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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
08/12/2011 |
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Data da última atualização: |
05/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
LEITE, J. de A.; FONSECA, F. G. da; TRINDADE, G. de S.; ABRAHÃO, J. S.; ARANTES, R. M. E.; ALMEIDA-LEITE, C. M. de; SANTOS, J. R. dos; GUEDES, M. I. M. C.; RIBEIRO, B. M.; BONJARDIM, C. A.; FERREIRA, P. C. P.; KROON, E. G. |
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Afiliação: |
JULIANA DE ALMEIDA LEITE, CNPGL; FLÁVIO GUIMARÃES DA FONSECA, FIOCRUZ; GILIANE DE SOUZA TRINDADE, UFMG; JÔNATAS SANTOS ABRAHÃO; ROSA MARIA ESTEVES ARANTES, UFMG; CAMILA MEGALE DE ALMEIDA-LEITE, UFMG; JOÃO RODRIGUES DOS SANTOS, UFMG; MARIA ISABEL MALDONADO COELHO GUEDES; BERGMANN MORAIS RIBEIRO, UNB; CLÁUDIO ANTÔNIO BONJARDIM, UFMG; PAULO CÉSAR PEREGRINO FERREIRA, UFMG; ERNA GEESSIEN KROON, UFMG. |
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Título: |
A-type inclusion bodies: a factor influencing cowpox virus lesion pathogenesis. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Archives of Virology, n. 156, n. 4, p. 617-628, 2011. |
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DOI: |
https://doi.org/10.1007/s00705-010-0900-0 |
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Idioma: |
Inglês |
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Conteúdo: |
The family Poxviridae comprises the most complex animal DNA viruses. During some poxvirus infections, A-type inclusion bodies (ATIs), codified by the ati gene, are produced. Although some studies have compared poxviruses that encode these inclusion bodies with those that do not, the biological function of ATIs is poorly understood. A recombinant ati-deleted cowpox virus was constructed and compared with the wild-type virus in in vitro experiments including electron microscopy and plaque and viral growth assays. No significant differences were observed in vitro. This reinforces the conclusion that the inclusion body is not essential for in vitro viral replication and morphogenesis. Additionally, different lesion progressions in vivo were observed by macroscopic and histological analysis, suggesting that the presence or absence of ATIs could result in different healing dynamics. This is the first time that the role of ATIs during viral replication has been studied based solely on one variable, the presence or absence of ATIs. |
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Palavras-Chave: |
ATI's. |
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Thesaurus Nal: |
Poxviridae. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 01905naa a2200289 a 4500
001 1909138
005 2024-02-05
008 2011 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s00705-010-0900-0$2DOI
100 1 $aLEITE, J. de A.
245 $aA-type inclusion bodies$ba factor influencing cowpox virus lesion pathogenesis.$h[electronic resource]
260 $c2011
520 $aThe family Poxviridae comprises the most complex animal DNA viruses. During some poxvirus infections, A-type inclusion bodies (ATIs), codified by the ati gene, are produced. Although some studies have compared poxviruses that encode these inclusion bodies with those that do not, the biological function of ATIs is poorly understood. A recombinant ati-deleted cowpox virus was constructed and compared with the wild-type virus in in vitro experiments including electron microscopy and plaque and viral growth assays. No significant differences were observed in vitro. This reinforces the conclusion that the inclusion body is not essential for in vitro viral replication and morphogenesis. Additionally, different lesion progressions in vivo were observed by macroscopic and histological analysis, suggesting that the presence or absence of ATIs could result in different healing dynamics. This is the first time that the role of ATIs during viral replication has been studied based solely on one variable, the presence or absence of ATIs.
650 $aPoxviridae
653 $aATI's
700 1 $aFONSECA, F. G. da
700 1 $aTRINDADE, G. de S.
700 1 $aABRAHÃO, J. S.
700 1 $aARANTES, R. M. E.
700 1 $aALMEIDA-LEITE, C. M. de
700 1 $aSANTOS, J. R. dos
700 1 $aGUEDES, M. I. M. C.
700 1 $aRIBEIRO, B. M.
700 1 $aBONJARDIM, C. A.
700 1 $aFERREIRA, P. C. P.
700 1 $aKROON, E. G.
