of age. The correlation of these immune responses with protection of tracheal tissues was evaluated after experimental infection of these birds. Significantly reduced tracheal pathologic effects, measured according to ciliostasis and histology lesions, and reduced viral load were observed only in the full-dose vaccinated group at 5 days post-infection (dpi), while incomplete protection was observed for the subdose vaccinated groups. Moreover, birds of vaccinated groups, especially with full dose, developed higher levels of lachrymal IBV-specific IgG and IgA and increased the expression of cell-mediated immunity (CMI) genes, such as gamma interferon (IFN gamma), CD8+ T cell marker, and granzyme homolog A more rapidly. In addition, these humoral and cellular immune responses evaluated at mucosal sites correlated significantly with tracheal protection against homologous IBV challenge in a vaccine dose-dependent manner. The results indicate that IgG, IgA and CD8+ T cell responses developed at mucosal sites after IBV vaccination of day-old chicks, could be taken as good correlates of protection against this virus. (AU)
650 $aAviculture
650 $aImmune response
650 $aInfectious Bronchitis
650 $aVaccination
650 $aImunologia
650 $aVacina
650 $aVirologia
650 $aVírus
653 $aBronquite infecciosa aviária
700 1 $aALESSI, A. C.
700 1 $aMONTASSIER, M. de F. S.
700 1 $aROSA, A. J. de M.
700 1 $aWANG, X.
700 1 $aMONTASSIER, H. J.
773 $tViral Immunology, Nova York$gv. 26, n. 4, p. 1-9, 2013.
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Registro original: |
Embrapa Cerrados (CPAC) |
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