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 | Acesso ao texto completo restrito à biblioteca da Embrapa Rondônia. Para informações adicionais entre em contato com cpafro.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Rondônia. |
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Data corrente: |
14/08/2013 |
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Data da última atualização: |
14/08/2013 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
AKBAR, H.; SCHMITT, E.; BALLOU, M. A.; CORRÊA, M. N.; DEPETERS, E. J.; LOOR, J. J. |
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Afiliação: |
haji Akbar, University of illinois, Urbana; EDUARDO SCHMITT, CPAF-RO; Michael A. Ballou, Texas Tech University; Marcio N. Corrêa, NUPeeC, UFPel; Edward J. DePeter, University of California; Juan J. Loor, University of illinois, Urbana. |
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Título: |
Dietary Lipid During Late-pregnancy and early-Lactation to Manipulate Metabolic and Inflammatory Gene Network Expression in Dairy Cattle Liver with a Focus on PPARs. |
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Ano de publicação: |
2013 |
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Fonte/Imprenta: |
Gene Regulation and Systems Biology, v. 7, p. 103?123, 2013. |
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Idioma: |
Inglês |
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Conteúdo: |
Polyunsaturated (PUFA) long-chain fatty acids (LCFAs) are more potent in eliciting molecular and tissue functional changes in monogastrics than saturated LCFA. From −21 through 10 days relative to parturition dairy cows were fed no supplemental LCFA (control), saturated LCFA (SFAT; mainly 16:0 and 18:0), or fish oil (FISH; high-PUFA). Twenty-seven genes were measured via quantitative RT-PCR in liver tissue on day −14 and day 10. Expression of nuclear receptor co-activators (CARM1, MED1), LCFA metabolism (ACSL1, SCD, ACOX1), and inflammation (IL6, TBK1, IKBKE) genes was lower with SFAT than control on day −14. Expression of SCD, however, was markedly lower with FISH than control or SFAT on both −14 and 10 days. FISH led to further decreases in expression on day 10 of LCFA metabolism (CD36, PLIN2, ACSL1, ACOX1), intracellular energy (UCP2, STK11, PRKAA1), de novo cholesterol synthesis (SREBF2), inflammation (IL6, TBK1, IKBKE), and nuclear receptor signaling genes (PPARD, MED1, NRIP1). No change in expression was observed for PPARA and RXRA. The increase of DGAT2, PLIN2, ACSL1, and ACOX1 on day 10 versus −14 in cows fed SFAT suggested upregulation of both beta-oxidation and lipid droplet (LD) formation. However, liver triacylglycerol concentration was similar among treatments. The hepatokine FGF21 and the gluconeogenic genes PC and PCK1 increased markedly on day 10 versus −14 only in controls. At the levels supplemented, the change in the profile of metabolic genes after parturition in cows fed saturated fat suggested a greater capacity for uptake of fatty acids and intracellular handling without excessive storage of LD. MenosPolyunsaturated (PUFA) long-chain fatty acids (LCFAs) are more potent in eliciting molecular and tissue functional changes in monogastrics than saturated LCFA. From −21 through 10 days relative to parturition dairy cows were fed no supplemental LCFA (control), saturated LCFA (SFAT; mainly 16:0 and 18:0), or fish oil (FISH; high-PUFA). Twenty-seven genes were measured via quantitative RT-PCR in liver tissue on day −14 and day 10. Expression of nuclear receptor co-activators (CARM1, MED1), LCFA metabolism (ACSL1, SCD, ACOX1), and inflammation (IL6, TBK1, IKBKE) genes was lower with SFAT than control on day −14. Expression of SCD, however, was markedly lower with FISH than control or SFAT on both −14 and 10 days. FISH led to further decreases in expression on day 10 of LCFA metabolism (CD36, PLIN2, ACSL1, ACOX1), intracellular energy (UCP2, STK11, PRKAA1), de novo cholesterol synthesis (SREBF2), inflammation (IL6, TBK1, IKBKE), and nuclear receptor signaling genes (PPARD, MED1, NRIP1). No change in expression was observed for PPARA and RXRA. The increase of DGAT2, PLIN2, ACSL1, and ACOX1 on day 10 versus −14 in cows fed SFAT suggested upregulation of both beta-oxidation and lipid droplet (LD) formation. However, liver triacylglycerol concentration was similar among treatments. The hepatokine FGF21 and the gluconeogenic genes PC and PCK1 increased markedly on day 10 versus −14 only in controls. At the levels supplemented, the change in the pro... Mostrar Tudo |
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Palavras-Chave: |
Fat supplementation; Hepatic gene network; Rede de gene hepática; Suplementação de gordura; Vacas leiteiras. |
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Thesaurus Nal: |
Dairy cows. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02512naa a2200253 a 4500
001 1964101
005 2013-08-14
008 2013 bl uuuu u00u1 u #d
100 1 $aAKBAR, H.