773 $tArchives of Virology$gn. 156, n. 4, p. 617-628, 2011.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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Registro |
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Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
23/06/2022 |
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Data da última atualização: |
23/06/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
DUARTE, I. N. H.; BESSA, A. F. DE O.; ROLA, L. D.; GENUÍNO, M. V. H.; ROCHA, I. M.; MARCONDES, C. R.; REGITANO, L. C. de A.; MUNARI, D. P.; BERRY, D. P.; BUZANSKAS, M. E. |
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Afiliação: |
IGOR NELSON HERCULANO DUARTE, UNIVERSIDADE FEDERAL DA PARAÍBA; AYRTON FERNANDES DE OLIVEIRA BESSA, UNIVERSIDADE FEDERAL DA PARAÍBA; LUCIANA DINIZ ROLA, UNIVERSIDADE FEDERAL DA PARAÍBA; MARIA VICTORIA HENRIQUE GENUÍNO, UNIVERSIDADE FEDERAL DA PARAÍBA; IASMIM MARQUES ROCHA, UNIVERSIDADE FEDERAL DA PARAÍBA; CINTIA RIGHETTI MARCONDES, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; DANISIO PRADO MUNARI, UNESP; DONAGH PEARSE BERRY, TEAGASC, Anim & Grassland Res & Innovat Ctr, Moorepark, Cork, Ireland; MARCOS ELI BUZANSKAS, UNIVERSIDADE FEDERAL DA PARAÍBA. |
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Título: |
Cross-population selection signatures in Canchim composite beef cattle. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Plos One, v.17, n.4, 2022, e0264279. |
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Páginas: |
15 p. |
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ISSN: |
1932-6203 |
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DOI: |
10.1371/journal.pone.0264279 |
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Idioma: |
Inglês |
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Conteúdo: |
Analyses of livestock genomes have been used to detect selection signatures, which are genomic regions associated with traits under selection leading to a change in allele frequency. The objective of the present study was to characterize selection signatures in Canchim composite beef cattle using cross-population analyses with the founder Nelore and Charolais breeds. High-density single nucleotide polymorphism genotypes were available on 395 Canchim representing the target population, along with genotypes from 809 Nelore and 897 Charolais animals representing the reference populations. Most of the selection signatures were co-located with genes whose functions agree with the expectations of the breeding programs; these genes have previously been reported to associate with meat quality, as well as reproductive traits. Identified genes were related to immunity, adaptation, morphology, as well as behavior, could give new perspectives for understanding the genetic architecture of Canchim. Some selection signatures identified genes that were recently introduced in Canchim, such as the loci related to the polled trait. |
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Palavras-Chave: |
Genome Wide Association; Identification; Positive selection; Scan; Target gene; Traits. |
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Thesaurus NAL: |
Animal stress; Polymorphism. |
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Categoria do assunto: |
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1144244/1/CrossPopulationSelection.pdf
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Marc: |
LEADER 02112naa a2200361 a 4500
001 2144244
005 2022-06-23
008 2022 bl uuuu u00u1 u #d
022 $a1932-6203
024 7 $a10.1371/journal.pone.0264279$2DOI
100 1 $aDUARTE, I. N. H.
245 $aCross-population selection signatures in Canchim composite beef cattle.$h[electronic resource]
260 $c2022
300 $a15 p.
520 $aAnalyses of livestock genomes have been used to detect selection signatures, which are genomic regions associated with traits under selection leading to a change in allele frequency. The objective of the present study was to characterize selection signatures in Canchim composite beef cattle using cross-population analyses with the founder Nelore and Charolais breeds. High-density single nucleotide polymorphism genotypes were available on 395 Canchim representing the target population, along with genotypes from 809 Nelore and 897 Charolais animals representing the reference populations. Most of the selection signatures were co-located with genes whose functions agree with the expectations of the breeding programs; these genes have previously been reported to associate with meat quality, as well as reproductive traits. Identified genes were related to immunity, adaptation, morphology, as well as behavior, could give new perspectives for understanding the genetic architecture of Canchim. Some selection signatures identified genes that were recently introduced in Canchim, such as the loci related to the polled trait.
650 $aAnimal stress
650 $aPolymorphism
653 $aGenome Wide Association
653 $aIdentification
653 $aPositive selection
653 $aScan
653 $aTarget gene
653 $aTraits
700 1 $aBESSA, A. F. DE O.
700 1 $aROLA, L. D.
700 1 $aGENUÍNO, M. V. H.
700 1 $aROCHA, I. M.
700 1 $aMARCONDES, C. R.
700 1 $aREGITANO, L. C. de A.
700 1 $aMUNARI, D. P.
700 1 $aBERRY, D. P.
700 1 $aBUZANSKAS, M. E.
773 $tPlos One$gv.17, n.4, 2022, e0264279.
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Embrapa Pecuária Sudeste (CPPSE) |
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