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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Ocidental. |
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Data corrente: |
19/09/2006 |
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Data da última atualização: |
06/01/2015 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
FUKUMASU, H.; AVANZO, J. L.; HEIDOR, R.; SILVA, T. C.; ATROCH, A.; MORENO, F. S.; DAGLI, M. L. Z. |
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Afiliação: |
H. Fukumasu, USP; J.L. Avanzo, USP; R. Heidor, USP; T.C. Silva, USP; André Atroch, CPAA; F.S. Moreno, USP; M.L.Z. Dagli, USP. |
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Título: |
Protective effects of guarana (Paullinia cupana Mart. var. Sorbilis) against DEN-induced DNA damage on mouse liver. |
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Ano de publicação: |
2006 |
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Fonte/Imprenta: |
Food and Chemical Toxicology, v. 44, n. 6 , p. 862-867, jun. 2006. |
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Idioma: |
Inglês |
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Conteúdo: |
Guarana (Paullinia cupana Mart. var. Sorbilis) is a plant originally from Brazil, which is rich in tannins. Some tannins are known to present protective effects against DNA damage. This study was performed to investigate the anti-genotoxic/cytotoxic properties of guarana in hepatocytes of mice injected with N-nitrosodiethylamine (DEN). The protective effect of guarana was evaluated both by comet assay and DNA smear fragmentation technique in two month-old female BALB/c mice. These were treated previously with 2.0 mg/g bw of guarana for 16 days and then injected with DEN (160 µg/g body weight) to induce DNA damage. The DEN-only treated group presented higher comet image length than the guarana plus DEN and untreated groups (116.06 ± 5.0 µm, 104.09 ± 3.3 µm and 93.28 ± 14.4 µm, respectively; p < 0.01). Guarana treatment presented a 52.54% reduction in comet image length when animals were exposed to DEN (p < 0.05). DNA samples from the guarana plus DEN group clearly showed less EtBr fluorescence intensity when compared to the DEN-only group, reinforcing the comet assay data. These results show, for the first time, that guarana has a protective effect against DEN-induced DNA damage in mouse liver. |
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Thesagro: |
DNA; Guaraná; Paullinia Cupana. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01880naa a2200229 a 4500
001 1678895
005 2015-01-06
008 2006 bl uuuu u00u1 u #d
100 1 $aFUKUMASU, H.
245 $aProtective effects of guarana (Paullinia cupana Mart. var. Sorbilis) against DEN-induced DNA damage on mouse liver.
260 $c2006
520 $aGuarana (Paullinia cupana Mart. var. Sorbilis) is a plant originally from Brazil, which is rich in tannins. Some tannins are known to present protective effects against DNA damage. This study was performed to investigate the anti-genotoxic/cytotoxic properties of guarana in hepatocytes of mice injected with N-nitrosodiethylamine (DEN). The protective effect of guarana was evaluated both by comet assay and DNA smear fragmentation technique in two month-old female BALB/c mice. These were treated previously with 2.0 mg/g bw of guarana for 16 days and then injected with DEN (160 µg/g body weight) to induce DNA damage. The DEN-only treated group presented higher comet image length than the guarana plus DEN and untreated groups (116.06 ± 5.0 µm, 104.09 ± 3.3 µm and 93.28 ± 14.4 µm, respectively; p < 0.01). Guarana treatment presented a 52.54% reduction in comet image length when animals were exposed to DEN (p < 0.05). DNA samples from the guarana plus DEN group clearly showed less EtBr fluorescence intensity when compared to the DEN-only group, reinforcing the comet assay data. These results show, for the first time, that guarana has a protective effect against DEN-induced DNA damage in mouse liver.
650 $aDNA
650 $aGuaraná
650 $aPaullinia Cupana
700 1 $aAVANZO, J. L.
700 1 $aHEIDOR, R.
700 1 $aSILVA, T. C.
700 1 $aATROCH, A.
700 1 $aMORENO, F. S.
700 1 $aDAGLI, M. L. Z.
773 $tFood and Chemical Toxicology$gv. 44, n. 6 , p. 862-867, jun. 2006.
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Registro original: |
Embrapa Amazônia Ocidental (CPAA) |
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Registro Completo
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Biblioteca(s): |
Embrapa Hortaliças. |
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Data corrente: |
28/02/1996 |
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Data da última atualização: |
24/11/2009 |
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Autoria: |
SPINA, J. B.; PARMAGNANI, R. M.; PARENTE, M. R. org. |
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Afiliação: |
EMBRAPA-CNPH, Brasilia, DF. |
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Título: |
Bibliografia brasileira de tomate. |
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Ano de publicação: |
1995 |
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Fonte/Imprenta: |
Brasilia: EMBRAPA-CNPH, 1995-1998. |
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Volume: |
3v. |
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Série: |
(EMBRAPA-CNPH. Documentos, 15). |
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Idioma: |
Português |
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Palavras-Chave: |
Bibliografia; Bibliography; Brasil; Tomato. |
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Thesagro: |
Lycopersicon Esculentum; Tomate. |
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Thesaurus NAL: |
Brazil. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 00592nam a2200229 a 4500
001 1754446
005 2009-11-24
008 1995 bl uuuu de 00u1 u #d
100 1 $aSPINA, J. B.
245 $aBibliografia brasileira de tomate.
260 $aBrasilia: EMBRAPA-CNPH, 1995-1998.$c1998
300 $a3v.
490 $a(EMBRAPA-CNPH. Documentos, 15).$v3v.
650 $aBrazil
650 $aLycopersicon Esculentum
650 $aTomate
653 $aBibliografia
653 $aBibliography
653 $aBrasil
653 $aTomato
700 1 $aPARMAGNANI, R. M.
700 1 $aPARENTE, M. R. org.
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