245 $aDietary Lipid During Late-pregnancy and early-Lactation to Manipulate Metabolic and Inflammatory Gene Network Expression in Dairy Cattle Liver with a Focus on PPARs.$h[electronic resource]
260 $c2013
520 $aPolyunsaturated (PUFA) long-chain fatty acids (LCFAs) are more potent in eliciting molecular and tissue functional changes in monogastrics than saturated LCFA. From −21 through 10 days relative to parturition dairy cows were fed no supplemental LCFA (control), saturated LCFA (SFAT; mainly 16:0 and 18:0), or fish oil (FISH; high-PUFA). Twenty-seven genes were measured via quantitative RT-PCR in liver tissue on day −14 and day 10. Expression of nuclear receptor co-activators (CARM1, MED1), LCFA metabolism (ACSL1, SCD, ACOX1), and inflammation (IL6, TBK1, IKBKE) genes was lower with SFAT than control on day −14. Expression of SCD, however, was markedly lower with FISH than control or SFAT on both −14 and 10 days. FISH led to further decreases in expression on day 10 of LCFA metabolism (CD36, PLIN2, ACSL1, ACOX1), intracellular energy (UCP2, STK11, PRKAA1), de novo cholesterol synthesis (SREBF2), inflammation (IL6, TBK1, IKBKE), and nuclear receptor signaling genes (PPARD, MED1, NRIP1). No change in expression was observed for PPARA and RXRA. The increase of DGAT2, PLIN2, ACSL1, and ACOX1 on day 10 versus −14 in cows fed SFAT suggested upregulation of both beta-oxidation and lipid droplet (LD) formation. However, liver triacylglycerol concentration was similar among treatments. The hepatokine FGF21 and the gluconeogenic genes PC and PCK1 increased markedly on day 10 versus −14 only in controls. At the levels supplemented, the change in the profile of metabolic genes after parturition in cows fed saturated fat suggested a greater capacity for uptake of fatty acids and intracellular handling without excessive storage of LD.
650 $aDairy cows
653 $aFat supplementation
653 $aHepatic gene network
653 $aRede de gene hepática
653 $aSuplementação de gordura
653 $aVacas leiteiras
700 1 $aSCHMITT, E.
700 1 $aBALLOU, M. A.
700 1 $aCORRÊA, M. N.
700 1 $aDEPETERS, E. J.
700 1 $aLOOR, J. J.
773 $tGene Regulation and Systems Biology$gv. 7, p. 103?123, 2013.
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Registro original: |
Embrapa Rondônia (CPAF-RO) |
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| Registros recuperados : 6 | |
| 1. |  | SILVA, M. S. L. da; CARDOSO, L. B.; FERREIRA, G. B.; CUNHA, T. J. F.; PARAHYBA, R. da B. V. Monitoramento do solo, manejo e produtividade de barragens subterrâneas do estado de Pernambuco. In: REUNIÃO BRASILEIRA DE FERTILIDADE DO SOLO E NUTRIÇÃO DE PLANTAS, 30.; REUNIÃO BRASILEIRA SOBRE MICORRIZAS, 14.; SIMPÓSIO BRASILEIRO DE MICROBIOLOGIA DO SOLO, 12.; REUNIÃO BRASILEIRA DE BIOLOGIA DO SOLO, 9.; SIMPÓSIO SOBRE SELÊNIO NO BRASIL, 1., 2012, Maceió. A responsabilidade socioambiental da pesquisa agrícola: anais. Viçosa, MG: SBCS, 2012. 1 CD-ROM. Fertbio 2012.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Semiárido; Embrapa Solos. |
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| 2. | | BARROS, A. H. C.; ARAUJO FILHO, J. C. de; ALVES, E. da S.; CARDOSO, L. B.; SILVA, N. R. de F. e; SILVA, M. A. da. Mapeamento da fertilidade utilizando levantamentos de reconhecimento de média intensidade de solos no estado de Alagoas. In: REUNIÃO BRASILEIRA DE FERTILIDADE DO SOLO E NUTRIÇÃO DE PLANTAS, 30.; REUNIÃO BRASILEIRA SOBRE MICORRIZAS, 14.; SIMPÓSIO BRASILEIRO DE MICROBIOLOGIA DO SOLO, 12.; REUNIÃO BRASILEIRA DE BIOLOGIA DO SOLO, 9.; SIMPÓSIO SOBRE SELÊNIO NO BRASIL, 1., 2012, Maceió. A responsabilidade socioambiental da pesquisa agrícola: anais. Viçosa, MG: SBCS, 2012. 1 CD-ROM. Fertbio 2012.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Solos; Embrapa Solos / UEP-Recife. |
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| 3. | | CARDOSO, L. B.; SILVA, M. S. L. da; MOTA, C. L.; SILVA, L. S.; PARAHYBA, R. da B. V.; FERREIRA, G. B.; OLIVEIRA NETO, M. B. de; CUNHA, T. J. F. Atributos químicos de solos da área de plantio de barragens subterrâneas do Semiárido da Bahia. In: CONGRESSO BRASILEIRO DE CIÊNCIA DO SOLO, 33., 2011, Uberlândia. Solos nos biomas brasileiros: sustentabilidade e mudanças climáticas: anais. [Uberlândia]: SBCS: UFU, ICIAG, 2011. 1 CD-ROM. 4 p.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Semiárido; Embrapa Solos. |
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| 4. | | SILVA, L. S.; SILVA, M. S. L. da; MOTA, C. L.; CARDOSO, L. B.; FERREIRA, G. B.; PARAHYBA, R. da B. V.; CUNHA, T. J. F.; OLIVEIRA NETO, M. B. de. Atributos físicos de solos da área de plantio de barragens subterrâneas do Semiárido da Bahia. In: CONGRESSO BRASILEIRO DE CIÊNCIA DO SOLO, 33., 2011, Uberlândia. Solos nos biomas brasileiros: sustentabilidade e mudanças climáticas: anais. [Uberlândia]: SBCS: UFU, ICIAG, 2011. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Semiárido; Embrapa Solos. |
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| 6. | | AMARAL, A. J. do; SILVA, A. B. da; ARAUJO FILHO, J. C. de; ACCIOLY, L. J. de O.; SANTOS, J. C. P. dos; OLIVEIRA NETO, M. B. de; GOMES, E. C.; CARDOSO, L. B. Parâmetros químicos em diferentes solos na região dos tabuleiros costeiros no município de Coruripe - AL. In: REUNIÃO BRASILEIRA DE FERTILIDADE DO SOLO E NUTRIÇÃO DE PLANTAS, 30.; REUNIÃO BRASILEIRA SOBRE MICORRIZAS, 14.; SIMPÓSIO BRASILEIRO DE MICROBIOLOGIA DO SOLO, 12.; REUNIÃO BRASILEIRA DE BIOLOGIA DO SOLO, 9.; SIMPÓSIO SOBRE SELÊNIO NO BRASIL, 1., 2012, Maceió. A responsabilidade socioambiental da pesquisa agrícola: anais. Viçosa, MG: SBCS, 2012. 1 CD-ROM. Fertbio 2012.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Solos. |
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| Registros recuperados : 6 | |
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